Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 4806017..4806611 Replicon chromosome
Accession NZ_CP044089
Organism Bordetella bronchiseptica strain FDAARGOS_634

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag FOB42_RS22610 Protein ID WP_003819882.1
Coordinates 4806017..4806199 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag FOB42_RS22615 Protein ID WP_003819880.1
Coordinates 4806222..4806611 (+) Length 130 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOB42_RS22590 4801020..4801760 + 741 WP_050457493.1 carbonic anhydrase -
FOB42_RS22595 4801772..4803127 - 1356 WP_150349136.1 cytochrome c -
FOB42_RS22600 4803138..4804907 - 1770 WP_004568200.1 GMC family oxidoreductase -
FOB42_RS22605 4804911..4805609 - 699 WP_003809653.1 gluconate 2-dehydrogenase subunit 3 family protein -
FOB42_RS22610 4806017..4806199 + 183 WP_003819882.1 type II toxin-antitoxin system HicA family toxin Toxin
FOB42_RS22615 4806222..4806611 + 390 WP_003819880.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
FOB42_RS22625 4806878..4807654 - 777 WP_033448479.1 phosphate ABC transporter ATP-binding protein PstB -
FOB42_RS22630 4807699..4808556 - 858 WP_003809638.1 phosphate ABC transporter permease PstA -
FOB42_RS22635 4808578..4809594 - 1017 WP_003809636.1 phosphate ABC transporter permease subunit PstC -
FOB42_RS22640 4809729..4810769 - 1041 WP_003809635.1 phosphate ABC transporter substrate-binding protein PstS -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-122)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6822.91 Da        Isoelectric Point: 11.4375

>T140031 WP_003819882.1 NZ_CP044089:4806017-4806199 [Bordetella bronchiseptica]
MNSADLIKRLKADGWYRVHTVGSHHQYKHPTKPGKVTVPHPRKDLPTATQRSILKQAGLR

Download         Length: 183 bp

>T140031 NZ_CP058879:c678921-678457 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAGACAGAAGAAACCCATTGA

Antitoxin


Download         Length: 130 a.a.        Molecular weight: 14300.00 Da        Isoelectric Point: 4.3864

>AT140031 WP_003819880.1 NZ_CP044089:4806222-4806611 [Bordetella bronchiseptica]
MLYPIHVSKDEGSAYGAVFPDFPGCFAAADELQDLPRAAQEAVEAHFYGETERIPAPSAPEAWANDEDYRGGYWMMVDID
LSKVSTKAVRLNISLPENLVHRIDEEAKARRLSRSAFLAMAAEHEMADA

Download         Length: 390 bp

>AT140031 NZ_CP058879:c679256-678921 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCTGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References