Detailed information of TA system TA140099

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TscAT/-
• Location: 1413629..1414161
• Replicon: chromosome
• Accession: NZ_CP044106
• Organism: Staphylococcus aureus strain FDAARGOS_660

Toxin (Protein)

• Gene name: TscT
• Uniprot ID: Q93CD4
• Locus tag: FOB68_RS07390
• Protein ID: WP_001103942.1
• Coordinates: 1413629..1413949 (-)
• Length: 107 a.a.

Antitoxin (Protein)

• Gene name: TscA
• Uniprot ID: -
• Locus tag: FOB68_RS07395
• Protein ID: WP_001058486.1
• Coordinates: 1413952..1414161 (-)
• Length: 70 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FOB68_RS07355	1408780..1409121	-	342	WP_001190615.1	hypothetical protein	-
FOB68_RS07360	1409638..1410279	-	642	WP_001019764.1	hypothetical protein	-
FOB68_RS07365	1410276..1410560	-	285	WP_000998181.1	hypothetical protein	-
FOB68_RS07370	1410562..1410924	-	363	WP_001039168.1	hypothetical protein	-
FOB68_RS07380	1411210..1412679	-	1470	WP_000390454.1	virulence-associated E family protein	-
FOB68_RS07385	1412696..1413565	-	870	WP_001002732.1	primase alpha helix C-terminal domain-containing protein	-
FOB68_RS07390	1413629..1413949	-	321	WP_001103942.1	DUF1474 family protein	Toxin
FOB68_RS07395	1413952..1414161	-	210	WP_001058486.1	hypothetical protein	Antitoxin
FOB68_RS07400	1414154..1414300	-	147	WP_000784875.1	hypothetical protein	-
FOB68_RS07405	1414312..1414584	-	273	WP_000091731.1	helix-turn-helix domain-containing protein	-
FOB68_RS07410	1414577..1414840	-	264	WP_000243851.1	helix-turn-helix domain-containing protein	-
FOB68_RS07415	1415033..1415365	+	333	WP_001260004.1	helix-turn-helix transcriptional regulator	-
FOB68_RS07420	1415377..1415835	+	459	WP_150344386.1	ImmA/IrrE family metallo-endopeptidase	-
FOB68_RS07425	1415852..1416283	+	432	WP_001228759.1	hypothetical protein	-
FOB68_RS07430	1416353..1417081	+	729	WP_001033316.1	staphylococcal enterotoxin type Q	-
FOB68_RS07435	1417105..1417833	+	729	WP_000733774.1	staphylococcal enterotoxin type K	-
FOB68_RS07440	1417922..1419142	+	1221	WP_000266157.1	site-specific integrase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	seb / selq / selk / vWbp	1403829..1451755	47926

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF1474 (1-98)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 107 a.a.
• Molecular weight: 12694.22 Da
• Isoelectric Point: 4.7419

>T140099 WP_001103942.1 NZ_CP044106:c1413949-1413629 [Staphylococcus aureus]
MNWEIKDLMCDIEVIKQKINDVATKHAWFVEDRFVKNELETKREHINFSASYLEHRIQNEHTVELLHVYLKEFSELIQKF
HEIEKASSENFDEESDDAKNSIKVAE

Nucleotide

• Length: 321 bp

>T140099 NZ_CP058943:46243-46659 [Klebsiella pneumoniae]
GTGAACAAGACCTATATGCTCGACACCTGTATCTGCTCGTTCATCATGCGCGAGCAGCCGGAAGCCGTCCTGAAGCGCCT
GGAGCAGGCGGTGCTGCGCGGCCAGCGCATCGTTGTCTCGGCCATCACTTATTCTGAAATGCGCTTCGGGGCCACCGGCC
CGAAGGCCTCCCCGCGCCACGTCGAGCTGGTCGACGCGTTCTGCGCCCGCCTCGATGCCATCCTGCCCTGGGATCGCGCT
GCGGTGGACGCCACCACGGAGATTAAGGTGGCGCTGCGAATGGCCGGGACGCCGATCGGCCCGAACGACACGGCCATTGC
CGGGCACGCCATCGCCGCCGGTGCCGTGCTGGTGACGAATAATACGCGGGAATTTGAGCGGGTACCGGGTCTTGTGCTGG
AAGACTGGGTAAGATAA

Antitoxin

Protein

• Length: 70 a.a.
• Molecular weight: 8252.31 Da
• Isoelectric Point: 4.3718

>AT140099 WP_001058486.1 NZ_CP044106:c1414161-1413952 [Staphylococcus aureus]
MNNEQKEVIEHLVYQLELSVMNNLESYEHTEYVNGIEVVSEISREKHLELIMKWCAQELKNNFQLEKGE

Nucleotide

• Length: 210 bp

>AT140099 NZ_CP058943:46016-46246 [Klebsiella pneumoniae]
ATGAGAACTGTATCCATTTTTAAAAACGGCAATAACCGCGCCATTCGTCTGCCCCGCGATCTGGATTTTGAGGGAGTGAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATTATTTTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGTTCG
AGAAGGCAGACCCGGACTTTATGGCGGAGCGCGAGGACGTTGTCAGCGACGAAGGACGATTTAACCTGTGA

Structures

Toxin

• AlphaFold DB: Q93CD4