Detailed information of TA system TA139993

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-RHH
• Location: 1859382..1859920
• Replicon: chromosome
• Accession: NZ_CP044069
• Organism: Vibrio vulnificus strain FDAARGOS_663

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: FOB71_RS16165
• Protein ID: WP_017420621.1
• Coordinates: 1859621..1859920 (+)
• Length: 100 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A0F2HR74
• Locus tag: FOB71_RS16160
• Protein ID: WP_011080384.1
• Coordinates: 1859382..1859624 (+)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FOB71_RS16095	1854547..1854672	-	126	WP_017420646.1	DUF3265 domain-containing protein	-
FOB71_RS16100	1854669..1855001	-	333	WP_017420647.1	hypothetical protein	-
FOB71_RS16110	1855148..1855573	-	426	WP_017420648.1	hypothetical protein	-
FOB71_RS16115	1855583..1855693	-	111	WP_080586402.1	DUF3265 domain-containing protein	-
FOB71_RS16120	1855722..1856108	-	387	WP_000260420.1	tautomerase family protein	-
FOB71_RS16125	1856257..1856724	-	468	WP_017420818.1	hypothetical protein	-
FOB71_RS16130	1856700..1856864	-	165	Protein_1662	DUF3265 domain-containing protein	-
FOB71_RS16135	1857209..1857337	-	129	WP_080584499.1	DUF3265 domain-containing protein	-
FOB71_RS16140	1857687..1857842	-	156	WP_089529811.1	DUF3265 domain-containing protein	-
FOB71_RS16145	1857820..1858284	-	465	WP_061778618.1	hypothetical protein	-
FOB71_RS16150	1858380..1858643	-	264	WP_017420785.1	hypothetical protein	-
FOB71_RS16155	1858711..1858847	-	137	Protein_1667	DUF3265 domain-containing protein	-
FOB71_RS16160	1859382..1859624	+	243	WP_011080384.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
FOB71_RS16165	1859621..1859920	+	300	WP_017420621.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FOB71_RS16170	1860044..1861000	-	957	WP_017420620.1	hypothetical protein	-
FOB71_RS16175	1861037..1861177	-	141	WP_004401153.1	DUF3265 domain-containing protein	-
FOB71_RS16180	1861152..1861619	-	468	WP_017420618.1	NUDIX domain-containing protein	-
FOB71_RS16185	1861636..1861758	-	123	WP_072604788.1	DUF3265 domain-containing protein	-
FOB71_RS16195	1862582..1862716	-	135	WP_115173853.1	DUF3265 domain-containing protein	-
FOB71_RS16200	1863052..1863180	-	129	WP_089529830.1	DUF3265 domain-containing protein	-
FOB71_RS16205	1863538..1863648	-	111	Protein_1676	DUF3265 domain-containing protein	-
FOB71_RS16210	1864198..1864467	-	270	WP_026050329.1	Txe/YoeB family addiction module toxin	-
FOB71_RS16215	1864460..1864714	-	255	WP_017420636.1	type II toxin-antitoxin system prevent-host-death family antitoxin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1799768..1962721	162953
	-	inside	Integron	-	-	1801327..1962721	161394

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-92)

Antitoxin

• Antitoxin ParD (1-78)

Sequences

Toxin

Protein

• Length: 100 a.a.
• Molecular weight: 11669.37 Da
• Isoelectric Point: 9.9572

>T139993 WP_017420621.1 NZ_CP044069:1859621-1859920 [Vibrio vulnificus]
MRPFQLTNKAKSDLRDIALFTSRRWGREQRNIYLKQFDDSFWLLAENPDIGKACDEIRDGYRKFPQGSHVIFYRQIGSQN
IEIIRILHKSMDVNPILGA

