Detailed information of TA system TA140011

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-Phd
• Location: 201633..202304
• Replicon: plasmid unnamed4
• Accession: NZ_CP044082
• Organism: Paracoccus yeei strain FDAARGOS_643

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: FOB51_RS22640
• Protein ID: WP_150352013.1
• Coordinates: 201888..202304 (+)
• Length: 139 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: FOB51_RS22635
• Protein ID: WP_150352012.1
• Coordinates: 201633..201887 (+)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FOB51_RS22620	196775..198787	-	2013	WP_150352010.1	cytochrome o ubiquinol oxidase subunit I	-
FOB51_RS22625	198800..200005	-	1206	WP_150352011.1	ubiquinol oxidase subunit II	-
FOB51_RS22630	200212..201519	+	1308	WP_120444427.1	MFS transporter	-
FOB51_RS22635	201633..201887	+	255	WP_150352012.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
FOB51_RS22640	201888..202304	+	417	WP_150352013.1	type II toxin-antitoxin system VapC family toxin	Toxin
FOB51_RS22645	202451..203839	+	1389	WP_150352014.1	L-cystine transporter	-
FOB51_RS22650	203908..204303	+	396	WP_028720783.1	acyl-CoA thioesterase	-
FOB51_RS22655	204323..205606	-	1284	WP_150352015.1	lytic murein transglycosylase	-
FOB51_RS22660	205683..206687	-	1005	WP_150352016.1	GTP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..274662	274662

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-119)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (2-51)

Sequences

Toxin

Protein

• Length: 139 a.a.
• Molecular weight: 14892.99 Da
• Isoelectric Point: 5.6964

>T140011 WP_150352013.1 NZ_CP044082:201888-202304 [Paracoccus yeei]
MLILDTNVLSALRRPERSPAVAAWLARQDDTALYLSVVTLGEIERGIVRQESQNPPFARDLRDWLTRTVTLFSDRLLPFG
ATEALLWGQLSARLGHAGADLLIAATALAHDAAVVTGNTADFRPTGCRLVDPFAQGAG

Nucleotide

• Length: 417 bp

>T140011 NZ_CP058874:2801618-2801725 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGGATTATTACCGCAGTGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 8878.11 Da
• Isoelectric Point: 11.3324

>AT140011 WP_150352012.1 NZ_CP044082:201633-201887 [Paracoccus yeei]
MWTLQDAKNRFSAVVDAALAGQPQQVTRRGKPAVVVLAAADYARMLAATQENRGSFAAHLLSFPGPDLGPGSGRARVAPR
DVSF

Nucleotide

• Length: 255 bp

>AT140011 NZ_CP058874:c2801565-2801504 [Escherichia coli]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT