Detailed information of TA system TA139992

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /BrnT(toxin)
• Location: 1834874..1835372
• Replicon: chromosome
• Accession: NZ_CP044069
• Organism: Vibrio vulnificus strain FDAARGOS_663

Toxin (Protein)

• Gene name: -
• Uniprot ID: Q9KMK7
• Locus tag: FOB71_RS15915
• Protein ID: WP_000589156.1
• Coordinates: 1835106..1835372 (-)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: FOB71_RS15910
• Protein ID: WP_017420747.1
• Coordinates: 1834874..1835119 (-)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FOB71_RS15870	1830923..1831303	-	381	WP_017420745.1	hypothetical protein	-
FOB71_RS15875	1831427..1832395	+	969	WP_026050379.1	IS30-like element ISVvu6 family transposase	-
FOB71_RS15880	1832431..1832946	-	516	WP_061778615.1	GNAT family N-acetyltransferase	-
FOB71_RS15885	1832963..1833118	-	156	WP_170861654.1	DUF3265 domain-containing protein	-
FOB71_RS15890	1833081..1833524	-	444	WP_017420781.1	GNAT family N-acetyltransferase	-
FOB71_RS15895	1833527..1833688	-	162	WP_017428774.1	DUF3265 domain-containing protein	-
FOB71_RS15905	1834143..1834727	-	585	WP_017420746.1	hypothetical protein	-
FOB71_RS15910	1834874..1835119	-	246	WP_017420747.1	hypothetical protein	Antitoxin
FOB71_RS15915	1835106..1835372	-	267	WP_000589156.1	BrnT family toxin	Toxin
FOB71_RS15920	1835428..1835562	-	135	WP_081111497.1	DUF3265 domain-containing protein	-
FOB71_RS15930	1836042..1836410	-	369	WP_061778614.1	VOC family protein	-
FOB71_RS15935	1836934..1837044	-	111	WP_080573715.1	DUF3265 domain-containing protein	-
FOB71_RS15940	1837072..1837458	-	387	WP_017420617.1	hypothetical protein	-
FOB71_RS15945	1837455..1837880	-	426	WP_017420616.1	hypothetical protein	-
FOB71_RS15950	1838199..1838444	+	246	WP_026050326.1	type II toxin-antitoxin system CcdA family antitoxin	-
FOB71_RS15955	1838444..1838761	+	318	WP_026050327.1	CcdB family protein	-
FOB71_RS15960	1838761..1838880	-	120	Protein_1634	DUF3265 domain-containing protein	-
FOB71_RS15965	1838890..1839111	-	222	WP_017420735.1	VF530 family protein	-
FOB71_RS15970	1839181..1839363	-	183	WP_081111527.1	DUF3265 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1799768..1962721	162953
	-	inside	Integron	-	-	1801327..1962721	161394

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Ribonuclease toxin, BrnT, of type II toxin-antitoxin system (6-81)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10092.34 Da
• Isoelectric Point: 7.3171

>T139992 WP_000589156.1 NZ_CP044069:c1835372-1835106 [Vibrio vulnificus]
MIKFEFDENKSRSNLEKHGIDFHTAQGLWNDSDLIEIPANTSDEPRYLVVGLLNGKHWSGVITYRGTNIRIISVRRSRKA
EVSLYESA

Nucleotide

• Length: 267 bp

>T139992 NZ_CP058869:c4671666-4671382 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCTGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 9477.78 Da
• Isoelectric Point: 6.8806

>AT139992 WP_017420747.1 NZ_CP044069:c1835119-1834874 [Vibrio vulnificus]
MKAHEFDAKFESDDDDIVMNLDLSQAKRPMHKQKRVNVDFPAWMLESLDREASRIGVTRQSIIKIWLAERLESVSHHSSV
R

Nucleotide

• Length: 246 bp

>AT139992 NZ_CP058869:c4671898-4671656 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Structures

Toxin

• AlphaFold DB: A0A271VMP7