Detailed information of TA system TA140162

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-MqsA
• Location: 3793863..3794562
• Replicon: chromosome
• Accession: NZ_CP044136
• Organism: Proteus mirabilis strain ENT1157

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: F4W58_RS17595
• Protein ID: WP_017628658.1
• Coordinates: 3793863..3794249 (+)
• Length: 129 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: B4EZ97
• Locus tag: F4W58_RS17600
• Protein ID: WP_004246828.1
• Coordinates: 3794242..3794562 (+)
• Length: 107 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
F4W58_RS17580	3789882..3790463	-	582	WP_012368524.1	DNA-3-methyladenine glycosylase I	-
F4W58_RS17585	3790714..3791619	+	906	WP_004246832.1	glycine--tRNA ligase subunit alpha	-
F4W58_RS17590	3791629..3793701	+	2073	WP_017628659.1	glycine--tRNA ligase subunit beta	-
F4W58_RS17595	3793863..3794249	+	387	WP_017628658.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
F4W58_RS17600	3794242..3794562	+	321	WP_004246828.1	helix-turn-helix domain-containing protein	Antitoxin
F4W58_RS17605	3794611..3795045	-	435	WP_004246827.1	hypothetical protein	-
F4W58_RS17610	3795038..3795922	-	885	WP_012368526.1	endonuclease/exonuclease/phosphatase family protein	-
F4W58_RS17615	3796137..3797423	-	1287	WP_017628657.1	DUF3748 domain-containing protein	-
F4W58_RS17620	3797560..3798177	+	618	WP_004246822.1	trimeric intracellular cation channel family protein	-
F4W58_RS17625	3798478..3799101	+	624	WP_004246821.1	guanylate kinase	-
F4W58_RS17630	3799156..3799431	+	276	WP_004246820.1	DNA-directed RNA polymerase subunit omega	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-2 (1-125)

Antitoxin

• Cro/C1-type helix-turn-helix domain (53-95)

Sequences

Toxin

Protein

• Length: 129 a.a.
• Molecular weight: 14322.65 Da
• Isoelectric Point: 10.0826

>T140162 WP_017628658.1 NZ_CP044136:3793863-3794249 [Proteus mirabilis]
MVIYKTKMFKNSFKKITLTNAELIAIATEVLAGQFEADLGGGVIKKRACIQGKGKSSGIRTIIFYKQGNNLFFADGWKKS
SLSSKKTKEITDDELESYKDLAKDLFNANQNKIDKMIALGLLTEVRYD

Nucleotide

• Length: 387 bp

>T140162 NZ_CP058993:c856750-856457 [Pasteurella multocida]
ATGAGTAAGAAAAAAATAAAATTAAAACTGTTTGATATTGCTGAACATCTAGACAGTGAAGAAATGATTGCGGCATATTT
AAGTGAAGTTTTAGAAACATGTGATACTAATGAATTTATTTCCGCTTTAGCTGATGTTGTAAGAGCAAAAGGAATGACGG
AGTTAGCAGCAAAAACAGGGTTAAGAAGAGAAAGCCTCTATAAAACATTATCATACGGTAGCAAGCCACGTTTTGATACG
ATAATGAAAATTACGCATTCATTAGGTATTAAACTTGTCCCAACGCACATCTAA

Antitoxin

Protein

• Length: 107 a.a.
• Molecular weight: 12126.21 Da
• Isoelectric Point: 10.4411

>AT140162 WP_004246828.1 NZ_CP044136:3794242-3794562 [Proteus mirabilis]
MTDKMKEMLKFAQEMEDAGVTDGSTTKRIAARIKAKELQAKYKHPTPMTGEDIKRIREQNNISQSSLALILNMTKESVSK
WERNEIKPNGAALRLLHLIDKKILFI

Nucleotide

• Length: 321 bp

>AT140162 NZ_CP058993:c857031-856747 [Pasteurella multocida]
GTGGGTCGGTTAAGGGAGGTAAAAAATTTATCCGCCAAAGCCGCTGTTCTTGCTCGTATTAACAGAGTAATGAATGGTAA
TTTGGGCGATCATAAATCGATTGGAAATGGATTGTATGAGATGAGAATTATAAAAGGTTCGGGTTATAGAGTTTACTATG
GACAATATAGAGAAGTAACTTATTTATTAATTTGTGGTGGCGATAAATCAACACAGAAATCAGACATTGTTAAAGCGAGA
GAGTTGTGGAAAGAAATAAAGCAACAAGAGGAAGTAAAAGTATGA

Structures

Antitoxin

• AlphaFold DB: B4EZ97