Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 2734147..2734782 Replicon chromosome
Accession NZ_CP044089
Organism Bordetella bronchiseptica strain FDAARGOS_634

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag FOB42_RS12825 Protein ID WP_150348967.1
Coordinates 2734600..2734782 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID Q7VZH1
Locus tag FOB42_RS12820 Protein ID WP_004566317.1
Coordinates 2734147..2734539 (-) Length 131 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOB42_RS12795 2729801..2730223 - 423 WP_004566320.1 OB-fold domain-containing protein -
FOB42_RS12800 2730227..2731399 - 1173 WP_004566319.1 thiolase domain-containing protein -
FOB42_RS12805 2731466..2731825 - 360 WP_010930087.1 hypothetical protein -
FOB42_RS12810 2731860..2732834 - 975 WP_003821495.1 tripartite tricarboxylate transporter substrate binding protein -
FOB42_RS12815 2732959..2733870 + 912 WP_003821497.1 LysR family transcriptional regulator -
FOB42_RS12820 2734147..2734539 - 393 WP_004566317.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
FOB42_RS12825 2734600..2734782 - 183 WP_150348967.1 type II toxin-antitoxin system HicA family toxin Toxin
FOB42_RS12840 2735557..2736741 - 1185 WP_004566278.1 MFS transporter -
FOB42_RS12845 2736957..2737634 - 678 WP_003821504.1 HAD-IA family hydrolase -
FOB42_RS12850 2737631..2738356 - 726 WP_033448326.1 bifunctional 2-polyprenyl-6-hydroxyphenol methylase/3-demethylubiquinol 3-O-methyltransferase UbiG -
FOB42_RS12855 2738482..2739063 - 582 WP_003813377.1 OmpA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6635.79 Da        Isoelectric Point: 11.1475

>T140028 WP_150348967.1 NZ_CP044089:c2734782-2734600 [Bordetella bronchiseptica]
MDSKELIKQLERSGWTLRGVKASHHVFTHPDRPGHISVPRPKKDLGIGLLNSILKAAGLK

Download         Length: 183 bp

>T140028 NZ_CP058879:267122-267229 [Escherichia coli]
ATGACGCTCGCAGAACTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGCATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 131 a.a.        Molecular weight: 14057.83 Da        Isoelectric Point: 4.2876

>AT140028 WP_004566317.1 NZ_CP044089:c2734539-2734147 [Bordetella bronchiseptica]
VKYPIAIEPGSDTRAWGVVVPDLPGCFSAADEGIDQAIENAKEAIELWIETAIDSGAPIPPATSIANHQANPEFANWIWA
IADVDPAVLDETVERVNITIPRRILKRLDDRARAAGESRSSYIAHLAMTA

Download         Length: 393 bp

>AT140028 NZ_CP058879:c267073-267010 [Escherichia coli]
GTCTAGGTTCAAGATTAGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB Q7VZH1

References