Nucleotide

• Length: 300 bp

>T139993 NZ_CP058869:c4827776-4826859 [Klebsiella pneumoniae]
ATGGATATACAGGCGCCTTATTATCGGCAGGTTGCTCTGCTAATGCAGGTTTTACCCTATGTTGCTGTCGAACGGGAATT
TGCGCTGAAAGGTGGCACTGCCATCAATCTCTTTATCCGCGATTTCCCTCGATTATCGGTGGATATCGACCTCGCCTGGG
TGCCCCTGGAAAGCAGAGCCATCGCTTTACCTCATATACGGGATGCGCTTGCACGTATTGCCGCCAATCTGCAACAACAG
GCAGGTATGAGCGCTGTATTACAAGCTAATCGTTCAGATGAGATGCGTGTCATTGTTACTACCGATAGCGCGCAAATAAA
GATAGAGGTTTCACCGGTCGCCCGGGGAACATTATATCCACCACAGGAGCGAGAAGTGGTGGGGGCGGTAGAGGACGTTT
TTGGCTATGCCAGCCTTCCAGTGGTTTCGTTGCCTGACCTCTACGGTGGAAAATTATGCGCGGCGCTGGATCGCCAGCAT
CCCAGAGATTTTTATGACGTGAAATTACTTCTTGATGCGCAGGAGCTTGACCGTCCCATTTTCAATGGGTTTATCGTGTA
TTTACTGAGCCATAATCGGCCTCTGGCTGAAGTGCTGAATCCTCGCTGGAAAGATATTGCTGAACCTTTTTACCGTGAAT
TCAGCGGGATGACATTTGAGACGATAGCCCTGGAGGAACTGACAGCAGTCCCCAACAGGATGATTGCTGCGTTAAAATCC
TGTATCACACAACAGGATGTCGATTTTTTACTGTCATTTAAACGAGGCGAACCAGACTGGCGTTTAGCGCCGGAAATGCG
TATTCAGGATTTGCCTGCCGTGCAGTGGAAATTGCGCAATATTCATCAGATGCCAGCGATAAAACGCGCTGAGTCATTAG
ATAAACTGGAAAAGGTGCTGGCCGAGTGGCGCAGTTAG

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8953.88 Da
• Isoelectric Point: 4.2213

>AT139993 WP_011080384.1 NZ_CP044069:1859382-1859624 [Vibrio vulnificus]
MAKNTSITLGDHFDGFIANQIQSGRYGSASEVIRSALRLLETQETKMNTLRQLLVEGEESGVADYDLDSFINELDSEERK

Nucleotide

• Length: 243 bp

>AT139993 NZ_CP058869:c4828540-4827782 [Klebsiella pneumoniae]
ATGGCAACAAAATTAAACTGGCTGCTGCAAAACAGCGCTCCCGGAGATGTGATCCTTCAGTCCTGGTTAAGCCAGCATGC
CATCTCTCCCTCTCTGGCCTTTAAATATGCGCAAAGTGGCTGGTTAAAAAAAAGAGGCAACGGCGTATATGCGCGTGCGG
GACGTGAGCCGGAGTGGAACGATGCATTAGCATGTTTGCAAAATCAGCTTGCCGCTCCGGTGTATGTTGCGGGGCTCAGT
AGCTTAGTCTGGCAGGGCCGTTCACACTATCTACAGCTAAAACAAAACCAGTGCTGGCTTAGTGTGGAAAATAAAGCGCT
GCTGCCGAAATGGTTCAGGGAATTCCCGGGTGTGGAGTGGATAGTCATATCGGGGAAAAAACTGCCGGTGCTGGATGATA
GATACCGTGTAACGCTTGATATAAAAGGGAAAAAACTCATCGGCAGTGCGCCAGAACTGGCTGCTTACGAGTTGCTGAGC
GCGGTGCCGGGGACCCTCTCATTTAACCACGCTGCAGAGCTTTTCCAGGGGCTGGTTAATCTTAATCCTCGTAAAGTAGA
GTATCTTCTTTCCGTCAGCCAGTCCGTGCAGGCCAAGCGTTTGTATCTCTTCTTCGCCAGTTTTTACGAGCATGGCTGGC
TCAAACGAATCGATAGCCAAAAAATCGATCTGGGAGCGGGCAAGCGGCAAATCGTGGAAAATGGAAAGTTCAATGCTCAA
TACCAAATCACAGTGCCTGAACGCTTTCAAAAGGAATAA

Structures

Antitoxin

• AlphaFold DB: A0A0F2HR74