Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4989608..4990265 Replicon chromosome
Accession NZ_CP044083
Organism Klebsiella aerogenes strain FDAARGOS_641

Toxin (Protein)


Gene name cptA Uniprot ID A0A0H3FM52
Locus tag FOB49_RS24390 Protein ID WP_015369792.1
Coordinates 4989855..4990265 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A0H3FJK6
Locus tag FOB49_RS24385 Protein ID WP_015369791.1
Coordinates 4989608..4989874 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOB49_RS24360 4984835..4986268 - 1434 WP_015369787.1 6-phospho-beta-glucosidase BglA -
FOB49_RS24365 4986382..4987116 - 735 WP_015703423.1 MurR/RpiR family transcriptional regulator -
FOB49_RS24370 4987167..4987478 + 312 WP_015703422.1 N(4)-acetylcytidine aminohydrolase -
FOB49_RS24375 4987643..4988302 + 660 WP_008806429.1 hemolysin III family protein -
FOB49_RS24380 4988401..4989384 - 984 WP_015703421.1 tRNA-modifying protein YgfZ -
FOB49_RS24385 4989608..4989874 + 267 WP_015369791.1 FAD assembly factor SdhE Antitoxin
FOB49_RS24390 4989855..4990265 + 411 WP_015369792.1 protein YgfX Toxin
FOB49_RS24395 4990273..4990794 - 522 WP_015369793.1 flavodoxin FldB -
FOB49_RS24400 4990895..4991791 + 897 WP_015703420.1 site-specific tyrosine recombinase XerD -
FOB49_RS24405 4991814..4992527 + 714 WP_015369795.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
FOB49_RS24410 4992533..4994266 + 1734 WP_015369796.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 15887.69 Da        Isoelectric Point: 10.0200

>T140024 WP_015369792.1 NZ_CP044083:4989855-4990265 [Klebsiella aerogenes]
VVLWQSDLRISWRSQWFSLLLHGVVAAIVLLMPWPLSYTPIWLLLLSLVVFDCVRSQRRIHACQGEIKLLIDSRLRWQKT
EWDIVGTPWVISSGMLLRLKHAETGRSQHLWVAADSMDAGEWRDLRRLVLQKPAHD

Download         Length: 411 bp

>T140024 NZ_CP058876:73162-73314 [Escherichia coli]
ATGCCACAGCGAACGTTTTTAATGATGTTAATCGTCATCTGTGTGACGATTCTGTGTTTTGTCTGGATGGTGAGGGATTC
GCTTTGCGGACTCCGGCTCCAGCAGGGAAACACAGTGCTTGTGGCAACGTTAGCCTACGAAGTTAAACGTTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10579.09 Da        Isoelectric Point: 5.6963

>AT140024 WP_015369791.1 NZ_CP044083:4989608-4989874 [Klebsiella aerogenes]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDDDKRLFIRLLENDDPDLFNWLMNHGKPADAQLQRMINLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT140024 NZ_CP058876:c73107-73050 [Escherichia coli]
GCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3FM52

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3FJK6

References