Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 3416461..3417098 Replicon chromosome
Accession NZ_CP044074
Organism Pseudomonas oryzihabitans strain FDAARGOS_657

Toxin (Protein)


Gene name vapC Uniprot ID A0A1G5PE31
Locus tag FOB65_RS17280 Protein ID WP_074584946.1
Coordinates 3416685..3417098 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name VapB1 Uniprot ID -
Locus tag FOB65_RS17275 Protein ID WP_150339891.1
Coordinates 3416461..3416685 (+) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOB65_RS17260 3412773..3413414 + 642 WP_017642883.1 oxidoreductase -
FOB65_RS17265 3413957..3414892 - 936 WP_017642882.1 LysR family transcriptional regulator -
FOB65_RS17270 3415019..3416395 + 1377 WP_150339888.1 L-serine ammonia-lyase -
FOB65_RS17275 3416461..3416685 + 225 WP_150339891.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
FOB65_RS17280 3416685..3417098 + 414 WP_074584946.1 type II toxin-antitoxin system VapC family toxin Toxin
FOB65_RS17285 3417139..3417615 + 477 WP_042137327.1 YbaK/EbsC family protein -
FOB65_RS17290 3417877..3419280 + 1404 WP_150339893.1 PLP-dependent aminotransferase family protein -
FOB65_RS17295 3419277..3419549 - 273 WP_027601095.1 YceK/YidQ family lipoprotein -
FOB65_RS17300 3419743..3420375 - 633 WP_007161189.1 flavin prenyltransferase UbiX -
FOB65_RS17305 3420375..3421730 - 1356 WP_150339896.1 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-126)

Antitoxin

SpoVT-AbrB domain

(7-42)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 15482.62 Da        Isoelectric Point: 6.9499

>T140002 WP_074584946.1 NZ_CP044074:3416685-3417098 [Pseudomonas oryzihabitans]
VPARYLLDTNICIYIAKHNPPQVRERFARHGRDELAMSAITWGELCHGAAKSQQPERTRAILEQLRQQIAVLELDAECAE
HYGAIRAELERQGKIIGNNDLWIAAHARARALILVSNNLREFSRIADLACENWTAAD

Download         Length: 414 bp

>T140002 NZ_CP058874:274604-274711 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGCATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8557.61 Da        Isoelectric Point: 4.6561

>AT140002 WP_150339891.1 NZ_CP044074:3416461-3416685 [Pseudomonas oryzihabitans]
MAEARVFKSGNSQALRLPKEFRFESDRVEIFRRGNEIVLRELRPDAADIFDTLAALSFATLEREDSPPQAREEF

Download         Length: 225 bp

>AT140002 NZ_CP058874:c274547-274489 [Escherichia coli]
TCAAGAATGGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1G5PE31

Antitoxin

Source ID Structure

References