Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /GNAT-DUF1778
Location 1891447..1892213 Replicon chromosome
Accession NZ_CP044069
Organism Vibrio vulnificus strain FDAARGOS_663

Toxin (Protein)


Gene name - Uniprot ID A0A2K7SQA7
Locus tag FOB71_RS16520 Protein ID WP_017420533.1
Coordinates 1891716..1892213 (+) Length 166 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A347UQX1
Locus tag FOB71_RS16515 Protein ID WP_017420534.1
Coordinates 1891447..1891719 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOB71_RS16475 1886711..1888072 - 1362 WP_017420792.1 group II intron reverse transcriptase/maturase -
FOB71_RS16485 1888903..1889367 + 465 WP_017420537.1 hypothetical protein -
FOB71_RS16490 1889440..1889721 - 282 WP_017420536.1 hypothetical protein -
FOB71_RS16495 1889747..1889869 - 123 WP_080586384.1 DUF3265 domain-containing protein -
FOB71_RS16500 1890231..1890320 - 90 WP_072599486.1 DUF3265 domain-containing protein -
FOB71_RS16505 1890357..1890770 - 414 WP_017420535.1 hypothetical protein -
FOB71_RS16510 1891245..1891406 - 162 WP_072609931.1 DUF3265 domain-containing protein -
FOB71_RS16515 1891447..1891719 + 273 WP_017420534.1 DUF1778 domain-containing protein Antitoxin
FOB71_RS16520 1891716..1892213 + 498 WP_017420533.1 GNAT family N-acetyltransferase Toxin
FOB71_RS23235 1892236..1892393 - 158 Protein_1733 DUF3265 domain-containing protein -
FOB71_RS16530 1892377..1892901 - 525 WP_026050331.1 GNAT family N-acetyltransferase -
FOB71_RS16535 1892861..1893028 - 168 WP_089529809.1 DUF3265 domain-containing protein -
FOB71_RS16540 1893444..1894805 - 1362 WP_017420792.1 group II intron reverse transcriptase/maturase -
FOB71_RS16545 1895307..1895402 - 96 WP_089529808.1 DUF3265 domain-containing protein -
FOB71_RS16550 1895450..1895971 - 522 WP_017420800.1 hypothetical protein -
FOB71_RS23240 1895935..1896027 - 93 WP_172840603.1 DUF3265 domain-containing protein -
FOB71_RS16560 1896042..1896785 - 744 WP_026050387.1 hypothetical protein -
FOB71_RS16565 1896862..1896929 - 68 Protein_1741 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1799768..1962721 162953
- inside Integron - - 1801327..1962721 161394


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(86-151)

Antitoxin

Vibrio phage ICP1, Orf50

(7-86)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 18467.13 Da        Isoelectric Point: 8.8117

>T139995 WP_017420533.1 NZ_CP044069:1891716-1892213 [Vibrio vulnificus]
MMNTVLLDKAKHDRNRFNCGIEALNNYLKVMASQQAKKDNTRTFVLEDDSDNSHVIGFYTLTMTPIDLKALPDKLQKKHQ
SSTSGGLIARLAVDDRYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYERYGFQAFHDAENKLFITIADV
RASLG

Download         Length: 498 bp

>T139995 NZ_CP058870:55948-56418 [Klebsiella pneumoniae]
GTGATCCTCTACAGGCTGACGAAAACAAAGTATCTTTCTACGGCCTGGACCGGATATGGTGCGAAAGAGGCTGGTGGGCG
CTGGAATAGCGTGGGGGTGTCAATGGTATATGTCTCCGAAACGGCATCACTAACGATGCTGGAGACCCTGGTACACCTGC
ATGCGGCACAGATAATGGACTCTTTCACGCTACTGAGTATCGATGTGCCTGATGAACTGATACAAAGCGCAAACATGGAT
GAATTACCGGGCAACTGGGCTGATGAGGATGCGCCTCAGGAACTGGCTGATTACGGAGATGCCTGGTCATTTACCAGGAG
CTCGGTTGCACTGCGTGTTCCCTCAGCCTTATCGCCGGTAGAGTTCAATTATCTGTTAAATCCTGAGCACCCTGAGTTTT
ACGGGATCGTGCAGAAGGCTCAACAGATACCGTTCCGGTTTGATAGTCGTCTTAAACCTGACAGGAAGTGA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9735.22 Da        Isoelectric Point: 8.5960

>AT139995 WP_017420534.1 NZ_CP044069:1891447-1891719 [Vibrio vulnificus]
MATTLPRITARVDVDTQDLLTKAAAIAGMSSINSFVLSAAIEKAKQVIEREQALKLSQADAMLLMEALDRPATQNSKLKA
AADRYESKTQ

Download         Length: 273 bp

>AT139995 NZ_CP058870:55508-55951 [Klebsiella pneumoniae]
ATGAAAACTTTTAGTTTGTCCTCAACTCCAGCCAGACCACAGCGCCTCTGGCAGGTTGCCGGGTTAAATAATGCTGATGG
TGTAGCGCTCCTGGGCCAAATCAATGAAGGCCTGGACGGGAAGGTGGTGAACCGGATCACTGACTGGGCCAGAATAACCC
AGAATGACCTGAGAAAAATGTCCGGTATCCCGTCAACCACATTTAGCCGCAGTGTGAAGGCACGTTTTAACCCGGAACAA
AGTGAACGTCTGGTACGGATTATCCGCGTTATTGATCGGGCGGTAGATTTGTTTGAAGGCGACAGGGAAGCCGCACAGAA
GTGGTTGAACGAACCTAACCGGGCATTGAGCTGGAAAGTGCCAGCAGACCTGATGGCATCCGAAACGGGAGCCTATGAGG
TCATTAAGCTGATTACGCGTCTGGAGCATGGGGTGTACTCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2K7SQA7

Antitoxin

Source ID Structure
AlphaFold DB A0A347UQX1

References