Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 19059..19660 Replicon chromosome
Accession NZ_CP044136
Organism Proteus mirabilis strain ENT1157

Toxin (Protein)


Gene name doc Uniprot ID A0A2X2BIG8
Locus tag F4W58_RS00090 Protein ID WP_004246497.1
Coordinates 19059..19442 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A1Z1SPN9
Locus tag F4W58_RS00095 Protein ID WP_004246496.1
Coordinates 19439..19660 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F4W58_RS00065 14430..14888 + 459 WP_017628716.1 GNAT family N-acetyltransferase -
F4W58_RS00070 14984..15721 - 738 WP_004249950.1 sel1 repeat family protein -
F4W58_RS00075 15830..16729 + 900 WP_017628715.1 N-acetylmuramic acid 6-phosphate etherase -
F4W58_RS00080 17086..18324 - 1239 WP_017628714.1 HipA domain-containing protein -
F4W58_RS00085 18337..18651 - 315 WP_004246498.1 helix-turn-helix domain-containing protein -
F4W58_RS00090 19059..19442 - 384 WP_004246497.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
F4W58_RS00095 19439..19660 - 222 WP_004246496.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
F4W58_RS00100 19905..20768 - 864 WP_004249947.1 YicC family protein -
F4W58_RS00105 20895..21611 + 717 WP_004249760.1 ribonuclease PH -
F4W58_RS00110 21693..22337 + 645 WP_017628713.1 orotate phosphoribosyltransferase -
F4W58_RS00115 22656..23261 - 606 WP_004246491.1 nucleoid occlusion factor SlmA -
F4W58_RS00120 23381..23839 - 459 WP_004246490.1 dUTP diphosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(5-115)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-52)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14471.53 Da        Isoelectric Point: 8.5125

>T140158 WP_004246497.1 NZ_CP044136:c19442-19059 [Proteus mirabilis]
MIWVSAQEVIAFHDRILQRFPGVAGMSDPGRAEALIYRVQNRKHYEGITDVFELAATYWVAIARGHIFNDGNKRTAFFVT
MTFLYRNGIRIRDTGNMLENLTVEAATGEKTVDQLAKHLQNLVEKTN

Download         Length: 384 bp

>T140158 NZ_CP058991:c856751-856458 [Pasteurella multocida]
ATGAGTAAGAAAAAAATAAAATTAAAACTGTTTGATATTGCTGAACATCTAGACAGTGAAGAAATGATTGCGGCATATTT
AAGTGAAGTTTTAGAAACATGTGATACTAATGAATTTATTTCCGCTTTAGCTGATGTTGTAAGAGCAAAAGGAATGACGG
AGTTAGCAGCAAAAACAGGGTTAAGAAGAGAAAGCCTCTATAAAACATTATCATACGGTAGCAAGCCACGTTTTGATACG
ATAATGAAAATTACGCATTCATTAGGTATTAAACTTGTCCCAACGCACATCTAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8260.23 Da        Isoelectric Point: 5.5667

>AT140158 WP_004246496.1 NZ_CP044136:c19660-19439 [Proteus mirabilis]
MRTYTSTQARANISEVLDIATHGEPVEITRRDGCSAVVISKTEFESYQNAKLDAEFDMMMQRHGHTVEALTNR

Download         Length: 222 bp

>AT140158 NZ_CP058991:c857032-856748 [Pasteurella multocida]
GTGGGTCGGTTAAGGGAGGTAAAAAATTTATCCGCCAAAGCCGCTGTTCTTGCTCGTATTAACAGAGTAATGAATGGTAA
TTTGGGCGATCATAAATCGATTGGAAATGGATTGTATGAGATGAGAATTATAAAAGGTTCGGGTTATAGAGTTTACTATG
GACAATATAGAGAAGTAACTTATTTATTAATTTGTGGTGGCGATAAATCAACACAGAAATCAGACATTGTTAAAGCGAGA
GAGTTGTGGAAAGAAATAAAGCAACAAGAGGAAGTAAAAGTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2X2BIG8

Antitoxin

Source ID Structure
AlphaFold DB A0A1Z1SPN9

References