Detailed information of TA system TA140136

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-parE/RHH(antitoxin)
• Location: 3737734..3738299
• Replicon: chromosome
• Accession: NZ_CP044122
• Organism: Agrobacterium rhizogenes strain LBA9402

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: F3X89_RS18100
• Protein ID: WP_198929354.1
• Coordinates: 3738054..3738299 (+)
• Length: 82 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: B9J6S6
• Locus tag: F3X89_RS18095
• Protein ID: WP_007702948.1
• Coordinates: 3737734..3738018 (+)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
F3X89_RS18080	3733542..3735179	+	1638	WP_007702958.1	ABC transporter ATP-binding protein	-
F3X89_RS18085	3735191..3736150	+	960	WP_007702954.1	glyoxylate/hydroxypyruvate reductase A	-
F3X89_RS18090	3736342..3737646	+	1305	WP_007702951.1	nicotinate phosphoribosyltransferase	-
F3X89_RS18095	3737734..3738018	+	285	WP_007702948.1	hypothetical protein	Antitoxin
F3X89_RS18100	3738054..3738299	+	246	WP_198929354.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
F3X89_RS18105	3738310..3739302	-	993	WP_113136710.1	hypothetical protein	-
F3X89_RS18110	3739445..3741619	+	2175	WP_007702939.1	mechanosensitive ion channel	-
F3X89_RS18115	3741704..3742774	-	1071	WP_039974897.1	LacI family transcriptional regulator	-
F3X89_RS18120	3742914..3743210	+	297	WP_007702934.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-78)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9244.71 Da
• Isoelectric Point: 10.0946

>T140136 WP_198929354.1 NZ_CP044122:3738054-3738299 [Agrobacterium rhizogenes]
MRQFLQPKNAASAKKASTKIIQTIQMLSNQPDMGRPVEDLHQGLRELIVKFGRDGYVVLYRYIGDEVLIAAIRHGREDGY
K

Nucleotide

• Length: 246 bp

>T140136 NZ_CP058958:c4355174-4354890 [Providencia rettgeri]
ATGAATACTAAATTAAAAGAATTTGATATCGCTGAGTATTTAAACAGTGAAGAAGAAATACAAATGTATCTAAACGAAAT
TCTAGAAGAAGGTGACCCTAGTCTAGTTCTCGCTGCACTTGGTGATATTGCGAAGGCAAGAAATATGAGCCAATTAGCTA
AAGAAGTTGGAATGAGTCGTGAAGGTTTATATAAGGCGCTATCAGGACAGGGAAATCCAACATTTATGACGATTATAAAA
ATCGTTAATTCTCTCGGATTAAAGCTACAGTTTAAGAGTATCTAA

Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 10784.99 Da
• Isoelectric Point: 4.4877

>AT140136 WP_007702948.1 NZ_CP044122:3737734-3738018 [Agrobacterium rhizogenes]
MSSALKASVKIDPEVNERLEKLAASRHRQPDLLLKEAVEQYVDREEKRDSLLRDGRLSLDEYEATGLHVTGDEVIAWLET
WGDEDEKAPPECHR

Nucleotide

• Length: 285 bp

>AT140136 NZ_CP058958:c4355473-4355171 [Providencia rettgeri]
ATGATCACGGTTCTAACAACGGAATGTTTTGATAGTTGGATCAAAAATCTTAGAGATATTCGAGCTAAAACTAAAATTCT
AATGAGAATTAGGCGGTTAAAAAATGGAAATTATGGTGATGTTCAACCCATTGGTGATGGCTTTTCGGAACTGAGGGTAC
ATGAAGGACAAGGGTATCGTGTTTATCTAAAGCAGAAAAACAATGTTATTGTAATTTTACTTTGTGGTGGGACAAAGGCA
ACGCAGCAGAAGGATATCCATAAAGCTAAACTCCTTTTTGGTGAAGTTGAGGGGGAACTATGA

Structures

Antitoxin

• AlphaFold DB: A0A5M8UMH1