Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | parDE/ParE-YefM |
| Location | 1826845..1827390 | Replicon | chromosome |
| Accession | NZ_CP044069 | ||
| Organism | Vibrio vulnificus strain FDAARGOS_663 | ||
Toxin (Protein)
| Gene name | parE | Uniprot ID | - |
| Locus tag | FOB71_RS15845 | Protein ID | WP_017420806.1 |
| Coordinates | 1827094..1827390 (+) | Length | 99 a.a. |
Antitoxin (Protein)
| Gene name | parD | Uniprot ID | D0III5 |
| Locus tag | FOB71_RS15840 | Protein ID | WP_000557295.1 |
| Coordinates | 1826845..1827087 (+) | Length | 81 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| FOB71_RS15780 | 1822240..1822371 | - | 132 | WP_080586404.1 | DUF3265 domain-containing protein | - |
| FOB71_RS15785 | 1822383..1822772 | - | 390 | WP_017420688.1 | hypothetical protein | - |
| FOB71_RS15790 | 1822772..1822996 | - | 225 | WP_038970033.1 | membrane protein insertion efficiency factor YidD | - |
| FOB71_RS15795 | 1822999..1823214 | - | 216 | WP_017420689.1 | DUF4177 domain-containing protein | - |
| FOB71_RS15800 | 1823249..1823422 | - | 174 | WP_080586406.1 | DUF3265 domain-containing protein | - |
| FOB71_RS15810 | 1823866..1824738 | - | 873 | WP_017420690.1 | hypothetical protein | - |
| FOB71_RS15815 | 1824759..1824881 | - | 123 | Protein_1607 | DUF3265 domain-containing protein | - |
| FOB71_RS15820 | 1825363..1825650 | - | 288 | WP_017420802.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| FOB71_RS15825 | 1825647..1825928 | - | 282 | WP_017420803.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| FOB71_RS15830 | 1825885..1826130 | - | 246 | WP_080586405.1 | DUF3265 domain-containing protein | - |
| FOB71_RS15835 | 1826137..1826544 | - | 408 | WP_017420805.1 | hypothetical protein | - |
| FOB71_RS15840 | 1826845..1827087 | + | 243 | WP_000557295.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| FOB71_RS15845 | 1827094..1827390 | + | 297 | WP_017420806.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| FOB71_RS15850 | 1827587..1828162 | - | 576 | WP_017420807.1 | hypothetical protein | - |
| FOB71_RS15855 | 1828196..1828318 | - | 123 | WP_017428757.1 | DUF3265 domain-containing protein | - |
| FOB71_RS15860 | 1828661..1828789 | - | 129 | WP_080589837.1 | DUF3265 domain-containing protein | - |
| FOB71_RS15865 | 1829394..1830926 | + | 1533 | Protein_1617 | IS3 family transposase | - |
| FOB71_RS15870 | 1830923..1831303 | - | 381 | WP_017420745.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 1799768..1962721 | 162953 | |
| - | inside | Integron | - | - | 1801327..1962721 | 161394 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 99 a.a. Molecular weight: 11306.95 Da Isoelectric Point: 9.6425
>T139991 WP_017420806.1 NZ_CP044069:1827094-1827390 [Vibrio vulnificus]
MQKNKYKLSKLAQTHLQKIRNYTVNNFSEMQWRSYKDTLLTGFQMLADNPAVGRSCDEIYPSGFYFPVGKHTAYFTKEDG
FILVVAVLGQSQLPQNHL
MQKNKYKLSKLAQTHLQKIRNYTVNNFSEMQWRSYKDTLLTGFQMLADNPAVGRSCDEIYPSGFYFPVGKHTAYFTKEDG
FILVVAVLGQSQLPQNHL
Download Length: 297 bp
>T139991 NZ_CP058869:c4550745-4550212 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGCGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAGGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGCGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAGGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA
Antitoxin
Download Length: 81 a.a. Molecular weight: 9002.17 Da Isoelectric Point: 4.7914
>AT139991 WP_000557295.1 NZ_CP044069:1826845-1827087 [Vibrio vulnificus]
MHTLTANDAKRNFGELLLSAQREPVKISKNSKDAVVVMSIKDYEELEAMKTDYLRHCFESAKQDLAQGNVVDGEDFLNAL
MHTLTANDAKRNFGELLLSAQREPVKISKNSKDAVVVMSIKDYEELEAMKTDYLRHCFESAKQDLAQGNVVDGEDFLNAL
Download Length: 243 bp
>AT139991 NZ_CP058869:c4551022-4550756 [Klebsiella pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|