Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) omega-epsilon-zeta/zeta-epsilon
Location 1110899..1111442 Replicon chromosome
Accession NZ_CP044090
Organism Streptococcus agalactiae strain FDAARGOS_670

Toxin (Protein)


Gene name zeta Uniprot ID A0A1X9I2P4
Locus tag FOB78_RS05570 Protein ID WP_002943355.1
Coordinates 1110899..1111168 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name epsilon Uniprot ID Q9AL19
Locus tag FOB78_RS05575 Protein ID WP_002326825.1
Coordinates 1111170..1111442 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOB78_RS05520 1106005..1106295 - 291 WP_032458612.1 hypothetical protein -
FOB78_RS05525 1106345..1106734 - 390 WP_032458613.1 hypothetical protein -
FOB78_RS05530 1106731..1106958 - 228 WP_023370180.1 hypothetical protein -
FOB78_RS05535 1107012..1108088 - 1077 WP_027971256.1 toprim domain-containing protein -
FOB78_RS05540 1108128..1108758 - 631 Protein_1060 peptidylprolyl isomerase -
FOB78_RS05545 1108854..1109144 - 291 WP_024408865.1 membrane protein -
FOB78_RS05550 1109158..1109457 - 300 WP_024408864.1 hypothetical protein -
FOB78_RS05555 1109528..1110487 - 960 Protein_1063 hypothetical protein -
FOB78_RS05560 1110454..1110801 - 348 Protein_1064 DUF4368 domain-containing protein -
FOB78_RS05570 1110899..1111168 - 270 WP_002943355.1 zeta toxin family protein Toxin
FOB78_RS05575 1111170..1111442 - 273 WP_002326825.1 antitoxin Antitoxin
FOB78_RS05580 1111460..1111669 - 210 WP_000527318.1 peptide-binding protein -
FOB78_RS05585 1111767..1112663 - 897 WP_002326827.1 ParA family protein -
FOB78_RS05590 1112766..1113026 - 261 Protein_1069 topoisomerase DNA-binding C4 zinc finger domain-containing protein -
FOB78_RS05600 1113196..1113933 - 738 WP_150352941.1 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(B) -
FOB78_RS05605 1114058..1114141 - 84 WP_001814874.1 23S rRNA methyltransferase attenuation leader peptide -
FOB78_RS05615 1114269..1115291 - 1023 WP_162841140.1 IS30 family transposase -
FOB78_RS05620 1115367..1115606 - 240 WP_150352943.1 peptide-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element erm(B) / tet(O) cylK / cylJ / cylI / cylF / cylE / cylB / cylA / cylZ / acpC / cylG / cylD / cylX 981310..1216855 235545
- flank IS/Tn erm(B) - 1113196..1115291 2095


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(27-75)

Antitoxin

Bacterial epsilon antitoxin

(2-90)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 9999.08 Da        Isoelectric Point: 8.7696

>T140034 WP_002943355.1 NZ_CP044090:c1111168-1110899 [Streptococcus agalactiae]
MANITDFTEKQFEDRLEKNVERLTKNRLAVESPTAFLLGGQPGSGKTSLRSAISEETQGNVVIIDNDTFKQQHPRSTFAN
VNKRNNFNS

Download         Length: 270 bp

>T140034 NZ_CP058879:964232-964639 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATCTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATCCACGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGCATTAATGCTCGCCAGGGGGAAATTCGCCTGTTGATGGACGGGCGTTTGCGCTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGACAGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATATTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10720.17 Da        Isoelectric Point: 4.4865

>AT140034 WP_002326825.1 NZ_CP044090:c1111442-1111170 [Streptococcus agalactiae]
MAVTYEKTFEIEIINELSASVYNRVLNYVLNHELDTKNTRLLEVNLLNQLEVAQEVDLFQQPFEELQAIHEYWRSMNQYS
KQILTKEKVA

Download         Length: 273 bp

>AT140034 NZ_CP058879:963985-964251 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAGTGTGACGATCCCGATC
TGTTTAACTGGCTGATGAACCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1X9I2P4

Antitoxin

Source ID Structure
AlphaFold DB A0A0M2AF93

References