Detailed information of TA system TA140036

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RelB(antitoxin)
• Location: 1544093..1544705
• Replicon: chromosome
• Accession: NZ_CP044090
• Organism: Streptococcus agalactiae strain FDAARGOS_670

Toxin (Protein)

• Gene name: parE
• Uniprot ID: Q8E1X3
• Locus tag: FOB78_RS08065
• Protein ID: WP_000384858.1
• Coordinates: 1544370..1544705 (+)
• Length: 112 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: Q8E1X2
• Locus tag: FOB78_RS08060
• Protein ID: WP_000255538.1
• Coordinates: 1544093..1544380 (+)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FOB78_RS08020	1539629..1540651	+	1023	WP_162841140.1	IS30 family transposase	-
FOB78_RS08030	1540888..1541169	-	282	WP_000052406.1	hypothetical protein	-
FOB78_RS08035	1541203..1541589	-	387	WP_000259069.1	hypothetical protein	-
FOB78_RS08040	1541574..1542254	-	681	WP_001865565.1	hypothetical protein	-
FOB78_RS08045	1542227..1542787	-	561	WP_001865562.1	hypothetical protein	-
FOB78_RS08050	1542787..1543194	-	408	WP_000749954.1	hypothetical protein	-
FOB78_RS08055	1543296..1543586	-	291	WP_000078283.1	WXG100 family type VII secretion target	-
FOB78_RS08060	1544093..1544380	+	288	WP_000255538.1	hypothetical protein	Antitoxin
FOB78_RS08065	1544370..1544705	+	336	WP_000384858.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FOB78_RS08070	1545010..1545480	-	471	WP_000130119.1	hypothetical protein	-
FOB78_RS08075	1545648..1546904	-	1257	WP_000122833.1	plasmid recombination protein	-
FOB78_RS08080	1547220..1547654	-	435	WP_001220479.1	hypothetical protein	-
FOB78_RS08085	1547690..1548565	-	876	WP_000770113.1	hypothetical protein	-
FOB78_RS08090	1548878..1549507	-	630	WP_000591149.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	1539629..1591999	52370
	-	flank	IS/Tn	-	-	1539629..1540651	1022

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (7-109)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 112 a.a.
• Molecular weight: 13264.04 Da
• Isoelectric Point: 5.2388

>T140036 WP_000384858.1 NZ_CP044090:1544370-1544705 [Streptococcus agalactiae]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQHKMEQIISDIEKLEVFPEVGFDADEKYGSKISKYHSTRGYTLSKD
YIVLYHIEEEENRVVIDYLLPTRSDYMKLFK

Nucleotide

• Length: 336 bp

>T140036 NZ_CP058879:c2014621-2014127 [Escherichia coli]
ATGATTCAGGCCCCCGAGCCACTCATGGCAAGGCATCAATTCACCTCTTTTTGCTCGGGAGTAGAAACGATGGATAACTG
GCTAAAGCAGAGAGCCCTAAAAAATCAGCTTGCCGGCGCATCACGTACATTTGTTAGCTGTGATACGTATAGCAACGTTT
TGGCATATTATTCGCTTGCTTCCAGCGCCGTTGAAACGTATGTCGCGACAGGACGATTTCGCCGAAATATGCCAGAACCG
ATCCCTGTTGTAGTACTTGGTCGTCTGGCAATAGATAAATCATTACAGGGTCAGGGCATCGGTCGTGCGATGGTCAGAGA
TGCCGGTCTACGAGTACTACAGGCGGCTGAAGTCATTGGTATTCGCGGAATGTTGGTCCATGCGTTATCAGACCAGGCCC
GTGAGTTTTATCTGCGAGTGGGGTTTGAACCATCGCCTGTCGATTCTATGATACTGATGGCAACATTGGCTGATTTGCAG
GAATGTCTTAAATAG

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10921.47 Da
• Isoelectric Point: 4.7271

>AT140036 WP_000255538.1 NZ_CP044090:1544093-1544380 [Streptococcus agalactiae]
MVTAEKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRSELGL

Nucleotide

• Length: 288 bp

>AT140036 NZ_CP058879:c2014911-2014618 [Escherichia coli]
ATGCCAGCAGCCAATAACATTCCAACCAGGCGCGAATCTTTAAATTTGCGCATAAAACCCGCAGAACGCGATCTTATTGA
CCGGGCCGCTAAAGCCCGAGGAAAAAATCGCACCGAATTTGTCCTTGAGGCCGCCAGAGCCGCAGCTGAAGAGGCGCTCA
TTGAGCAGAGAATTTTCAGGATCGATTCTGATGATTACCAGCTATTTTTGAATCGTCTGGATCAGCCCCCCGCGCCCAAT
GCTGCATTACGCAAAACCATGCAAACACCCGCGCCGTGGGAGCAAAAAAAATGA

Structures

Toxin

• AlphaFold DB: A0A0E1EF10

Antitoxin

• AlphaFold DB: A0A0E1EFF9