Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yfjZ-ypjF/CbtA-CbeA
Location 4204465..4205132 Replicon chromosome
Accession NZ_CP044083
Organism Klebsiella aerogenes strain FDAARGOS_641

Toxin (Protein)


Gene name ypjF Uniprot ID A0A0H3FNF1
Locus tag FOB49_RS20500 Protein ID WP_015703842.1
Coordinates 4204465..4204785 (-) Length 107 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID A0A0H3FLG0
Locus tag FOB49_RS20505 Protein ID WP_015703841.1
Coordinates 4204806..4205132 (-) Length 109 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOB49_RS20475 4200276..4201472 + 1197 WP_015703847.1 hypothetical protein -
FOB49_RS20480 4201757..4202794 - 1038 WP_015703846.1 virulence RhuM family protein -
FOB49_RS20485 4203018..4203305 - 288 WP_015703845.1 SymE family type I addiction module toxin -
FOB49_RS20490 4203442..4203636 + 195 WP_015703844.1 toxin-antitoxin system HicB family antitoxin -
FOB49_RS20495 4203652..4204218 - 567 WP_015703843.1 hypothetical protein -
FOB49_RS20500 4204465..4204785 - 321 WP_015703842.1 TA system toxin CbtA family protein Toxin
FOB49_RS20505 4204806..4205132 - 327 WP_015703841.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
FOB49_RS20510 4205145..4205615 - 471 WP_015703840.1 DNA repair protein RadC -
FOB49_RS20515 4205683..4206504 - 822 WP_015703839.1 DUF945 domain-containing protein -
FOB49_RS20520 4206597..4207607 - 1011 WP_015703838.1 hypothetical protein -
FOB49_RS20525 4207669..4208358 - 690 WP_015703837.1 WYL domain-containing protein -
FOB49_RS20530 4208550..4209443 - 894 WP_015703836.1 50S ribosome-binding GTPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-98)

Antitoxin

Antitoxin CbeA

(7-107)


Sequences

Toxin        


Download         Length: 107 a.a.        Molecular weight: 12106.95 Da        Isoelectric Point: 5.5873

>T140022 WP_015703842.1 NZ_CP044083:c4204785-4204465 [Klebsiella aerogenes]
MNTQPATTPQAAKPCLSPLAVWKMLLTILLDQHYGLTLNDTPFSDETVIQKHIEAGITLADAINFLVERYELVRIDQKGF
SVQDQEPWLTSMDVHRARFKLNVERL

Download         Length: 321 bp

>T140022 NZ_CP058875:137999-138148 [Escherichia coli]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAGCTGAATATTCACAGAGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 109 a.a.        Molecular weight: 12268.98 Da        Isoelectric Point: 6.2003

>AT140022 WP_015703841.1 NZ_CP044083:c4205132-4204806 [Klebsiella aerogenes]
MSLIPAHEWGLQREIVPRFGARLVQEGNRLHYLADRASLMGNFSDTECFKLNDAFPHFISQMESMLTTGELIPCHQHCVT
LYHNGFTCEADTLGSCGYVYIAVYPTQR

Download         Length: 327 bp

>AT140022 NZ_CP058875:c137955-137894 [Escherichia coli]
TTAAGGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3FNF1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3FLG0

References