Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2704110..2704749 Replicon chromosome
Accession NZ_CP044101
Organism Citrobacter werkmanii strain FDAARGOS_616

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag FOB24_RS13675 Protein ID WP_150345057.1
Coordinates 2704573..2704749 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag FOB24_RS13670 Protein ID WP_087856629.1
Coordinates 2704110..2704526 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOB24_RS13650 2699155..2700099 - 945 WP_069324933.1 ABC transporter permease -
FOB24_RS13655 2700100..2701116 - 1017 WP_150345055.1 ABC transporter ATP-binding protein -
FOB24_RS13660 2701133..2702278 - 1146 WP_150345056.1 ABC transporter substrate-binding protein -
FOB24_RS13665 2702608..2704017 - 1410 WP_069324935.1 PLP-dependent aminotransferase family protein -
FOB24_RS13670 2704110..2704526 - 417 WP_087856629.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
FOB24_RS13675 2704573..2704749 - 177 WP_150345057.1 type II toxin-antitoxin system HicA family toxin Toxin
FOB24_RS13680 2705014..2706417 + 1404 WP_085048164.1 cytochrome ubiquinol oxidase subunit I -
FOB24_RS13685 2706417..2707427 + 1011 WP_087856574.1 cytochrome d ubiquinol oxidase subunit II -
FOB24_RS13690 2707427..2707552 + 126 WP_064507023.1 DUF2474 domain-containing protein -
FOB24_RS13695 2707742..2707972 + 231 WP_038640744.1 DUF2554 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(82-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6751.77 Da        Isoelectric Point: 11.6208

>T140075 WP_150345057.1 NZ_CP044101:c2704749-2704573 [Citrobacter werkmanii]
VKQSEFRRWLESQGVKVTNGSNHLKLRYQGRRSVVPRHPGDEIKEALRKAIQKQLGLQ

Download         Length: 177 bp

>T140075 NZ_CP058887:27108-27524 [Shigella flexneri]
ATGAAGAAAACCTGGATGCTCGACACTAACATCTGCTCGTTCATCATGCGCGAGCAGCCGGCAGCGGTGCTGAAGCGCCT
GGAGCAGGTGGTGCTGCGCGGTGATCGCATCGTGGTCTCGGCCGTGACGTATGCCGAGATGCGCTTCGGCGCCACCGGCC
CGAAGGCCTCGCCGCGCCATATTCAGCTGGTCGACGCGTTCTGCGCGCGCCTCGATGCCATCCTGCCCTGGGACCGGGCT
GCGGTGGACGCCACGACGGACATCCGGGTGGCGCTGCGCCTCGCCGGGACGCCGATCGGCCCGAACGACACCGCCATTGC
CGGACACGCCATCGCGGCGGGCGCCATCCTGGTGACAAACAATGTGAGAGAGTTTGAGCGGGTGCCGGGTCTGGTTCTGG
AAGACTGGGTTAAGTAA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15064.35 Da        Isoelectric Point: 4.5468

>AT140075 WP_087856629.1 NZ_CP044101:c2704526-2704110 [Citrobacter werkmanii]
MRYPVNLIPAVEGGFMVSFPDIPEALTQGETRHDALQAAQAALVTAFEFYFDDNEPIPLPSAVVAGADYVEIPLSVASKV
LLLNAFLESNITQQELANRIGRPKQEITRLFDLKHATKIDAVQIAARALGKELSVTML

Download         Length: 417 bp

>AT140075 NZ_CP058887:26881-27111 [Shigella flexneri]
ATGCGCACAGTTTCGATATTTAAAAACGGCAATAACCGCGCCATCCGTCTGCCCCGTGACCTGGATTTTGACGGCGTCAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGCTGG
ACAGGGCCGATCCAGACTTTATGGCGGAGCGTGAGGATGTGGTCAGCGACGAAGGACGCTTTGAGCCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References