Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1946009..1946666 Replicon chromosome
Accession NZ_CP044107
Organism Enterobacter hormaechei strain FDAARGOS_642

Toxin (Protein)


Gene name cptA Uniprot ID A0A179PSF7
Locus tag FOB50_RS09340 Protein ID WP_017382887.1
Coordinates 1946256..1946666 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID G8LDB7
Locus tag FOB50_RS09335 Protein ID WP_003863437.1
Coordinates 1946009..1946275 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOB50_RS09315 1941415..1942848 - 1434 WP_017382891.1 6-phospho-beta-glucosidase BglA -
FOB50_RS09320 1942965..1943696 - 732 WP_015571796.1 MurR/RpiR family transcriptional regulator -
FOB50_RS09325 1943963..1944622 + 660 WP_003863433.1 hemolysin III family protein -
FOB50_RS09330 1944734..1945714 - 981 WP_032669268.1 tRNA-modifying protein YgfZ -
FOB50_RS09335 1946009..1946275 + 267 WP_003863437.1 FAD assembly factor SdhE Antitoxin
FOB50_RS09340 1946256..1946666 + 411 WP_017382887.1 protein YgfX Toxin
FOB50_RS09345 1946668..1947189 - 522 WP_015571793.1 flavodoxin FldB -
FOB50_RS09350 1947291..1948187 + 897 WP_003863442.1 site-specific tyrosine recombinase XerD -
FOB50_RS09355 1948216..1948929 + 714 WP_150390928.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
FOB50_RS09360 1948935..1950668 + 1734 WP_017382886.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16321.21 Da        Isoelectric Point: 11.4775

>T140106 WP_017382887.1 NZ_CP044107:1946256-1946666 [Enterobacter hormaechei]
VVLWQSDLRVSWRSQWMSLLLHGLVAALVLLVPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWEMMGTPWMLNTGMMLRLRRVEDNRRQHLWLAADSMDPAEWRDLRRLIVQQPTQE

Download         Length: 411 bp

>T140106 NZ_CP058948:c1702172-1702065 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10526.96 Da        Isoelectric Point: 4.8310

>AT140106 WP_003863437.1 NZ_CP044107:1946009-1946275 [Enterobacter hormaechei]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
QERGPVAI

Download         Length: 267 bp

>AT140106 NZ_CP058948:1702220-1702286 [Escherichia coli]
GTTCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTGTACCTCTCAACGTGCGGGGGTTTTCTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A179PSF7

Antitoxin

Source ID Structure
AlphaFold DB A0A837F8P5

References