Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4230738..4231392 Replicon chromosome
Accession NZ_CP044101
Organism Citrobacter werkmanii strain FDAARGOS_616

Toxin (Protein)


Gene name cptA Uniprot ID A0A2Z3X2B8
Locus tag FOB24_RS20815 Protein ID WP_038633481.1
Coordinates 4230738..4231145 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID R8WMJ6
Locus tag FOB24_RS20820 Protein ID WP_016154349.1
Coordinates 4231126..4231392 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOB24_RS20795 4226630..4228363 - 1734 WP_150345404.1 single-stranded-DNA-specific exonuclease RecJ -
FOB24_RS20800 4228369..4229082 - 714 WP_061382414.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
FOB24_RS20805 4229106..4230002 - 897 WP_038633475.1 site-specific tyrosine recombinase XerD -
FOB24_RS20810 4230116..4230637 + 522 WP_038633478.1 flavodoxin FldB -
FOB24_RS20815 4230738..4231145 - 408 WP_038633481.1 protein YgfX Toxin
FOB24_RS20820 4231126..4231392 - 267 WP_016154349.1 FAD assembly factor SdhE Antitoxin
FOB24_RS20830 4231649..4232629 + 981 WP_150345405.1 tRNA-modifying protein YgfZ -
FOB24_RS20835 4232721..4233380 - 660 WP_038633489.1 hemolysin III family protein -
FOB24_RS20840 4233544..4233855 - 312 WP_085048763.1 N(4)-acetylcytidine aminohydrolase -
FOB24_RS20845 4233908..4234636 + 729 WP_150345592.1 MurR/RpiR family transcriptional regulator -
FOB24_RS20850 4234757..4236190 + 1434 WP_038633498.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15944.81 Da        Isoelectric Point: 11.2845

>T140084 WP_038633481.1 NZ_CP044101:c4231145-4230738 [Citrobacter werkmanii]
VVQWQSDLRVSWRAQWLSLLVHGLVAVFILLMPWPLSYTPLWMVLLSLVVFDSVRSQRRINACQGEIRLLMDGRLRWQGQ
EWTIVSAPWMVKTGMMLRLRSDTGKRQHLWLAADSMDEAEWRDLRRLMLQQAKQG

Download         Length: 408 bp

>T140084 NZ_CP058907:c3843076-3842672 [Rhodopseudomonas palustris]
GTGAGGGCGTTCTTCGATACCGATATTTTGGTCTACTCCACGACGTCGGACCCGCGGCAAGCAACCGCCGCCGCTTGTCT
GGAGCAGGGCGGGTTTGCCAGCGTTCAGGTGCTCAACGAATTCGTCCACGTGGCGCGCCGCAAGCTGCGGCACGACTGGC
CGCAGATCGAGATGGCGCTCGAGCAGTTTCGCGCCGCGCTGGATGACGTGCGTCCGATCACTCTGGGCACTCACGTCGCT
GCAGTTGCGCTCGCGCGCGACCATCTGCTGTCCTTCTACGACGCGCTGATCGTCGCTGCCGCGCAGGAGGCTGGCTGCGA
TGTGCTGTACAGCGAAGACCTGCAGCACGGCCGTACCTTCGGTTCGTTGCGGGTCGAGAATCCATTTCTGGAAGGCTCGC
GATGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10557.10 Da        Isoelectric Point: 5.6375

>AT140084 WP_016154349.1 NZ_CP044101:c4231392-4231126 [Citrobacter werkmanii]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFIRLLECDDPDLFNWLMNHGKPADAQLEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT140084 NZ_CP058907:c3843303-3843073 [Rhodopseudomonas palustris]
ATGAAGGTCTCCAAATGGGGCAATAGCCTCGCCGTCAGACTGCCCAATGCGCTGGTCGACAGGCTCGAGCTGAAGGAGGG
CGACGAGCTGAATGTGGTCGATGTCGTCGAGCGGACGCTGGTGGTCGAGAAGGAGGACAGGCGGAAAGCAGCGGTGGAGC
GGCTTTCCAAGCTTAGGTGGACGCTGCCTCCCGATTACAAGTTCGATCGCGACGAGTCGAACGAGCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2Z3X2B8

Antitoxin

Source ID Structure
AlphaFold DB R8WMJ6

References