140148

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1686518..1687106 Replicon chromosome
Accession NZ_CP044125
Organism Rhizobium sp. BG4

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag F2982_RS08790 Protein ID WP_199629863.1
Coordinates 1686518..1686700 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag F2982_RS08795 Protein ID WP_203429835.1
Coordinates 1686711..1687106 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F2982_RS08760 1681868..1682338 - 471 WP_203429832.1 hypothetical protein -
F2982_RS08765 1682461..1683096 + 636 WP_112714190.1 trimeric intracellular cation channel family protein -
F2982_RS08770 1683100..1683519 - 420 WP_130279385.1 transcriptional repressor -
F2982_RS08775 1683820..1684326 + 507 WP_203429833.1 3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabA -
F2982_RS08780 1684380..1685603 + 1224 WP_112714194.1 beta-ketoacyl-ACP synthase I -
F2982_RS08785 1685608..1686414 + 807 WP_203429834.1 enoyl-ACP reductase FabI -
F2982_RS08790 1686518..1686700 + 183 WP_199629863.1 type II toxin-antitoxin system HicA family toxin Toxin
F2982_RS08795 1686711..1687106 + 396 WP_203429835.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
F2982_RS08800 1687110..1688126 - 1017 WP_203429836.1 class I SAM-dependent methyltransferase -
F2982_RS08805 1688202..1690339 - 2138 Protein_1729 polyribonucleotide nucleotidyltransferase -
F2982_RS08810 1690671..1690940 - 270 WP_026283114.1 30S ribosomal protein S15 -
F2982_RS08815 1691110..1692042 - 933 WP_203429837.1 tRNA pseudouridine(55) synthase TruB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(4-124)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6726.87 Da        Isoelectric Point: 11.9924

>T140148 WP_199629863.1 NZ_CP044125:1686518-1686700 [Rhizobium sp. BG4]
MERNSQKIISRLKRDGFALISVKGSHHKFRKGDRTIIVPHPKKDLPAGTAHAIARQAGWV

Download         Length: 183 bp

>T140148 NZ_CP058960:c5434986-5434603 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14336.17 Da        Isoelectric Point: 4.3257

>AT140148 WP_203429835.1 NZ_CP044125:1686711-1687106 [Rhizobium sp. BG4]
MKYFIALVHKDEDSAFGISFPDLPSVFSAADKEDDLTANAIEALRLWAEDEVLPVPSSFETISSRADVREQLAAGAFLTR
VPFIEDETRIVRANVTFEKGMLDAIDAAAKERGLTRSAFLASAARKEIEAA

Download         Length: 396 bp

>AT140148 NZ_CP058960:c5435228-5434986 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References