Detailed information of TA system TA139996

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 2369730..2371291
• Replicon: chromosome
• Accession: NZ_CP044069
• Organism: Vibrio vulnificus strain FDAARGOS_663

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: FOB71_RS19000
• Protein ID: WP_017422047.1
• Coordinates: 2369730..2371058 (-)
• Length: 443 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: FOB71_RS19005
• Protein ID: WP_017422048.1
• Coordinates: 2371052..2371291 (-)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FOB71_RS18975	2364903..2365367	-	465	WP_011079944.1	DUF2846 domain-containing protein	-
FOB71_RS18980	2365569..2366621	-	1053	WP_017422044.1	GGDEF domain-containing protein	-
FOB71_RS18985	2366759..2367394	-	636	WP_017422045.1	magnesium transporter	-
FOB71_RS18995	2368211..2369536	+	1326	WP_017422046.1	site-specific integrase	-
FOB71_RS19000	2369730..2371058	-	1329	WP_017422047.1	type II toxin-antitoxin system HipA family toxin	Toxin
FOB71_RS19005	2371052..2371291	-	240	WP_017422048.1	helix-turn-helix domain-containing protein	Antitoxin
FOB71_RS19010	2371947..2373755	+	1809	WP_017422049.1	hypothetical protein	-
FOB71_RS19015	2374712..2375092	-	381	WP_049798924.1	winged helix-turn-helix transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	2369730..2383421	13691

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (6-104)

Antitoxin

• Cro/C1-type helix-turn-helix domain (10-55)

Sequences

Toxin

Protein

• Length: 443 a.a.
• Molecular weight: 49488.85 Da
• Isoelectric Point: 9.4372

>T139996 WP_017422047.1 NZ_CP044069:c2371058-2369730 [Vibrio vulnificus]
MVSRLHAYMNGLKVGVLEKRTNGAHVFTYDSGWISAPNSRPISLSMPLRKGAYTGSEVINFFDNLLPDNQQIRDRIAARY
KADTKQPFDLLAKVGRDAVGAITLVPEGFDVDDHRVITAKALSDKELVRILKGYMEGAPLGMLKEEDDFRISIAGAQEKT
ALLFHDGRWMLPQGMTPTTHIIKLPIGEIVSQNNVIDLSASVDNELICMRLAKAFGIQTANCDIIRAGDVRALSVERFDR
KLSSDNSYYLRLPHEDFCQAKGIPSARKYEIDGGIGIEESIDILRYSYEINDTVTFARSQILFWLLAAIDGHGKNFSVSI
AASGRYQLAPLYDIISAHPLAGGRGLSERKIKMAMSLRGTSGRKWKWHQLQPRHFEDTFHTMNVPNIRREKVRLLLDEFE
STARAVIDSVGNSLPTDINESVRDKIFNGVLKTVKKIQLTKK

Nucleotide

• Length: 1329 bp

>T139996 NZ_CP058870:c134732-134250 [Klebsiella pneumoniae]
ATGGGAATGAGAGCGCCTGAATCCCTGACGGCTGAACATAACATCGCTGAGTTCTGCTGCCAGGAGCCTGCCCTTAATGA
GTGGTTAAAGAAGAAGGCTCTCAGAAACCACAGTACCGGCATTTCCCGTGTCTATGTCGTCTGCGCAGAAAACACTAACC
GGGTCATCGGTTATTATTGTTTATCTTCGGGTAGCGTCCACCGTAACACAGTGCCTGGGGCCTATAGACGCAACGCGCCT
GATGTCATTCCAGTCATTGTTTTGGGACGGCTTGCCATCGACCAGGCCTGGGCCGGGAATGGGCTTGGTGCCGCACTTCT
TAAGGATGCTATATACCGTACGCAAAACATAGCCTTTCAGGTCGGGGTGAGAGCACTGGCCGTGCATGCGCTGAATGAAG
AAGTTAAATGTTTTTACACCCGTTTTGGCTTTGAGCCTTCCATAGTCAACACGCTGACATTGTTATTCCCGATAAAAGTC
TGA

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 8703.93 Da
• Isoelectric Point: 7.2034

>AT139996 WP_017422048.1 NZ_CP044069:c2371291-2371052 [Vibrio vulnificus]
MLVNTPTALGNALREARKDNGLKQTDLGLRQATVSNFESNPEKSTIDTLFKLLSINGLEMHIVPKGKHITETKGAVDEW

Nucleotide

• Length: 240 bp

>AT139996 NZ_CP058870:c135001-134723 [Klebsiella pneumoniae]
ATGAAACCAGACGTTCGTGAAGCTCCGATTAATATCCGGGCCAAAACATCACAGCGTGACCTGATCGACATGGCCGCAAG
CCTGGTCTCAAAATCACGGACTGATTTTATGCTTGAGGTTGCCTGCAGGGAGGCACAGGACATTCTGCTTGATCAACGCC
TGTTCCTCCTCAATGACAATCAGTTTGAGGCGTTTATTGAAGAGCTTGACGCCCCAATAACGCCGGAGCGCCAGGCGCGA
ATCGATAACCTGATGAACCGCAAATCACCATGGGAATGA