Detailed information of TA system TA140160

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tacAT/DUF1778(antitoxin)
• Location: 1808034..1808833
• Replicon: chromosome
• Accession: NZ_CP044136
• Organism: Proteus mirabilis strain ENT1157

Toxin (Protein)

• Gene name: TacT3
• Uniprot ID: A0A8E3RD10
• Locus tag: F4W58_RS08635
• Protein ID: WP_004247966.1
• Coordinates: 1808309..1808833 (+)
• Length: 175 a.a.

Antitoxin (Protein)

• Gene name: TacA3
• Uniprot ID: B4EVS2
• Locus tag: F4W58_RS08630
• Protein ID: WP_004247964.1
• Coordinates: 1808034..1808312 (+)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
F4W58_RS08605	1803384..1804466	+	1083	WP_004242680.1	peptide chain release factor 1	-
F4W58_RS08610	1804466..1805314	+	849	WP_004247962.1	peptide chain release factor N(5)-glutamine methyltransferase	-
F4W58_RS08615	1805292..1806107	+	816	WP_004242688.1	invasion regulator SirB1	-
F4W58_RS08620	1806165..1807019	+	855	WP_004242689.1	3-deoxy-8-phosphooctulonate synthase	-
F4W58_RS08625	1807027..1807956	+	930	WP_017628160.1	TIGR01212 family radical SAM protein	-
F4W58_RS08630	1808034..1808312	+	279	WP_004247964.1	DUF1778 domain-containing protein	Antitoxin
F4W58_RS08635	1808309..1808833	+	525	WP_004247966.1	hypothetical protein	Toxin
F4W58_RS08640	1808914..1810614	-	1701	WP_017628159.1	C4-dicarboxylic acid transporter DauA	-
F4W58_RS08650	1811578..1812519	+	942	WP_004242695.1	glyoxylate/hydroxypyruvate reductase GhrA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Vibrio phage ICP1, Orf50 (5-87)

Sequences

Toxin

Protein

• Length: 175 a.a.
• Molecular weight: 19192.12 Da
• Isoelectric Point: 9.3561

>T140160 WP_004247966.1 NZ_CP044136:1808309-1808833 [Proteus mirabilis]
MTIPNWHEEAISKKHNRNGFNCGDAVLNQFLYRHARQNHENGSAKTYLAINNSNNIILGYYSLCPASIEFERTPELIKHG
LARHDIPVFKLARLATDLSVQGKGLGGQLLLAAGRRCLSVASELGGVALLIDAKNERVANWYISYGAIPLLDTPLSLLIS
FKTIYTALSMANKI

Nucleotide

• Length: 525 bp

>T140160 NZ_CP058992:c856751-856458 [Pasteurella multocida]
ATGAGTAAGAAAAAAATAAAATTAAAACTGTTTGATATTGCTGAACATCTAGACAGTGAAGAAATGATTGCGGCATATTT
AAGTGAAGTTTTAGAAACATGTGATACTAATGAATTTATTTCCGCTTTAGCTGATGTTGTAAGAGCAAAAGGAATGACGG
AGTTAGCAGCAAAAACAGGGTTAAGAAGAGAAAGCCTCTATAAAACATTATCATACGGTAGCAAGCCACGTTTTGATACG
ATAATGAAAATTACGCATTCATTAGGTATTAAACTTGTCCCAACGCACATCTAA

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10252.82 Da
• Isoelectric Point: 5.1369

>AT140160 WP_004247964.1 NZ_CP044136:1808034-1808312 [Proteus mirabilis]
MAQALVENSERVSIRITTEDKSLLVRAASLENTNLTEFVLRNIVPVARQVIENNERLKLSEKDTLRVMELLDNPPKPNAK
LLAAAFALPDNA

Nucleotide

• Length: 279 bp

>AT140160 NZ_CP058992:c857032-856748 [Pasteurella multocida]
GTGGGTCGGTTAAGGGAGGTAAAAAATTTATCCGCCAAAGCCGCTGTTCTTGCTCGTATTAACAGAGTAATGAATGGTAA
TTTGGGCGATCATAAATCGATTGGAAATGGATTGTATGAGATGAGAATTATAAAAGGTTCGGGTTATAGAGTTTACTATG
GACAATATAGAGAAGTAACTTATTTATTAATTTGTGGTGGCGATAAATCAACACAGAAATCAGACATTGTTAAAGCGAGA
GAGTTGTGGAAAGAAATAAAGCAACAAGAGGAAGTAAAAGTATGA

Structures

Antitoxin

• AlphaFold DB: B4EVS2