140139

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapC-vagC/VapC-VagC
Location 1039968..1040605 Replicon chromosome
Accession NZ_CP044123
Organism Agrobacterium rhizogenes strain LBA9402

Toxin (Protein)


Gene name vapC Uniprot ID A0A5M8ULE8
Locus tag F3X89_RS23875 Protein ID WP_034515896.1
Coordinates 1040204..1040605 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID B9JLI6
Locus tag F3X89_RS23870 Protein ID WP_007702100.1
Coordinates 1039968..1040204 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F3X89_RS23855 1035199..1035849 - 651 WP_047468486.1 TetR/AcrR family transcriptional regulator -
F3X89_RS23860 1035977..1037266 + 1290 WP_047525154.1 MFS transporter -
F3X89_RS23865 1037340..1039796 + 2457 WP_174016077.1 beta-glucosidase -
F3X89_RS23870 1039968..1040204 + 237 WP_007702100.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
F3X89_RS23875 1040204..1040605 + 402 WP_034515896.1 type II toxin-antitoxin system VapC family toxin Toxin
F3X89_RS23880 1040732..1041829 - 1098 WP_015917978.1 branched-chain amino acid aminotransferase -
F3X89_RS23885 1041979..1042893 - 915 WP_034515897.1 DUF1194 domain-containing protein -
F3X89_RS23890 1042913..1043530 - 618 WP_015917976.1 LysE family translocator -
F3X89_RS23895 1043752..1044411 - 660 WP_007702087.1 response regulator transcription factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-117)

Antitoxin

SpoVT-AbrB domain

(7-46)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14951.22 Da        Isoelectric Point: 5.6421

>T140139 WP_034515896.1 NZ_CP044123:1040204-1040605 [Agrobacterium rhizogenes]
MPRYMLDTNMCIYLMKNQPEQVARRFAACYVGDVVMSAITFAELDYGVAASDAPERERGNLDALVTLIAVEPFDIAAAHA
YGPVRMATRERKKDHLDKLIASHAIALNTVLVTNNTRDFMAYPNLKIENWLDT

Download         Length: 402 bp

>T140139 NZ_CP058960:350588-350935 [Klebsiella pneumoniae]
ATGTGGGATGTAGAAACGACGGATACGTTTGATGCCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATGCTCATCCTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTGCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTGTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGTGGGCAATAAGGATGGCATGAATGAGAAACGTTTTTACAAAGAGATGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 9020.18 Da        Isoelectric Point: 4.6561

>AT140139 WP_007702100.1 NZ_CP044123:1039968-1040204 [Agrobacterium rhizogenes]
MQMTKAFKNGNSQAVRIPAEIAYERTDMELEIERVGDEIRIRPVRQSLAGVMDVFARFSPNFMSEGRGDQEQDEREKI

Download         Length: 237 bp

>AT140139 NZ_CP058960:350935-351234 [Klebsiella pneumoniae]
ATGGCCACGCTAAAAGAACTCATGGCGAAACAGAGTCCTGATAGCCAGCAGCGTATTGCAGCGAAAGCGGCAGAGATACG
CCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGAGATGGCTGCGGCTATGGGGGTAAAGC
AGCCAACGATCGCTAAAATGGAACAGGCTGATAACGACCCTCGGCTTTCGACCCTAAAACGCTACATTGCGGCATTGGGG
GGAGAACTCAGTATAAATGTCACATTGCCGACTGGAAAAAAAGTCTCGTTTAATTTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5M8ULE8

Antitoxin

Source ID Structure
AlphaFold DB A0A5M8UQQ5

References