Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 1046284..1046896 Replicon chromosome
Accession NZ_CP044093
Organism Streptococcus pyogenes strain FDAARGOS_668

Toxin (Protein)


Gene name parE Uniprot ID Q1JJZ2
Locus tag FOB76_RS05480 Protein ID WP_002988077.1
Coordinates 1046284..1046619 (-) Length 112 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q5X9X9
Locus tag FOB76_RS05485 Protein ID WP_002988079.1
Coordinates 1046609..1046896 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOB76_RS05445 1041635..1042153 + 519 WP_002982682.1 NYN domain-containing protein -
FOB76_RS05450 1042250..1043110 + 861 WP_002982687.1 DegV family protein -
FOB76_RS05455 1043246..1043752 + 507 WP_002988070.1 hypothetical protein -
FOB76_RS05460 1043749..1043955 + 207 WP_002982695.1 helix-turn-helix transcriptional regulator -
FOB76_RS05465 1044173..1044619 + 447 WP_002982710.1 50S ribosomal protein L13 -
FOB76_RS05470 1044640..1045032 + 393 WP_002982716.1 30S ribosomal protein S9 -
FOB76_RS09475 1045152..1045301 - 150 WP_002982720.1 hypothetical protein -
FOB76_RS09480 1045337..1045699 - 363 WP_180373113.1 tyrosine-type recombinase/integrase -
FOB76_RS09485 1045662..1046132 - 471 WP_002988074.1 integrase -
FOB76_RS05480 1046284..1046619 - 336 WP_002988077.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FOB76_RS05485 1046609..1046896 - 288 WP_002988079.1 DNA-damage-inducible protein J Antitoxin
FOB76_RS05490 1047546..1048319 - 774 WP_002982738.1 DeoR/GlpR family DNA-binding transcription regulator -
FOB76_RS05495 1048765..1049193 + 429 WP_002982747.1 galactose-6-phosphate isomerase subunit LacA -
FOB76_RS05500 1049228..1049743 + 516 WP_002988082.1 galactose-6-phosphate isomerase subunit LacB -
FOB76_RS05505 1049789..1050718 + 930 WP_002988085.1 tagatose-6-phosphate kinase -
FOB76_RS05510 1050722..1051705 + 984 WP_002988088.1 tagatose-bisphosphate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-105)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 13117.83 Da        Isoelectric Point: 5.2144

>T140041 WP_002988077.1 NZ_CP044093:c1046619-1046284 [Streptococcus pyogenes]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIISDIEKLEVFPEVGFDADEKYGSKISHYHSTKGYTLSKD
YIVLYHIEGEENRVAIDYLLPTQSDYIKLFK

Download         Length: 336 bp

>T140041 NZ_CP058879:c2741798-2741696 [Escherichia coli]
GCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10934.56 Da        Isoelectric Point: 5.2318

>AT140041 WP_002988079.1 NZ_CP044093:c1046896-1046609 [Streptococcus pyogenes]
MTTVKKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRAELGL

Download         Length: 288 bp

>AT140041 NZ_CP058879:2741658-2741929 [Escherichia coli]
AAAGTCAGCGAAGGGAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCTCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGCGGTGGTCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A660A236

Antitoxin

Source ID Structure
AlphaFold DB A0A4U7GX94

References