Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1296728..1297385 Replicon chromosome
Accession NZ_CP044076
Organism Providencia stuartii strain FDAARGOS_645

Toxin (Protein)


Gene name cptA Uniprot ID A0A7T1H2A7
Locus tag FOB53_RS07295 Protein ID WP_036941148.1
Coordinates 1296728..1297138 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID B2Q1I8
Locus tag FOB53_RS07300 Protein ID WP_004921708.1
Coordinates 1297119..1297385 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOB53_RS07275 1292615..1294348 - 1734 WP_150375774.1 single-stranded-DNA-specific exonuclease RecJ -
FOB53_RS07280 1294354..1295058 - 705 WP_004921696.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
FOB53_RS07285 1295078..1296001 - 924 WP_150375776.1 site-specific tyrosine recombinase XerD -
FOB53_RS07290 1296164..1296682 + 519 WP_014656387.1 flavodoxin FldB -
FOB53_RS07295 1296728..1297138 - 411 WP_036941148.1 membrane protein Toxin
FOB53_RS07300 1297119..1297385 - 267 WP_004921708.1 FAD assembly factor SdhE Antitoxin
FOB53_RS07305 1297638..1298627 + 990 WP_004921711.1 tRNA-modifying protein YgfZ -
FOB53_RS07310 1298639..1299259 + 621 WP_004921714.1 HD domain-containing protein -
FOB53_RS07315 1299478..1302354 - 2877 WP_088499134.1 aminomethyl-transferring glycine dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-133)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 15289.15 Da        Isoelectric Point: 10.8779

>T140006 WP_036941148.1 NZ_CP044076:c1297138-1296728 [Providencia stuartii]
VVLWKSNLSISWKTQLFSTCAHGVVGFILLVAPWAPGNSMVWLPLLVIVIASWAKSQKSISKIKGTAVLVNGNKVQWKKN
EWSIVKQPWCSRVGVLLTLSALQGKPQKIRLWVAKDALSEESWRNLNQLLLQYPDI

Download         Length: 411 bp

>T140006 NZ_CP058874:953361-953768 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGCATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGACAGCGGAAAACGGCA
ACATTTATGGCTGGCAGCTGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATATTGTTACAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10576.10 Da        Isoelectric Point: 4.9104

>AT140006 WP_004921708.1 NZ_CP044076:c1297385-1297119 [Providencia stuartii]
MDIENKARIHWACRRGMRELDISIMPFFEYEYEGLSDKDKRTFVRLLECADPDLFNWLMNHGRPDDDELFGMVKLIQERN
KNRGPVEI

Download         Length: 267 bp

>AT140006 NZ_CP058874:953114-953380 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCAGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7T1H2A7

Antitoxin

Source ID Structure
AlphaFold DB A0A140NIX0

References