Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 2814357..2814976 Replicon chromosome
Accession NZ_CP044083
Organism Klebsiella aerogenes strain FDAARGOS_641

Toxin (Protein)


Gene name Hha Uniprot ID A0A0H3FXE2
Locus tag FOB49_RS13750 Protein ID WP_015367918.1
Coordinates 2814758..2814976 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A0H3FPM3
Locus tag FOB49_RS13745 Protein ID WP_015367917.1
Coordinates 2814357..2814731 (+) Length 125 a.a.

Genomic Context

FOB49_RS13735FOB49_RS13740FOB49_RS13745FOB49_RS13750FOB49_RS13755FOB49_RS13765FOB49_RS13775FOB49_RS13770FOB49_RS13780FOB49_RS13785
Location: 2809517..2810716 (1200 bp)
Type: Others
Protein ID: WP_020079451.1
Location: 2810739..2813885 (3147 bp)
Type: Others
Protein ID: WP_015704610.1
Location: 2814357..2814731 (375 bp)
Type: Antitoxin
Protein ID: WP_015367917.1
Location: 2814758..2814976 (219 bp)
Type: Toxin
Protein ID: WP_015367918.1
Location: 2815108..2815671 (564 bp)
Type: Others
Protein ID: WP_015704609.1
Location: 2815797..2816261 (465 bp)
Type: Others
Protein ID: WP_015367920.1
Location: 2817793..2818503 (711 bp)
Type: Others
Protein ID: WP_015704607.1
Location: 2816236..2817690 (1455 bp)
Type: Others
Protein ID: WP_015704608.1
Location: 2818500..2818640 (141 bp)
Type: Others
Protein ID: WP_003859006.1
Location: 2818643..2818903 (261 bp)
Type: Others
Protein ID: WP_015367923.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
FOB49_RS137352809517..2810716+1200WP_020079451.1multidrug efflux RND transporter periplasmic adaptor subunit AcrA-
FOB49_RS137402810739..2813885+3147WP_015704610.1multidrug efflux RND transporter permease subunit-
FOB49_RS137452814357..2814731+375WP_015367917.1Hha toxicity modulator TomBAntitoxin
FOB49_RS137502814758..2814976+219WP_015367918.1hemolysin expression modulator HhaToxin
FOB49_RS137552815108..2815671+564WP_015704609.1maltose O-acetyltransferase-
FOB49_RS137652815797..2816261+465WP_015367920.1YlaC family protein-
FOB49_RS137702816236..2817690-1455WP_015704608.1PLP-dependent aminotransferase family protein-
FOB49_RS137752817793..2818503+711WP_015704607.1GNAT family N-acetyltransferase-
FOB49_RS137802818500..2818640-141WP_003859006.1type B 50S ribosomal protein L36-
FOB49_RS137852818643..2818903-261WP_015367923.1type B 50S ribosomal protein L31-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8569.96 Da        Isoelectric Point: 9.4828

>T140021 WP_015367918.1 NZ_CP044083:2814758-2814976 [Klebsiella aerogenes]
MSGKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T140021 NZ_CP058875:c130010-129612 [Escherichia coli]
ATGCTGAAGTTTATGCTCGATACCAACATCTGCATTTTCACGATGAAGAACAAACCCGCCAGCGTCAGGGAGCGTTTTAA
CCTGAACCAGGGGAGAATGTGTATCAGTTCGGTCACCCTGATGGAGCTGATATATGGTGCAGAAAAAAGCCAGATGCCTG
AACGTAATCTCGCTGTGATCGAGGGATTTGTTTCCCGCATTGATGTTCTGGATTACGACGCTGCCGCAGCCACACACAGC
GGCCAGATAAGAGCAGAACTTGCCCGTCAGGGACGCCCTGTCGGGCCATTTGATCAAATGATCGCAGGTCATGCCCGCAG
TCGGGGACTGATTATTGTGACTAATAACACCCGGGAATTTGAACGTGTGGACGGTCTGAGAATTGAAGACTGGAGCTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14464.21 Da        Isoelectric Point: 4.9045

>AT140021 WP_015367917.1 NZ_CP044083:2814357-2814731 [Klebsiella aerogenes]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNRGWVNDPTSAVNLQLNELIEHIATYALNYKIKYAEDNKLISQLDEYL
DDTFMLFSSYGINTSDLQKWRKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT140021 NZ_CP058875:c130237-130010 [Escherichia coli]
ATGGAAACCACCGTATTTTTCAGCAACCGCAGCCAGGCGGTCAGACTGCCAAAAGCGGTTGCATTGCCGGAAAACGTAAA
ACGCGTTGAAGTGATTGCTGTCGGACGAACCAGAATCATTACGCCAGCCGGAGAGACATGGGACGAATGGTTCGACGGAC
ACAACGTCAGCGCCGATTTTATGGATAACAGGGAACAGCCCGGCATGCAGGAAAGGGAGTCATTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0H3FXE2

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A0H3FPM3

References