Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 2814357..2814976 Replicon chromosome
Accession NZ_CP044083
Organism Klebsiella aerogenes strain FDAARGOS_641

Toxin (Protein)


Gene name Hha Uniprot ID A0A0H3FXE2
Locus tag FOB49_RS13750 Protein ID WP_015367918.1
Coordinates 2814758..2814976 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A0H3FPM3
Locus tag FOB49_RS13745 Protein ID WP_015367917.1
Coordinates 2814357..2814731 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOB49_RS13735 2809517..2810716 + 1200 WP_020079451.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
FOB49_RS13740 2810739..2813885 + 3147 WP_015704610.1 multidrug efflux RND transporter permease subunit -
FOB49_RS13745 2814357..2814731 + 375 WP_015367917.1 Hha toxicity modulator TomB Antitoxin
FOB49_RS13750 2814758..2814976 + 219 WP_015367918.1 hemolysin expression modulator Hha Toxin
FOB49_RS13755 2815108..2815671 + 564 WP_015704609.1 maltose O-acetyltransferase -
FOB49_RS13765 2815797..2816261 + 465 WP_015367920.1 YlaC family protein -
FOB49_RS13770 2816236..2817690 - 1455 WP_015704608.1 PLP-dependent aminotransferase family protein -
FOB49_RS13775 2817793..2818503 + 711 WP_015704607.1 GNAT family N-acetyltransferase -
FOB49_RS13780 2818500..2818640 - 141 WP_003859006.1 type B 50S ribosomal protein L36 -
FOB49_RS13785 2818643..2818903 - 261 WP_015367923.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8569.96 Da        Isoelectric Point: 9.4828

>T140021 WP_015367918.1 NZ_CP044083:2814758-2814976 [Klebsiella aerogenes]
MSGKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T140021 NZ_CP058875:c130010-129612 [Escherichia coli]
ATGCTGAAGTTTATGCTCGATACCAACATCTGCATTTTCACGATGAAGAACAAACCCGCCAGCGTCAGGGAGCGTTTTAA
CCTGAACCAGGGGAGAATGTGTATCAGTTCGGTCACCCTGATGGAGCTGATATATGGTGCAGAAAAAAGCCAGATGCCTG
AACGTAATCTCGCTGTGATCGAGGGATTTGTTTCCCGCATTGATGTTCTGGATTACGACGCTGCCGCAGCCACACACAGC
GGCCAGATAAGAGCAGAACTTGCCCGTCAGGGACGCCCTGTCGGGCCATTTGATCAAATGATCGCAGGTCATGCCCGCAG
TCGGGGACTGATTATTGTGACTAATAACACCCGGGAATTTGAACGTGTGGACGGTCTGAGAATTGAAGACTGGAGCTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14464.21 Da        Isoelectric Point: 4.9045

>AT140021 WP_015367917.1 NZ_CP044083:2814357-2814731 [Klebsiella aerogenes]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNRGWVNDPTSAVNLQLNELIEHIATYALNYKIKYAEDNKLISQLDEYL
DDTFMLFSSYGINTSDLQKWRKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT140021 NZ_CP058875:c130237-130010 [Escherichia coli]
ATGGAAACCACCGTATTTTTCAGCAACCGCAGCCAGGCGGTCAGACTGCCAAAAGCGGTTGCATTGCCGGAAAACGTAAA
ACGCGTTGAAGTGATTGCTGTCGGACGAACCAGAATCATTACGCCAGCCGGAGAGACATGGGACGAATGGTTCGACGGAC
ACAACGTCAGCGCCGATTTTATGGATAACAGGGAACAGCCCGGCATGCAGGAAAGGGAGTCATTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3FXE2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3FPM3

References