140092

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 155205..155719 Replicon chromosome
Accession NZ_CP044106
Organism Staphylococcus aureus strain FDAARGOS_660

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag FOB68_RS00995 Protein ID WP_000581792.1
Coordinates 155510..155719 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A0D1GBN9
Locus tag FOB68_RS00990 Protein ID WP_000138934.1
Coordinates 155205..155498 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOB68_RS00950 150466..151107 + 642 WP_000483147.1 thiamine phosphate synthase -
FOB68_RS00955 151193..152065 + 873 WP_000725802.1 membrane protein insertase YidC -
FOB68_RS00980 152880..153527 - 648 WP_001187610.1 HD domain-containing protein -
FOB68_RS00985 153555..155039 - 1485 WP_000571549.1 cardiolipin synthase -
FOB68_RS00990 155205..155498 + 294 WP_000138934.1 copper-sensing transcriptional repressor CsoR Antitoxin
FOB68_RS00995 155510..155719 + 210 WP_000581792.1 heavy-metal-associated domain-containing protein Toxin
FOB68_RS01000 155847..155984 + 138 WP_000828354.1 hypothetical protein -
FOB68_RS01005 156248..157450 - 1203 WP_001109939.1 rod shape-determining protein RodA -
FOB68_RS01010 157768..158838 + 1071 WP_000159641.1 D-alanine--D-alanine ligase -
FOB68_RS01015 158853..160211 + 1359 WP_000611468.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(3-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T140092 WP_000581792.1 NZ_CP044106:155510-155719 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T140092 NZ_CP058940:c1805334-1804951 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGTACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGAAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11185.77 Da        Isoelectric Point: 6.2243

>AT140092 WP_000138934.1 NZ_CP044106:155205-155498 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVATKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT140092 NZ_CP058940:c1805576-1805334 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB A0A0D1GBN9

References