Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3361199..3361853 Replicon chromosome
Accession NZ_CP044097
Organism Citrobacter koseri strain FDAARGOS_646

Toxin (Protein)


Gene name cptA Uniprot ID -
Locus tag FOB54_RS15915 Protein ID WP_114848306.1
Coordinates 3361199..3361606 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID -
Locus tag FOB54_RS15920 Protein ID WP_112001575.1
Coordinates 3361587..3361853 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOB54_RS15895 3357101..3358834 - 1734 WP_114848304.1 single-stranded-DNA-specific exonuclease RecJ -
FOB54_RS15900 3358840..3359553 - 714 WP_114848305.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
FOB54_RS15905 3359577..3360473 - 897 WP_012134998.1 site-specific tyrosine recombinase XerD -
FOB54_RS15910 3360577..3361101 + 525 WP_012134999.1 flavodoxin FldB -
FOB54_RS15915 3361199..3361606 - 408 WP_114848306.1 protein YgfX Toxin
FOB54_RS15920 3361587..3361853 - 267 WP_112001575.1 FAD assembly factor SdhE Antitoxin
FOB54_RS15925 3362110..3363090 + 981 WP_058668058.1 tRNA-modifying protein YgfZ -
FOB54_RS15930 3363242..3363901 - 660 WP_012135004.1 hemolysin III family protein -
FOB54_RS15935 3364063..3364374 - 312 WP_114848307.1 N(4)-acetylcytidine aminohydrolase -
FOB54_RS15940 3364427..3365155 + 729 WP_114848308.1 MurR/RpiR family transcriptional regulator -
FOB54_RS15945 3365276..3366709 + 1434 WP_012135007.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15916.82 Da        Isoelectric Point: 11.2845

>T140053 WP_114848306.1 NZ_CP044097:c3361606-3361199 [Citrobacter koseri]
VVLWQSDLRVSWRAQWLSLLIHGLVAALVLLMPWPLSYTPLWLILLSLVVFDCVRSQRRINTRQGEIKLLMDGRLRWQGQ
DWTIQGPPWMLKTGMMLRLRADSGKRQHLWLAADSMDDAEWRDLRRLMLQQVTQG

Download         Length: 408 bp

>T140053 NZ_CP058880:98414-98830 [Escherichia coli]
GTGAACAAGATCTATATGCTCGACACGAACATCTGCTCGTTCATCATGCGCGAGCAACCTGAAGCATTGCTTAAGCACCT
GGAGCAGTCGGTGCTGCGCGGTCACCGTATCGTGGTCTCGGCCATCACCTACTCCGAGATGCGCTTCGGTGCCACCGGTC
CGAAGGCCTCGCCACGCCACGTGCAACTGGTTGACGCGTTCTGTGAGAGGCTCGATGCCGTCCTGCCGTGGGACCGCGCC
GCGGTGGATGCGACCACGGAGATTAAGGTGGCACTGCGTCTCGCCGGCACGCCGATCGGTCCGAACGACACGGCGATAGC
CGGACACGCCATCGCTGCCTGTGCCATTCTGGTGACGAATAATGTGAGAGAGTTTGAGCGGGTACCGGGTCTTGTGCTGG
AAGACTGGGTAAGATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10475.95 Da        Isoelectric Point: 4.6872

>AT140053 WP_112001575.1 NZ_CP044097:c3361853-3361587 [Citrobacter koseri]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDNLSDEEKCIFVRLLECDDPDLFNWLMNHGKPGDAELEQMVQLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT140053 NZ_CP058880:98187-98417 [Escherichia coli]
ATGAGAACCGTATCCATTTTTAAAAATGGCAACAACCGTGCTATCCGCCTTCCACGCGATCTGGATTTTGAGGGGGTGAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGCCCCGTCCGGCCGACCTGGGGCTCATTCCTGGAGCTAG
AAAAGGCCGATCCGGACTTTATGACGGAGCGCGAGGACGTTGTCAGCGACGAAGGACGAGTTAACCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References