Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1129751..1130371 Replicon chromosome
Accession NZ_CP044098
Organism Citrobacter portucalensis strain FDAARGOS_617

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag FOB25_RS05425 Protein ID WP_002892050.1
Coordinates 1130153..1130371 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID R8WZW8
Locus tag FOB25_RS05420 Protein ID WP_003021733.1
Coordinates 1129751..1130125 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOB25_RS05410 1124897..1126090 + 1194 WP_032942549.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
FOB25_RS05415 1126113..1129262 + 3150 WP_008783964.1 multidrug efflux RND transporter permease subunit -
FOB25_RS05420 1129751..1130125 + 375 WP_003021733.1 Hha toxicity modulator TomB Antitoxin
FOB25_RS05425 1130153..1130371 + 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
FOB25_RS05430 1130553..1131104 + 552 WP_003835924.1 maltose O-acetyltransferase -
FOB25_RS05435 1131221..1131691 + 471 WP_020996574.1 YlaC family protein -
FOB25_RS05440 1131770..1131910 - 141 WP_005125190.1 type B 50S ribosomal protein L36 -
FOB25_RS05445 1131912..1132172 - 261 WP_008783961.1 type B 50S ribosomal protein L31 -
FOB25_RS05450 1132361..1133914 + 1554 WP_032942548.1 EAL domain-containing protein -
FOB25_RS05455 1133966..1134319 - 354 WP_008783959.1 DUF1428 family protein -
FOB25_RS05460 1134384..1135013 - 630 WP_032942547.1 membrane protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T140055 WP_002892050.1 NZ_CP044098:1130153-1130371 [Citrobacter portucalensis]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T140055 NZ_CP058882:37532-37684 [Escherichia coli]
ATGCCACAGCGAACGTTTTTAATGATGTTAATCGTCGTCTGTGTGACGATTCTGTGTTTTGTCTGGATGGTGAGGGATTC
GCTTTGCGGACTCCGGCTCCAGCAGGGAAACACAGTGCTTGTGGCAACGTTAGCCTACGAAGTTAAACGTTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14427.23 Da        Isoelectric Point: 5.5653

>AT140055 WP_003021733.1 NZ_CP044098:1129751-1130125 [Citrobacter portucalensis]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEQSNHGWVNDPTSATSLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT140055 NZ_CP058882:c37480-37420 [Escherichia coli]
GAGGCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB R8WZW8

References