Detailed information of TA system TA140010

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-Phd
• Location: 1647211..1647894
• Replicon: chromosome
• Accession: NZ_CP044081
• Organism: Paracoccus yeei strain FDAARGOS_643

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: FOB51_RS11785
• Protein ID: WP_112887237.1
• Coordinates: 1647466..1647894 (+)
• Length: 143 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: FOB51_RS11780
• Protein ID: WP_150350663.1
• Coordinates: 1647211..1647462 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FOB51_RS11750	1643301..1643624	+	324	WP_190941616.1	transposase	-
FOB51_RS11755	1643624..1644340	+	717	Protein_1600	ABC transporter ATP-binding protein	-
FOB51_RS11760	1644337..1644978	+	642	WP_051578028.1	ATP-binding cassette domain-containing protein	-
FOB51_RS11765	1645077..1646126	-	1050	WP_150350662.1	hypothetical protein	-
FOB51_RS11770	1646363..1646563	+	201	Protein_1603	hypothetical protein	-
FOB51_RS11775	1646963..1647157	+	195	Protein_1604	DUF3363 domain-containing protein	-
FOB51_RS11780	1647211..1647462	+	252	WP_150350663.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
FOB51_RS11785	1647466..1647894	+	429	WP_112887237.1	PIN domain-containing protein	Toxin
FOB51_RS11790	1648139..1648373	+	235	Protein_1607	transposase	-
FOB51_RS11795	1648397..1648807	-	411	WP_150350664.1	hypothetical protein	-
FOB51_RS11800	1648900..1650966	-	2067	WP_150349268.1	AAA family ATPase	-
FOB51_RS23175	1651093..1652064	-	972	WP_190941264.1	hypothetical protein	-
FOB51_RS11810	1652234..1652869	-	636	WP_150350665.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1645077..1688826	43749
	-	flank	IS/Tn	-	-	1643301..1643624	323

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-124)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-65)

Sequences

Toxin

Protein

• Length: 143 a.a.
• Molecular weight: 15212.44 Da
• Isoelectric Point: 7.4675

>T140010 WP_112887237.1 NZ_CP044081:1647466-1647894 [Paracoccus yeei]
MYLLDTNIVSASAPTRRDTDVLAAWMRVHSDRLYLSAITIAEIEAGIARAVRIGASSKAPALRRWLAAVEHFYASRILAF
GIEEARQAGAILDQARAHGPGFEDIAIAATAAAHGLTVLTANERHFAPLGVPYANPLKELPA

Nucleotide

• Length: 429 bp

>T140010 NZ_CP058874:c2561361-2561185 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTGGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCAAGGGCGACGCAGTGTCATGCCGCGTCACCCCAGTGATGAGATAAAAGAACCATTGCGTAAAGCAATCCTGAAGC
AACTCGGTTTAAATTAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9275.64 Da
• Isoelectric Point: 7.0152

>AT140010 WP_150350663.1 NZ_CP044081:1647211-1647462 [Paracoccus yeei]
MKELQLRDAKATLSAVVDQAVAGEPTVITRHGRKEAVLLSFEEWQRISRVPDVADLLLAFPGQPEDIPERTRKPARALRD
TSL

Nucleotide

• Length: 252 bp

>AT140010 NZ_CP058874:c2561141-2560725 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACTCCTGCGCCGGAAGGCGGTTATGTGGTTTCTTTTGTAGATATCCCTGAAGCGTTGAC
GCAGGGAGAAACTGTTGCTGAAGCGATGGAAGCAGCAAAAGATGCCTTACTCACCGCATTTGATTTTTATTTTGAAGATA
ATGAGCTAATCCCGTTGCCTTCGCCATTAACTAACAACGATCACTTTATTGAAGTGCCTTTAAGTATCGCCTCTAAAGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGACGAATTGGCAAACCTAAACAGGAGAT
TACTCGCTTATTTAACTTGCACCATGCTACAAAAATCGACGCCGTCCAGCTTGCGGCTAAGGCGCTTGGCAAAGAGTTAT
CACTGGTGATGGTTTGA