Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 45362..45840 Replicon chromosome
Accession NZ_CP044140
Organism Escherichia coli O157 strain AR-0430

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A891SFN9
Locus tag F4V42_RS01760 Protein ID WP_001303876.1
Coordinates 45553..45840 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XD67
Locus tag F4V42_RS01755 Protein ID WP_000536233.1
Coordinates 45362..45553 (+) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F4V42_RS01720 40766..41536 - 771 WP_000450992.1 DUF1627 domain-containing protein -
F4V42_RS01725 41558..42304 - 747 WP_000788751.1 ATP-binding protein -
F4V42_RS01730 42311..43402 - 1092 WP_001205823.1 hypothetical protein -
F4V42_RS01735 43481..43936 + 456 WP_000273724.1 hypothetical protein -
F4V42_RS01740 44143..44568 - 426 WP_000693855.1 Rha family transcriptional regulator -
F4V42_RS01745 44552..44824 - 273 WP_000887453.1 helix-turn-helix domain-containing protein -
F4V42_RS01750 44933..45334 + 402 WP_000986592.1 helix-turn-helix domain-containing protein -
F4V42_RS01755 45362..45553 + 192 WP_000536233.1 hypothetical protein Antitoxin
F4V42_RS01760 45553..45840 + 288 WP_001303876.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
F4V42_RS01765 46119..46274 + 156 WP_000379575.1 DUF1391 family protein -
F4V42_RS01770 46416..46805 + 390 WP_000394511.1 hypothetical protein -
F4V42_RS01775 46992..47177 - 186 WP_001133046.1 hypothetical protein -
F4V42_RS01785 47751..47939 + 189 WP_000413705.1 cell division inhibition protein DicB -
F4V42_RS01790 47936..48127 + 192 WP_001098307.1 DUF1482 family protein -
F4V42_RS01795 48221..50692 + 2472 WP_000034474.1 exonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10978.84 Da        Isoelectric Point: 10.1360

>T140172 WP_001303876.1 NZ_CP044140:45553-45840 [Escherichia coli O157]
MLPILWLPSARDDLRQIITYIAKENPPAARRLKIRIETSVLPLSEHPYLYPPSERVSGLREIVTHPNYIILYRVAASSIE
IVSVTHSRRQFPFSI

Download         Length: 288 bp

>T140172 NZ_CP059003:934043-934411 [Escherichia coli]
ATGAAAACTCTACCTGCAACGACTCCGCAGGCGGCGAAGCCCTGTCTGTCGCCCGTGTCTGTCTGGCAAATGTTACTTAC
TCGTCTACTTGAGCAGCACTATGGCCTAATGTTAAGCGACACACCTTTTAGCGATGAAACAGTTATAAAGGAGCATATCG
ATGCCGGTATCACTCTGGCTAATGCCGTTAACTTTCTTGTAGAGAAATATGAGTTAGTTCGTATCGATCGCAATGGATTT
ACCTCTCAGGTACAAGCACCATATTTGACTACGACAGACATTCTTCAAGCTAGGAAAGCGTGCGGGCTGATGAGCCGGTG
TTCTTACAGGGAGGTAAGTAATATTGTTCTTAGCCGATCACGGCTGTGA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7025.80 Da        Isoelectric Point: 4.0270

>AT140172 WP_000536233.1 NZ_CP044140:45362-45553 [Escherichia coli O157]
MGTALSPIVSEFETTEQENSYNEWLRTKVTSSLADTRPAIPHDEVMAEMENLIAQIAVTNKSE

Download         Length: 192 bp

>AT140172 NZ_CP059003:933705-934022 [Escherichia coli]
ATGAGTAACATCACATGGGGCCTGCAGCGGGATATCACACCGCGCCTGGGAGCACGTCTGGTGCAGGAGGGCAACCAACT
GCATTATTTGGCTGACCGGGCCAGTATCACCGGTAAATTCAGTGACGCCGAATACCGGAAGCTGGATGAAACATTCCCGC
ACTTTATCAGCCAGATGGAATCGATGCTTACCACTGGTGAAATGAATCCTCGCCACGCCCACTGCGTCACCCTGTACCAC
GATGGTTTCACCTGCGAAGCCGATACCCTTGGCAGTTGCGGCTACGTATACATCGTCGTCTACTCCACTCAACGCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References