Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 4195493..4196136 Replicon chromosome
Accession NZ_CP044074
Organism Pseudomonas oryzihabitans strain FDAARGOS_657

Toxin (Protein)


Gene name vapC Uniprot ID A0A1G5NTI6
Locus tag FOB65_RS20890 Protein ID WP_074584223.1
Coordinates 4195723..4196136 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A329HNZ8
Locus tag FOB65_RS20885 Protein ID WP_027597360.1
Coordinates 4195493..4195723 (+) Length 77 a.a.

Genomic Context

FOB65_RS20870FOB65_RS20875FOB65_RS20885FOB65_RS20890FOB65_RS20895FOB65_RS20900FOB65_RS20905FOB65_RS20880
Location: 4190883..4192742 (1860 bp)
Type: Others
Protein ID: WP_190971329.1
Location: 4192739..4193455 (717 bp)
Type: Others
Protein ID: WP_150340421.1
Location: 4195493..4195723 (231 bp)
Type: Antitoxin
Protein ID: WP_027597360.1
Location: 4195723..4196136 (414 bp)
Type: Toxin
Protein ID: WP_074584223.1
Location: 4196434..4196802 (369 bp)
Type: Others
Protein ID: WP_007159937.1
Location: 4196810..4199665 (2856 bp)
Type: Others
Protein ID: WP_150340423.1
Location: 4199878..4200987 (1110 bp)
Type: Others
Protein ID: WP_074584221.1
Location: 4193474..4195198 (1725 bp)
Type: Others
Protein ID: WP_042134704.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
FOB65_RS208704190883..4192742+1860WP_190971329.1GGDEF domain-containing protein-
FOB65_RS208754192739..4193455+717WP_150340421.1transporter substrate-binding domain-containing protein-
FOB65_RS208804193474..4195198-1725WP_042134704.1ubiquinone-dependent pyruvate dehydrogenase-
FOB65_RS208854195493..4195723+231WP_027597360.1AbrB/MazE/SpoVT family DNA-binding domain-containing proteinAntitoxin
FOB65_RS208904195723..4196136+414WP_074584223.1tRNA(fMet)-specific endonuclease VapCToxin
FOB65_RS208954196434..4196802+369WP_007159937.1glycine cleavage system protein GcvH-
FOB65_RS209004196810..4199665+2856WP_150340423.1aminomethyl-transferring glycine dehydrogenase-
FOB65_RS209054199878..4200987+1110WP_074584221.1glycine cleavage system aminomethyltransferase GcvT-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-124)

Antitoxin

SpoVT-AbrB domain

(7-53)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 15132.33 Da        Isoelectric Point: 7.8849

>T140004 WP_074584223.1 NZ_CP044074:4195723-4196136 [Pseudomonas oryzihabitans]
MLKFMLDTNTCIFTIKNRPTSVREAFTRHQGQLCISTITLMELIYGAEKSSSPERNLAVIEGFAARLEVLTYGPEAAAHT
GQLRAELARAGQQIGPYDQMIAGHARSLGLIVVTNNRREFDRVPGLRVEDWVTAAGN

Download         Length: 414 bp

>T140004 NZ_CP058874:381956-382333 [Escherichia coli]
ATGACCATTCAGTTTATCTCAGCGGAGGAGATAATTTATTTCCACGATAAATTGCTTAGCGTTACACCAGGTGTAACAGG
AATGTCCGATCCAGGGCGAGCAGAAGCGCTTTTGTACCGGGTACTGAATAAGTATGAGTATGAAGGCGTTTCTGATCTTT
GGTTGCTGGCGGCGATGCATCTATTGGCAATCTCGCGCGGTCATATCTTTAATGATGGTAATAAGCGCACCGCACTGTTT
ATCACGCTATTATTCCTTAAACGTAACGGCATCATACTTGCTGCAAACCCAGAGTTTGTAGAATTGACGGTTGATGTGGC
GGCGGGAAAAGTATCGTTAGAAGATATCGTTACCCGCTTGCGTCAACGCGGTACCTGA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8378.32 Da        Isoelectric Point: 4.3867

>AT140004 WP_027597360.1 NZ_CP044074:4195493-4195723 [Pseudomonas oryzihabitans]
MDQGAVFQSNRSQAVRLPKAVALPADVKRVDVVAVGRTRIITPAGESWDSWFEGEGVTADFMAERDQPAEQEREGF

Download         Length: 231 bp

>AT140004 NZ_CP058874:381738-381959 [Escherichia coli]
ATGCATACCATGAACTACAGCGAAGCGCGGCAGAACCTTGCATTAGTTCTGGAAACAGCGGCGACAGGTACTCCGGTAAC
GATCACGAGGCGTGGGCATAAGGCAGCTGTGATTATCAGCGCAGAAGAGTTTGAACGTTACCAGAAGGCTAAACTGGACG
CAGAATTTGACGCCATCATGGCTATTCATGGCAGCGAAATTAAGGAGTTAGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A1G5NTI6

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A329HNZ8

References