Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1094978..1095464 Replicon chromosome
Accession NZ_CP044102
Organism Streptococcus dysgalactiae strain FDAARGOS_654

Toxin (Protein)


Gene name relE Uniprot ID Q48QR0
Locus tag FOB62_RS05585 Protein ID WP_014407961.1
Coordinates 1095195..1095464 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A660A1J7
Locus tag FOB62_RS05580 Protein ID WP_014407962.1
Coordinates 1094978..1095205 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOB62_RS05535 1090751..1090924 + 174 WP_003045773.1 hypothetical protein -
FOB62_RS11230 1090930..1091103 + 174 WP_012767665.1 hypothetical protein -
FOB62_RS05540 1091105..1091431 + 327 Protein_1043 hypothetical protein -
FOB62_RS05545 1091427..1091672 + 246 WP_012767663.1 hypothetical protein -
FOB62_RS11235 1091686..1091835 + 150 WP_012767662.1 hypothetical protein -
FOB62_RS05550 1091924..1092709 + 786 WP_012767661.1 hypothetical protein -
FOB62_RS05555 1092719..1092967 + 249 WP_012767660.1 hypothetical protein -
FOB62_RS05560 1093050..1093388 + 339 WP_012767659.1 hypothetical protein -
FOB62_RS05565 1093378..1093649 + 272 Protein_1049 hypothetical protein -
FOB62_RS11240 1093626..1093847 + 222 WP_012767657.1 hypothetical protein -
FOB62_RS05570 1094118..1094480 + 363 WP_012767656.1 DUF1492 domain-containing protein -
FOB62_RS05575 1094455..1094841 + 387 WP_012767655.1 DUF1492 domain-containing protein -
FOB62_RS05580 1094978..1095205 + 228 WP_014407962.1 hypothetical protein Antitoxin
FOB62_RS05585 1095195..1095464 + 270 WP_014407961.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FOB62_RS05590 1095892..1097394 + 1503 WP_014612646.1 IS1182 family transposase -
FOB62_RS05595 1097391..1097924 - 534 WP_003059589.1 TetR/AcrR family transcriptional regulator C-terminal domain-containing protein -
FOB62_RS05600 1098059..1100332 + 2274 WP_150336228.1 YhgE/Pip domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 1058633..1123025 64392
- flank IS/Tn - - 1095892..1097394 1502


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-87)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10497.50 Da        Isoelectric Point: 10.5027

>T140086 WP_014407961.1 NZ_CP044102:1095195-1095464 [Streptococcus dysgalactiae]
MTYKLVVSDEVKKQLKKMDKHVGLMLAKDMKKRLDGLNNPRQFGKALTGQYKGLWRYRVGNYRVICDIVDNEMIILALEV
GHRKEIYKR

Download         Length: 270 bp

>T140086 NZ_CP058908:235604-236023 [Pseudomonas phenolilytica]
ATGATCTTGCTTGATACCAATGTGTTGTCCGAGCTCATGCGAGCCAAGCCGGCGCCGCAAGTAATTGAGTGGGTCGACGC
CCAGCCAGCGAGCGAGTTAGCGATCAGTGCGATCACTGTTGCGGAGATTCTTTACGGCATTGCCAGAATGCCGGATGGCA
AGCGCAAACAAGGGCTGCTCGACATAGCCTCGGCCATGTTTGAGGAAGATTTCGCCGGCAATATCCTGCCGTTCGATGCA
GACGCAGCCGTCCACTACGCAGAGATTGCTGCCGCGACCGAAGCGAAGGGGCGAATAGTAGATATGGCAGATGCGCAGAT
CGCCGCGATTGGACGGCGACACGATGCCATCATCGCGACTCGCAATACCCGTCATTTCGAGCCGTTGGGAGTGGCTTTGA
TCGATCCCTGGAGCGAATAG

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8641.63 Da        Isoelectric Point: 3.9607

>AT140086 WP_014407962.1 NZ_CP044102:1094978-1095205 [Streptococcus dysgalactiae]
MAMVSLRLNSAEEELFRSYATHTGKTLSELFKTALAQQIEDQLDYETGIQALKRFEENPITYSIDDLIEELENDL

Download         Length: 228 bp

>AT140086 NZ_CP058908:235362-235607 [Pseudomonas phenolilytica]
ATGGCCAGCATTACGATCCGAAACCTTGACGACGACCTGAAGGCGAAATTGCGCGTTGTAGCGGCTAGTCATGGACGCTC
GATGGAAGAAGAAGCCCGAATCATCATTCGGCAAGCCCTGTCGCGTCAGGAAAAGCGTGGCGGACTGGGTACTCGCATTC
GCTCCCGTTTTGCTACGCTCGGCGGTGCGGAGCTCGCATTGCCTGAGCGAAAAGATAAGGCCCGAGCAGCGAGCTTCGAT
GAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A660A202

Antitoxin

Source ID Structure
AlphaFold DB A0A660A1J7

References