Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 346779..347395 Replicon chromosome
Accession NZ_CP044101
Organism Citrobacter werkmanii strain FDAARGOS_616

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag FOB24_RS02355 Protein ID WP_085049711.1
Coordinates 347021..347395 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A8E9YHE9
Locus tag FOB24_RS02350 Protein ID WP_001523745.1
Coordinates 346779..347021 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOB24_RS02315 342188..342787 + 600 WP_038635879.1 glucose-1-phosphatase -
FOB24_RS02320 342781..343653 + 873 WP_085049708.1 virulence factor BrkB family protein -
FOB24_RS02325 343650..344087 + 438 WP_003825289.1 D-tyrosyl-tRNA(Tyr) deacylase -
FOB24_RS02330 344132..345073 + 942 WP_032940213.1 fatty acid biosynthesis protein FabY -
FOB24_RS02335 345079..345367 - 289 Protein_314 type II toxin-antitoxin system RelE/ParE family toxin -
FOB24_RS02340 345360..345602 - 243 WP_150344466.1 type II toxin-antitoxin system ParD family antitoxin -
FOB24_RS02345 345667..346575 - 909 WP_150344467.1 alpha/beta hydrolase -
FOB24_RS02350 346779..347021 + 243 WP_001523745.1 ribbon-helix-helix domain-containing protein Antitoxin
FOB24_RS02355 347021..347395 + 375 WP_085049711.1 type II toxin-antitoxin system VapC family toxin Toxin
FOB24_RS02360 347432..348361 - 930 WP_006686145.1 formate dehydrogenase accessory protein FdhE -
FOB24_RS02365 348358..348993 - 636 WP_038635897.1 formate dehydrogenase cytochrome b556 subunit -
FOB24_RS02370 348990..349892 - 903 WP_003028691.1 formate dehydrogenase O subunit beta -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-115)

Antitoxin

Ribbon-helix-helix protein, CopG

(13-47)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13697.93 Da        Isoelectric Point: 8.5343

>T140070 WP_085049711.1 NZ_CP044101:347021-347395 [Citrobacter werkmanii]
MVKGAALFDTNILIDLFSGRSEAKLAIETWPPQNAISLITWMEVMVGAKKYHQEARTRIALGAFNIIGVSQDIAERSVNI
RQEYGMKLPDAIILATAQIHHLTLVTRNTKDFASISGVVTPYTL

Download         Length: 375 bp

>T140070 NZ_CP058886:3416995-3417213 [Shigella flexneri]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9437.77 Da        Isoelectric Point: 4.4463

>AT140070 WP_001523745.1 NZ_CP044101:346779-347021 [Citrobacter werkmanii]
MMAGMDMGRILLDLSDDVIKRLDDLKVQRNLPRAELLREAVEQYLERQDRAETTISKALGLWQGCEEDGVEYQRKLREEW

Download         Length: 243 bp

>AT140070 NZ_CP058886:3416595-3416969 [Shigella flexneri]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTAAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References