Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | sezT-pezT/zeta-couple_hipB |
| Location | 1104671..1105935 | Replicon | chromosome |
| Accession | NZ_CP044090 | ||
| Organism | Streptococcus agalactiae strain FDAARGOS_670 | ||
Toxin (Protein)
| Gene name | sezT | Uniprot ID | - |
| Locus tag | FOB78_RS05510 | Protein ID | WP_032458611.1 |
| Coordinates | 1104671..1105459 (-) | Length | 263 a.a. |
Antitoxin (Protein)
| Gene name | pezT | Uniprot ID | A0A0Z8GXZ9 |
| Locus tag | FOB78_RS05515 | Protein ID | WP_024415699.1 |
| Coordinates | 1105459..1105935 (-) | Length | 159 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| FOB78_RS05485 | 1099736..1100101 | - | 366 | WP_000431640.1 | plasmid mobilization relaxosome protein MobC | - |
| FOB78_RS05490 | 1100104..1100466 | - | 363 | WP_000140674.1 | hypothetical protein | - |
| FOB78_RS05495 | 1100804..1101396 | - | 593 | Protein_1051 | hypothetical protein | - |
| FOB78_RS05500 | 1101393..1102934 | - | 1542 | WP_024383488.1 | ATP-dependent helicase | - |
| FOB78_RS05505 | 1102927..1104681 | - | 1755 | WP_032458610.1 | AAA family ATPase | - |
| FOB78_RS05510 | 1104671..1105459 | - | 789 | WP_032458611.1 | zeta toxin family protein | Toxin |
| FOB78_RS05515 | 1105459..1105935 | - | 477 | WP_024415699.1 | helix-turn-helix domain-containing protein | Antitoxin |
| FOB78_RS05520 | 1106005..1106295 | - | 291 | WP_032458612.1 | hypothetical protein | - |
| FOB78_RS05525 | 1106345..1106734 | - | 390 | WP_032458613.1 | hypothetical protein | - |
| FOB78_RS05530 | 1106731..1106958 | - | 228 | WP_023370180.1 | hypothetical protein | - |
| FOB78_RS05535 | 1107012..1108088 | - | 1077 | WP_027971256.1 | toprim domain-containing protein | - |
| FOB78_RS05540 | 1108128..1108758 | - | 631 | Protein_1060 | peptidylprolyl isomerase | - |
| FOB78_RS05545 | 1108854..1109144 | - | 291 | WP_024408865.1 | membrane protein | - |
| FOB78_RS05550 | 1109158..1109457 | - | 300 | WP_024408864.1 | hypothetical protein | - |
| FOB78_RS05555 | 1109528..1110487 | - | 960 | Protein_1063 | hypothetical protein | - |
| FOB78_RS05560 | 1110454..1110801 | - | 348 | Protein_1064 | DUF4368 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | erm(B) / tet(O) | cylK / cylJ / cylI / cylF / cylE / cylB / cylA / cylZ / acpC / cylG / cylD / cylX | 981310..1216855 | 235545 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 263 a.a. Molecular weight: 29720.70 Da Isoelectric Point: 5.7391
>T140033 WP_032458611.1 NZ_CP044090:c1105459-1104671 [Streptococcus agalactiae]
MRLEEFSEVEFQKALQRTIRALTRGKTIPDQPKAILLGGQSGAGKTTIHRIKQKEFQGNIIIIDGDSYRSQHPNYLALQE
KYGKDSVDYTKGFAGKMVEQLVDELSTQGYHLLIEGTLRTTQVPRQTAQLLSSKGYQVSLAVIGTKPELSYLSTLIRYEE
LYAIDPTQARATPKEHHDGIVENLVDNLRELESENLFDQIQIYQRDRTCIYDSETAEGSAAEVLQECLFGKCSKVEEEMM
KLGRERLVKLNNKNLLESNYGI
MRLEEFSEVEFQKALQRTIRALTRGKTIPDQPKAILLGGQSGAGKTTIHRIKQKEFQGNIIIIDGDSYRSQHPNYLALQE
KYGKDSVDYTKGFAGKMVEQLVDELSTQGYHLLIEGTLRTTQVPRQTAQLLSSKGYQVSLAVIGTKPELSYLSTLIRYEE
LYAIDPTQARATPKEHHDGIVENLVDNLRELESENLFDQIQIYQRDRTCIYDSETAEGSAAEVLQECLFGKCSKVEEEMM
KLGRERLVKLNNKNLLESNYGI
Download Length: 789 bp
>T140033 NZ_CP058879:c872613-872239 [Escherichia coli]
ATGAACACATTACCCGACACACACGTACGGAAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTGTC
CCGACTACTGGGCCAGCATTACGGCCTTACACTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGACGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACTTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGCATCCGGAGAAACGATGA
ATGAACACATTACCCGACACACACGTACGGAAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTGTC
CCGACTACTGGGCCAGCATTACGGCCTTACACTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGACGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACTTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGCATCCGGAGAAACGATGA
Antitoxin
Download Length: 159 a.a. Molecular weight: 18243.69 Da Isoelectric Point: 4.4582
>AT140033 WP_024415699.1 NZ_CP044090:c1105935-1105459 [Streptococcus agalactiae]
MIGDNIKSLRRTHDLTQPEFAKMVGISRNSLSRYENGTSTVSTELIDRICQKFNVSYVDIVGEDKMLTPVEDYQLTLKIE
VIKERGAAILSQLYRYQDSQGIAFDDETNPWILMSDDLAELINTKIYLVDTFDEIERYNGYLDGIERMLDMVHHRVVA
MIGDNIKSLRRTHDLTQPEFAKMVGISRNSLSRYENGTSTVSTELIDRICQKFNVSYVDIVGEDKMLTPVEDYQLTLKIE
VIKERGAAILSQLYRYQDSQGIAFDDETNPWILMSDDLAELINTKIYLVDTFDEIERYNGYLDGIERMLDMVHHRVVA
Download Length: 477 bp
>AT140033 NZ_CP058879:c873071-872703 [Escherichia coli]
GTGTCAGACACATTCTCCGGGACAACTCATCCCGATGACAATCACGACCGTCCCTGGTGGGGACTACCCAGCACCGTGAC
GCCCTGTTTCGGGGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGATGCGGATGCGAACCATCTGGACCAAGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGTTCACCAGCAGT
GAACTGAATCCCCACCGTCAGAATACCGTCACGCTGTATGCTAAAGGGCTGACCTGCCATGCGGACACCCTCGGCAGCTG
TGGTTACGTTTATCTTGCTGTTTATCCGACGCCCGAAACGAAACAGTAA
GTGTCAGACACATTCTCCGGGACAACTCATCCCGATGACAATCACGACCGTCCCTGGTGGGGACTACCCAGCACCGTGAC
GCCCTGTTTCGGGGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGATGCGGATGCGAACCATCTGGACCAAGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGTTCACCAGCAGT
GAACTGAATCCCCACCGTCAGAATACCGTCACGCTGTATGCTAAAGGGCTGACCTGCCATGCGGACACCCTCGGCAGCTG
TGGTTACGTTTATCTTGCTGTTTATCCGACGCCCGAAACGAAACAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|