Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-MazE
Location 41643..42283 Replicon chromosome
Accession NZ_CP044115
Organism Roseomonas mucosa strain FDAARGOS_658

Toxin (Protein)


Gene name vapC Uniprot ID A0A379PMP7
Locus tag FOB66_RS01555 Protein ID WP_019463224.1
Coordinates 41876..42283 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A379PNA3
Locus tag FOB66_RS01550 Protein ID WP_019463225.1
Coordinates 41643..41879 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOB66_RS01535 38311..39264 + 954 WP_115359383.1 IS630 family transposase -
FOB66_RS01540 39294..40570 + 1277 WP_085977433.1 IS3 family transposase -
FOB66_RS01545 40587..41360 - 774 WP_026033587.1 hypothetical protein -
FOB66_RS01550 41643..41879 + 237 WP_019463225.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
FOB66_RS01555 41876..42283 + 408 WP_019463224.1 PIN domain-containing protein Toxin
FOB66_RS01560 42280..43404 + 1125 WP_019463223.1 site-specific integrase -
FOB66_RS01565 43517..43741 + 225 WP_019463222.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
FOB66_RS01570 43738..44148 + 411 WP_019463221.1 type II toxin-antitoxin system VapC family toxin -
FOB66_RS01575 44206..46881 + 2676 WP_167522604.1 CRISPR-associated helicase Cas3' -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-115)

Antitoxin

SpoVT-AbrB domain

(5-36)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 14660.95 Da        Isoelectric Point: 6.9526

>T140119 WP_019463224.1 NZ_CP044115:41876-42283 [Roseomonas mucosa]
MNRPFLDTNILLYAALQPDPRSETARGLLARGGLVSVQVLNEFTAVARRKLRRPWPEVMQALAAIRTLCPAPRPLTVATH
EAAIGLAERLGYTIDNALILASALEAGCDTLFSEDLQDGQVVEGRLTIRNPFAAP

Download         Length: 408 bp

>T140119 NZ_CP058948:c3347243-3346908 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8666.71 Da        Isoelectric Point: 6.4685

>AT140119 WP_019463225.1 NZ_CP044115:41643-41879 [Roseomonas mucosa]
MQVSRWGNSLAVRLPAAVVEALGLREGDEVAIEVAGPHTFRVARDRRRDEAIEALRGLGWHLPDGFRFSRDEANERGG

Download         Length: 237 bp

>AT140119 NZ_CP058948:c3347491-3347243 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A379PMP7

Antitoxin

Source ID Structure
AlphaFold DB A0A379PNA3

References