Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 575567..576045 Replicon chromosome
Accession NZ_CP044143
Organism Escherichia coli O157 strain AR-0429

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A891SFN9
Locus tag F4V41_RS04495 Protein ID WP_001303876.1
Coordinates 575758..576045 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XD67
Locus tag F4V41_RS04490 Protein ID WP_000536233.1
Coordinates 575567..575758 (+) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F4V41_RS04455 570971..571741 - 771 WP_000450992.1 DUF1627 domain-containing protein -
F4V41_RS04460 571763..572509 - 747 WP_000788751.1 ATP-binding protein -
F4V41_RS04465 572516..573607 - 1092 WP_001205823.1 hypothetical protein -
F4V41_RS04470 573686..574141 + 456 WP_000273724.1 hypothetical protein -
F4V41_RS04475 574348..574773 - 426 WP_000693855.1 Rha family transcriptional regulator -
F4V41_RS04480 574757..575029 - 273 WP_000887453.1 helix-turn-helix domain-containing protein -
F4V41_RS04485 575138..575539 + 402 WP_000986592.1 helix-turn-helix domain-containing protein -
F4V41_RS04490 575567..575758 + 192 WP_000536233.1 hypothetical protein Antitoxin
F4V41_RS04495 575758..576045 + 288 WP_001303876.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
F4V41_RS04505 576323..576478 + 156 WP_000379575.1 DUF1391 family protein -
F4V41_RS04510 576620..577009 + 390 WP_000394511.1 hypothetical protein -
F4V41_RS04515 577196..577381 - 186 WP_001133046.1 hypothetical protein -
F4V41_RS04525 577955..578143 + 189 WP_000413705.1 cell division inhibition protein DicB -
F4V41_RS04530 578140..578331 + 192 WP_001098307.1 DUF1482 family protein -
F4V41_RS04535 578425..580896 + 2472 WP_000034474.1 exonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10978.84 Da        Isoelectric Point: 10.1360

>T140206 WP_001303876.1 NZ_CP044143:575758-576045 [Escherichia coli O157]
MLPILWLPSARDDLRQIITYIAKENPPAARRLKIRIETSVLPLSEHPYLYPPSERVSGLREIVTHPNYIILYRVAASSIE
IVSVTHSRRQFPFSI

Download         Length: 288 bp

>T140206 NZ_CP059043:183643-183750 [Escherichia coli]
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7025.80 Da        Isoelectric Point: 4.0270

>AT140206 WP_000536233.1 NZ_CP044143:575567-575758 [Escherichia coli O157]
MGTALSPIVSEFETTEQENSYNEWLRTKVTSSLADTRPAIPHDEVMAEMENLIAQIAVTNKSE

Download         Length: 192 bp

>AT140206 NZ_CP059043:c183594-183528 [Escherichia coli]
GTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References