Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | omega-epsilon-zeta/zeta-epsilon |
Location | 1110899..1111442 | Replicon | chromosome |
Accession | NZ_CP044090 | ||
Organism | Streptococcus agalactiae strain FDAARGOS_670 |
Toxin (Protein)
Gene name | zeta | Uniprot ID | A0A1X9I2P4 |
Locus tag | FOB78_RS05570 | Protein ID | WP_002943355.1 |
Coordinates | 1110899..1111168 (-) | Length | 90 a.a. |
Antitoxin (Protein)
Gene name | epsilon | Uniprot ID | Q9AL19 |
Locus tag | FOB78_RS05575 | Protein ID | WP_002326825.1 |
Coordinates | 1111170..1111442 (-) | Length | 91 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
FOB78_RS05520 | 1106005..1106295 | - | 291 | WP_032458612.1 | hypothetical protein | - |
FOB78_RS05525 | 1106345..1106734 | - | 390 | WP_032458613.1 | hypothetical protein | - |
FOB78_RS05530 | 1106731..1106958 | - | 228 | WP_023370180.1 | hypothetical protein | - |
FOB78_RS05535 | 1107012..1108088 | - | 1077 | WP_027971256.1 | toprim domain-containing protein | - |
FOB78_RS05540 | 1108128..1108758 | - | 631 | Protein_1060 | peptidylprolyl isomerase | - |
FOB78_RS05545 | 1108854..1109144 | - | 291 | WP_024408865.1 | membrane protein | - |
FOB78_RS05550 | 1109158..1109457 | - | 300 | WP_024408864.1 | hypothetical protein | - |
FOB78_RS05555 | 1109528..1110487 | - | 960 | Protein_1063 | hypothetical protein | - |
FOB78_RS05560 | 1110454..1110801 | - | 348 | Protein_1064 | DUF4368 domain-containing protein | - |
FOB78_RS05570 | 1110899..1111168 | - | 270 | WP_002943355.1 | zeta toxin family protein | Toxin |
FOB78_RS05575 | 1111170..1111442 | - | 273 | WP_002326825.1 | antitoxin | Antitoxin |
FOB78_RS05580 | 1111460..1111669 | - | 210 | WP_000527318.1 | peptide-binding protein | - |
FOB78_RS05585 | 1111767..1112663 | - | 897 | WP_002326827.1 | ParA family protein | - |
FOB78_RS05590 | 1112766..1113026 | - | 261 | Protein_1069 | topoisomerase DNA-binding C4 zinc finger domain-containing protein | - |
FOB78_RS05600 | 1113196..1113933 | - | 738 | WP_150352941.1 | 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(B) | - |
FOB78_RS05605 | 1114058..1114141 | - | 84 | WP_001814874.1 | 23S rRNA methyltransferase attenuation leader peptide | - |
FOB78_RS05615 | 1114269..1115291 | - | 1023 | WP_162841140.1 | IS30 family transposase | - |
FOB78_RS05620 | 1115367..1115606 | - | 240 | WP_150352943.1 | peptide-binding protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Integrative and Conjugative Element | erm(B) / tet(O) | cylK / cylJ / cylI / cylF / cylE / cylB / cylA / cylZ / acpC / cylG / cylD / cylX | 981310..1216855 | 235545 | |
- | flank | IS/Tn | erm(B) | - | 1113196..1115291 | 2095 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 90 a.a. Molecular weight: 9999.08 Da Isoelectric Point: 8.7696
>T140034 WP_002943355.1 NZ_CP044090:c1111168-1110899 [Streptococcus agalactiae]
MANITDFTEKQFEDRLEKNVERLTKNRLAVESPTAFLLGGQPGSGKTSLRSAISEETQGNVVIIDNDTFKQQHPRSTFAN
VNKRNNFNS
MANITDFTEKQFEDRLEKNVERLTKNRLAVESPTAFLLGGQPGSGKTSLRSAISEETQGNVVIIDNDTFKQQHPRSTFAN
VNKRNNFNS
Download Length: 270 bp
>T140034 NZ_CP058879:964232-964639 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATCTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATCCACGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGCATTAATGCTCGCCAGGGGGAAATTCGCCTGTTGATGGACGGGCGTTTGCGCTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGACAGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATATTGTTGCAACAAGAGACGC
AAAGATAA
GTGGTCCTGTGGCAATCTGATCTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATCCACGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGCATTAATGCTCGCCAGGGGGAAATTCGCCTGTTGATGGACGGGCGTTTGCGCTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGACAGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATATTGTTGCAACAAGAGACGC
AAAGATAA
Antitoxin
Download Length: 91 a.a. Molecular weight: 10720.17 Da Isoelectric Point: 4.4865
>AT140034 WP_002326825.1 NZ_CP044090:c1111442-1111170 [Streptococcus agalactiae]
MAVTYEKTFEIEIINELSASVYNRVLNYVLNHELDTKNTRLLEVNLLNQLEVAQEVDLFQQPFEELQAIHEYWRSMNQYS
KQILTKEKVA
MAVTYEKTFEIEIINELSASVYNRVLNYVLNHELDTKNTRLLEVNLLNQLEVAQEVDLFQQPFEELQAIHEYWRSMNQYS
KQILTKEKVA
Download Length: 273 bp
>AT140034 NZ_CP058879:963985-964251 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAGTGTGACGATCCCGATC
TGTTTAACTGGCTGATGAACCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAGTGTGACGATCCCGATC
TGTTTAACTGGCTGATGAACCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A1X9I2P4 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0M2AF93 |