Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacT-ataR/DUF1778(antitoxin)
Location 2609349..2610106 Replicon chromosome
Accession NZ_CP044101
Organism Citrobacter werkmanii strain FDAARGOS_616

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag FOB24_RS13230 Protein ID WP_085048216.1
Coordinates 2609349..2609831 (-) Length 161 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID -
Locus tag FOB24_RS13235 Protein ID WP_150345024.1
Coordinates 2609822..2610106 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOB24_RS13195 2604406..2605164 - 759 WP_085048227.1 trans-aconitate 2-methyltransferase -
FOB24_RS13200 2605274..2605798 + 525 WP_150345023.1 GNAT family N-acetyltransferase -
FOB24_RS13205 2605864..2606187 - 324 Protein_2406 helix-turn-helix domain-containing protein -
FOB24_RS13210 2606511..2607017 - 507 WP_004110859.1 polyketide cyclase -
FOB24_RS13215 2607151..2608059 - 909 WP_023464152.1 LysR family transcriptional regulator -
FOB24_RS13225 2609015..2609326 + 312 Protein_2409 helix-turn-helix transcriptional regulator -
FOB24_RS13230 2609349..2609831 - 483 WP_085048216.1 GNAT family N-acetyltransferase Toxin
FOB24_RS13235 2609822..2610106 - 285 WP_150345024.1 DUF1778 domain-containing protein Antitoxin
FOB24_RS13240 2610361..2610648 + 288 WP_150345025.1 VF530 family protein -
FOB24_RS13245 2610661..2612028 + 1368 WP_150345026.1 glycoside hydrolase family 10 protein -
FOB24_RS13250 2612066..2613337 - 1272 WP_150345027.1 type II toxin-antitoxin system HipA family toxin -
FOB24_RS13255 2613330..2613644 - 315 WP_150345028.1 helix-turn-helix transcriptional regulator -
FOB24_RS13260 2613806..2614444 - 639 WP_110498069.1 helix-turn-helix domain-containing protein -
FOB24_RS13265 2614656..2615054 + 399 WP_085048211.1 potassium channel family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(31-148)

Antitoxin

Vibrio phage ICP1, Orf50

(2-93)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17813.50 Da        Isoelectric Point: 7.7963

>T140074 WP_085048216.1 NZ_CP044101:c2609831-2609349 [Citrobacter werkmanii]
MEINVTTPVLLTEGHDLQPFDCGNDVLNDWLRRRAIKNQYLNASRTFVICLESTQRVVGYYSIATGSVSHADLGRSLRQN
MPDPVPVVLLGRLAVDVCTQGHSFGKWLLNDAVLRISNLADQVGIKAIMVHAIDGKARAFYEYFGFVQSPIAANTLFYKI

Download         Length: 483 bp

>T140074 NZ_CP058886:c4164638-4164465 [Shigella flexneri]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10997.51 Da        Isoelectric Point: 9.6543

>AT140074 WP_150345024.1 NZ_CP044101:c2610106-2609822 [Citrobacter werkmanii]
MQSSARKPTRDKQINIRATDEERAVIDYAASLVNKNRTDFIIEKAVHEAQNIILDQRVFVLDDARYQSFIEQLEAPVQNV
EGRQRLMNVKPKWK

Download         Length: 285 bp

>AT140074 NZ_CP058886:c4164962-4164666 [Shigella flexneri]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGATT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References