Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3417346..3418003 Replicon chromosome
Accession NZ_CP044121
Organism Raoultella planticola strain S25

Toxin (Protein)


Gene name cptA Uniprot ID A0A2X2EG10
Locus tag F3X94_RS16540 Protein ID WP_032690815.1
Coordinates 3417346..3417756 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A514ELX1
Locus tag F3X94_RS16545 Protein ID WP_004867358.1
Coordinates 3417737..3418003 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F3X94_RS16520 3413267..3415000 - 1734 WP_032696678.1 single-stranded-DNA-specific exonuclease RecJ -
F3X94_RS16525 3415006..3415719 - 714 WP_032690818.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
F3X94_RS16530 3415742..3416638 - 897 WP_032690817.1 site-specific tyrosine recombinase XerD -
F3X94_RS16535 3416817..3417338 + 522 WP_032690816.1 flavodoxin FldB -
F3X94_RS16540 3417346..3417756 - 411 WP_032690815.1 protein YgfX Toxin
F3X94_RS16545 3417737..3418003 - 267 WP_004867358.1 FAD assembly factor SdhE Antitoxin
F3X94_RS16550 3418300..3419283 + 984 WP_047663460.1 tRNA-modifying protein YgfZ -
F3X94_RS16555 3419393..3420052 - 660 WP_004867362.1 hemolysin III family protein -
F3X94_RS16560 3420214..3420525 - 312 WP_004867365.1 N(4)-acetylcytidine aminohydrolase -
F3X94_RS16565 3420575..3421303 + 729 WP_032690813.1 MurR/RpiR family transcriptional regulator -
F3X94_RS16570 3421423..3422856 + 1434 WP_032690812.1 6-phospho-beta-glucosidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16198.10 Da        Isoelectric Point: 11.3349

>T140131 WP_032690815.1 NZ_CP044121:c3417756-3417346 [Raoultella planticola]
VVLWQSDLRISWRSQWFSLLLHGIVAAIVLLMPWPLSYTPLWLLLLSLVVFDSVRSQRRIHACRGEIKLMTDSRLRWQKA
EWEIVGTPWVINSGMLLRLQDMQTRRRQHLWVAADSMDAKEWRDLRRLVLQKPAQD

Download         Length: 411 bp

>T140131 NZ_CP058958:1530780-1531190 [Providencia rettgeri]
GTGGTCCTGTGGAAATCTAATCTCTCCATTTCATGGAAAACCCAACTGTTCTCAACCTGTGTTCATGGGGTCATTGGGAT
GTTTTTACTATTGGCTCCATGGTCCCCTGGTAACTCAATGATATGGTTGCCGCTATTAGTGGTTGTCGTTGCGAGTTGGG
CAAAGAGCCAGAAAAATATCAGTAAAATAAAAGGGGTTGCTGTACTGGTTAATGGCAATAAGGTTCAGTGGAAGAAAAAT
GAATGGAGAATACTGAAAGCACCTTGGCTTACCCGCTATGGTATATTACTGACACTAGAAGCGTTACAAGGTAAACCACA
AAAGCTCCATTTGTGGGTTGCAAAAGACGCATTGTCGGAAGAGAATTGGCGTAATTTAAACCAATTATTGCTGCAATACC
CTGATATTTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10553.05 Da        Isoelectric Point: 4.8432

>AT140131 WP_004867358.1 NZ_CP044121:c3418003-3417737 [Raoultella planticola]
MDITNKARIHWACRRGMRELDISIMPFFEYEYDTLSDEDKQLFIRLLENDDPDLFNWLMNHGEPADAQLQRMVKLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT140131 NZ_CP058958:1530533-1530799 [Providencia rettgeri]
ATGGATATTGAGAATAAAGCGCGAATTCATTGGGCATGCCGCCGTGGTATGCGTGAATTAGATATTTCAATCATGCCGTT
TTTTGAGTATGAATATGATGACCTAACAACTCACGATAAGCAGGTATTTGTCCGTTTATTAGAATGTGCGGACCCTGATT
TATTCAATTGGCTAATGAATCACGGTCGTCCAGATGATGACGAACTTTTTCGTATGATTAAACTGATTCAGGAAAAAAAT
AAAAATCGTGGTCCTGTGGAAATCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2X2EG10

Antitoxin

Source ID Structure
AlphaFold DB A0A514ELX1

References