140100

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 1433299..1433776 Replicon chromosome
Accession NZ_CP044106
Organism Staphylococcus aureus strain FDAARGOS_660

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag FOB68_RS07545 Protein ID WP_000052076.1
Coordinates 1433588..1433776 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag FOB68_RS07540 Protein ID WP_001059690.1
Coordinates 1433299..1433559 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOB68_RS07505 1428692..1429408 - 717 WP_000150029.1 type I 3-dehydroquinate dehydratase -
FOB68_RS07510 1429556..1429978 + 423 WP_000974455.1 organic hydroperoxide resistance protein -
FOB68_RS07515 1430377..1430871 + 495 WP_000569881.1 GNAT family N-acetyltransferase -
FOB68_RS07520 1431027..1431644 + 618 WP_000255554.1 LysE/ArgO family amino acid transporter -
FOB68_RS07525 1431717..1432298 - 582 WP_001140697.1 phosphoglycerate mutase family protein -
FOB68_RS07530 1432522..1432758 + 237 WP_000368687.1 hypothetical protein -
FOB68_RS07535 1432755..1432958 - 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
FOB68_RS07540 1433299..1433559 + 261 WP_001059690.1 hypothetical protein Antitoxin
FOB68_RS07545 1433588..1433776 + 189 WP_000052076.1 hypothetical protein Toxin
FOB68_RS07550 1433964..1434533 + 570 WP_001106657.1 hypothetical protein -
FOB68_RS07555 1434621..1434905 + 285 WP_001004397.1 hypothetical protein -
FOB68_RS07560 1434967..1435185 + 219 WP_000005888.1 hypothetical protein -
FOB68_RS07565 1435684..1435884 - 201 WP_001059082.1 cold-shock protein -
FOB68_RS07570 1436241..1436927 - 687 WP_001823812.1 thermonuclease family protein -
FOB68_RS07575 1437268..1437738 - 471 WP_000824462.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - seb / selq / selk / vWbp 1403829..1451755 47926


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Type I toxin-antitoxin system, toxin Ldr

(1-35)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T140100 WP_000052076.1 NZ_CP044106:1433588-1433776 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T140100 NZ_CP058948:183643-183750 [Escherichia coli]
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT140100 WP_001059690.1 NZ_CP044106:1433299-1433559 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT140100 NZ_CP058948:c183594-183528 [Escherichia coli]
GTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References