Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4637331..4637951 Replicon chromosome
Accession NZ_CP044107
Organism Enterobacter hormaechei strain FDAARGOS_642

Toxin (Protein)


Gene name Hha Uniprot ID A0A837FFM2
Locus tag FOB50_RS22040 Protein ID WP_015571250.1
Coordinates 4637733..4637951 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID F5RUW7
Locus tag FOB50_RS22035 Protein ID WP_006809850.1
Coordinates 4637331..4637705 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOB50_RS22025 4632458..4633651 + 1194 WP_017694395.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
FOB50_RS22030 4633674..4636820 + 3147 WP_015571248.1 multidrug efflux RND transporter permease subunit -
FOB50_RS22035 4637331..4637705 + 375 WP_006809850.1 Hha toxicity modulator TomB Antitoxin
FOB50_RS22040 4637733..4637951 + 219 WP_015571250.1 hemolysin expression modulator Hha Toxin
FOB50_RS22045 4638160..4638711 + 552 WP_032670459.1 maltose O-acetyltransferase -
FOB50_RS22050 4638828..4639295 + 468 WP_017383209.1 membrane protein -
FOB50_RS22055 4639267..4640727 - 1461 WP_032620143.1 PLP-dependent aminotransferase family protein -
FOB50_RS22060 4640829..4641539 + 711 WP_023303201.1 GNAT family N-acetyltransferase -
FOB50_RS22065 4641536..4641676 - 141 WP_003859006.1 type B 50S ribosomal protein L36 -
FOB50_RS22070 4641679..4641939 - 261 WP_015571255.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8583.95 Da        Isoelectric Point: 8.9008

>T140116 WP_015571250.1 NZ_CP044107:4637733-4637951 [Enterobacter hormaechei]
MSDKPLTKVDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFVR

Download         Length: 219 bp

>T140116 NZ_CP058948:c2521973-2521722 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATCATTGAGTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14497.28 Da        Isoelectric Point: 4.8989

>AT140116 WP_006809850.1 NZ_CP044107:4637331-4637705 [Enterobacter hormaechei]
MDEYSPKRHDIAQLKFLCESLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFTNVSRANPVSLSC

Download         Length: 375 bp

>AT140116 NZ_CP058948:c2521725-2521471 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGACGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837FFM2

Antitoxin

Source ID Structure
AlphaFold DB A0A837FGN8

References