Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1978079..1978730 Replicon chromosome
Accession NZ_CP044076
Organism Providencia stuartii strain FDAARGOS_645

Toxin (Protein)


Gene name Hha Uniprot ID K8W3H1
Locus tag FOB53_RS10385 Protein ID WP_004927064.1
Coordinates 1978527..1978730 (+) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID B2Q721
Locus tag FOB53_RS10380 Protein ID WP_004927067.1
Coordinates 1978079..1978447 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOB53_RS10355 1973216..1973977 - 762 WP_150375962.1 DNA polymerase III subunit epsilon -
FOB53_RS10360 1974032..1974502 + 471 WP_014656762.1 ribonuclease HI -
FOB53_RS10365 1974581..1975306 - 726 WP_040132836.1 methyltransferase domain-containing protein -
FOB53_RS10370 1975340..1976095 + 756 WP_004927081.1 hydroxyacylglutathione hydrolase -
FOB53_RS10375 1976174..1977511 + 1338 WP_004927077.1 murein transglycosylase D -
FOB53_RS10380 1978079..1978447 + 369 WP_004927067.1 Hha toxicity modulator TomB Antitoxin
FOB53_RS10385 1978527..1978730 + 204 WP_004927064.1 hemolysin expression modulator Hha Toxin
FOB53_RS10395 1979336..1979794 - 459 WP_004927062.1 YbaY family lipoprotein -
FOB53_RS10400 1980117..1980983 + 867 WP_150375964.1 acyl-CoA thioesterase II -
FOB53_RS10405 1981220..1982503 - 1284 WP_014656764.1 ammonium transporter AmtB -
FOB53_RS10410 1982514..1982852 - 339 WP_004927053.1 P-II family nitrogen regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8075.37 Da        Isoelectric Point: 6.9770

>T140007 WP_004927064.1 NZ_CP044076:1978527-1978730 [Providencia stuartii]
MTKTDYLMRLRKCTTIDTLERVIEKNKYELSEDELELFYSAADHRLAELTMNKLYDKIPASVWKFVR

Download         Length: 204 bp

>T140007 NZ_CP058874:1388468-1388866 [Escherichia coli]
ATGCTGAAATTCATGCTGGATACCAACATCTGTATTTTCACTATTAAGAATAAACCAGTACATGTCAGAGAGCGGTTTAA
CCTGAATTCTGGCCGGATGTGTATAAGTTCTGTAACATTGATGGAGCTTATCTATGGGGCAGAAAAAAGTCAGATGCCAG
AACGCAATTTGGCGGTGATTGAAGGTTTCGTATCTCGTTTGGAAGTGCTTGATTATGATAGTGCTGCTGCGACGCATACT
GGGCAAATCAGGGCCGAGTTTGCCCGGCAGGGAAGGCCTGTTGGACCTTTTGACCAGATGATAGCGGGACATGCTCGCAG
TCGCGGTTTGATTGTGGTAACCAACAATACCCGAGAGTTTGAGCGAGTGGCGGGAATCAGACTAGAAGACTGGAGCTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14149.01 Da        Isoelectric Point: 4.2591

>AT140007 WP_004927067.1 NZ_CP044076:1978079-1978447 [Providencia stuartii]
MDEYSPKNYDISELKYLCNSLNREAMLSLQKTNTHWVNDLSSPQSARLNELIEHIAAFVWQFKIKYPKENLVISLVEEYL
DETYDLFGSPVITLSEIIDWQSMNQNLVSVLDDDLKCPASKT

Download         Length: 369 bp

>AT140007 NZ_CP058874:1388241-1388468 [Escherichia coli]
ATGGAAACTACTGTATTTTTAAGTAATCGCAGTCAGGCCGTCAGATTACCGAAAGCGGTCGCTCTGCCAGAGGACGTTAA
GAAAGTAGAAATTATTGCGATTGGTCGTACAAGAATCATCACTCCCGCCGGTGAGTCCTGGGACAGTTGGTTTGATGGCG
AAAATGTGAGTGCGGATTTTATGGATATCCGTGATCAACCCGCAATGCAGGAAAGGGAATCATTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB K8W3H1

Antitoxin

Source ID Structure
AlphaFold DB A0A140NKN2

References