Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 3943038..3943672 Replicon chromosome
Accession NZ_CP044122
Organism Agrobacterium rhizogenes strain LBA9402

Toxin (Protein)


Gene name vapC Uniprot ID B9J7R8
Locus tag F3X89_RS19170 Protein ID WP_012650858.1
Coordinates 3943038..3943433 (-) Length 132 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID B9J7R9
Locus tag F3X89_RS19175 Protein ID WP_007702738.1
Coordinates 3943430..3943672 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F3X89_RS19140 3938053..3938508 + 456 WP_007702750.1 ester cyclase -
F3X89_RS19145 3938571..3939335 - 765 WP_007702749.1 SDR family oxidoreductase -
F3X89_RS19150 3939455..3940360 + 906 WP_007702748.1 LysR family transcriptional regulator -
F3X89_RS19155 3940361..3941236 - 876 WP_007702747.1 LysR family transcriptional regulator -
F3X89_RS19160 3941334..3942617 + 1284 WP_034520082.1 MFS transporter -
F3X89_RS19165 3942640..3943041 + 402 WP_012650857.1 VOC family protein -
F3X89_RS19170 3943038..3943433 - 396 WP_012650858.1 type II toxin-antitoxin system VapC family toxin Toxin
F3X89_RS19175 3943430..3943672 - 243 WP_007702738.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
F3X89_RS19180 3943741..3944418 - 678 WP_007702735.1 spermidine synthase -
F3X89_RS19185 3944489..3946150 - 1662 WP_007702732.1 urocanate hydratase -
F3X89_RS19190 3946174..3946503 - 330 WP_203469668.1 cold-shock protein -
F3X89_RS19195 3946519..3947619 - 1101 WP_007702725.1 DUF917 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-121)

Antitoxin

SpoVT-AbrB domain

(7-43)


Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14662.84 Da        Isoelectric Point: 6.8818

>T140137 WP_012650858.1 NZ_CP044122:c3943433-3943038 [Agrobacterium rhizogenes]
VKYLLDSNAVIALMKGHSGFVAEIRKHKPQDFAIPAIVAHELFYGAYKGQRVADNLARVDALQFETLDFDREDARKAGEI
RAALAILGTPIGAYDVLIAGQAVARDLILVTHNVREFQRVKNLRFEDWETV

Download         Length: 396 bp

>T140137 NZ_CP058958:c4355473-4355171 [Providencia rettgeri]
ATGATCACGGTTCTAACAACGGAATGTTTTGATAGTTGGATCAAAAATCTTAGAGATATTCGAGCTAAAACTAAAATTCT
AATGAGAATTAGGCGGTTAAAAAATGGAAATTATGGTGATGTTCAACCCATTGGTGATGGCTTTTCGGAACTGAGGGTAC
ATGAAGGACAAGGGTATCGTGTTTATCTAAAGCAGAAAAACAATGTTATTGTAATTTTACTTTGTGGTGGGACAAAGGCA
ACGCAGCAGAAGGATATCCATAAAGCTAAACTCCTTTTTGGTGAAGTTGAGGGGGAACTATGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9333.46 Da        Isoelectric Point: 4.1849

>AT140137 WP_007702738.1 NZ_CP044122:c3943672-3943430 [Agrobacterium rhizogenes]
MDTAKIFWSGRSQAVRLPKEFRFDTDAVRIRRQGQAIILEPIVEDWDWLETVTGPVDQDFAEAATEQPVEQERPELDIFK

Download         Length: 243 bp

>AT140137 NZ_CP058958:c4355174-4354890 [Providencia rettgeri]
ATGAATACTAAATTAAAAGAATTTGATATCGCTGAGTATTTAAACAGTGAAGAAGAAATACAAATGTATCTAAACGAAAT
TCTAGAAGAAGGTGACCCTAGTCTAGTTCTCGCTGCACTTGGTGATATTGCGAAGGCAAGAAATATGAGCCAATTAGCTA
AAGAAGTTGGAATGAGTCGTGAAGGTTTATATAAGGCGCTATCAGGACAGGGAAATCCAACATTTATGACGATTATAAAA
ATCGTTAATTCTCTCGGATTAAAGCTACAGTTTAAGAGTATCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5M8UNI2

Antitoxin

Source ID Structure
AlphaFold DB A0A5M8UM92

References