Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relB-yefM/YoeB-RelB |
| Location | 1864198..1864714 | Replicon | chromosome |
| Accession | NZ_CP044069 | ||
| Organism | Vibrio vulnificus strain FDAARGOS_663 | ||
Toxin (Protein)
| Gene name | relB | Uniprot ID | - |
| Locus tag | FOB71_RS16210 | Protein ID | WP_026050329.1 |
| Coordinates | 1864198..1864467 (-) | Length | 90 a.a. |
Antitoxin (Protein)
| Gene name | yefM | Uniprot ID | A0A0A5HTW2 |
| Locus tag | FOB71_RS16215 | Protein ID | WP_017420636.1 |
| Coordinates | 1864460..1864714 (-) | Length | 85 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| FOB71_RS16160 | 1859382..1859624 | + | 243 | WP_011080384.1 | type II toxin-antitoxin system ParD family antitoxin | - |
| FOB71_RS16165 | 1859621..1859920 | + | 300 | WP_017420621.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| FOB71_RS16170 | 1860044..1861000 | - | 957 | WP_017420620.1 | hypothetical protein | - |
| FOB71_RS16175 | 1861037..1861177 | - | 141 | WP_004401153.1 | DUF3265 domain-containing protein | - |
| FOB71_RS16180 | 1861152..1861619 | - | 468 | WP_017420618.1 | NUDIX domain-containing protein | - |
| FOB71_RS16185 | 1861636..1861758 | - | 123 | WP_072604788.1 | DUF3265 domain-containing protein | - |
| FOB71_RS16195 | 1862582..1862716 | - | 135 | WP_115173853.1 | DUF3265 domain-containing protein | - |
| FOB71_RS16200 | 1863052..1863180 | - | 129 | WP_089529830.1 | DUF3265 domain-containing protein | - |
| FOB71_RS16205 | 1863538..1863648 | - | 111 | Protein_1676 | DUF3265 domain-containing protein | - |
| FOB71_RS16210 | 1864198..1864467 | - | 270 | WP_026050329.1 | Txe/YoeB family addiction module toxin | Toxin |
| FOB71_RS16215 | 1864460..1864714 | - | 255 | WP_017420636.1 | type II toxin-antitoxin system prevent-host-death family antitoxin | Antitoxin |
| FOB71_RS16220 | 1864806..1864928 | - | 123 | WP_080586381.1 | DUF3265 domain-containing protein | - |
| FOB71_RS16225 | 1864925..1865245 | - | 321 | WP_026050328.1 | hypothetical protein | - |
| FOB71_RS16230 | 1865704..1866144 | - | 441 | WP_017420638.1 | hypothetical protein | - |
| FOB71_RS16235 | 1866602..1867474 | - | 873 | WP_017428724.1 | hypothetical protein | - |
| FOB71_RS16240 | 1867519..1867641 | - | 123 | Protein_1683 | DUF3265 domain-containing protein | - |
| FOB71_RS16245 | 1867725..1868087 | + | 363 | WP_017420640.1 | glyoxalase | - |
| FOB71_RS23225 | 1868556..1868696 | - | 141 | WP_080589825.1 | DUF3265 domain-containing protein | - |
| FOB71_RS16260 | 1869541..1869651 | - | 111 | WP_080586398.1 | DUF3265 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 1799768..1962721 | 162953 | |
| - | inside | Integron | - | - | 1801327..1962721 | 161394 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 90 a.a. Molecular weight: 10600.93 Da Isoelectric Point: 7.9815
>T139994 WP_026050329.1 NZ_CP044069:c1864467-1864198 [Vibrio vulnificus]
MSSSQRLLSWTDDAWDDYLYWQTQDKKTLKRINKLINDVKRSPFDGIGKPEPLKENLSGFWSRRIDDTNRLVYAVDDQAI
TIISCRYHY
MSSSQRLLSWTDDAWDDYLYWQTQDKKTLKRINKLINDVKRSPFDGIGKPEPLKENLSGFWSRRIDDTNRLVYAVDDQAI
TIISCRYHY
Download Length: 270 bp
>T139994 NZ_CP058869:c5170581-5170198 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCATCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCATCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA
Antitoxin
Download Length: 85 a.a. Molecular weight: 9453.65 Da Isoelectric Point: 5.6785
>AT139994 WP_017420636.1 NZ_CP044069:c1864714-1864460 [Vibrio vulnificus]
MRIVSFTEARNGLKAVLDGVVNDADTTVITRRDSEDAVVMSLDYYNSLMETVHLLRSPKNAEHLNRSIAQYRAGKTTARE
LIDE
MRIVSFTEARNGLKAVLDGVVNDADTTVITRRDSEDAVVMSLDYYNSLMETVHLLRSPKNAEHLNRSIAQYRAGKTTARE
LIDE
Download Length: 255 bp
>AT139994 NZ_CP058869:c5170823-5170581 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|