Detailed information of TA system TA139989

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-RHH
• Location: 1811327..1811865
• Replicon: chromosome
• Accession: NZ_CP044069
• Organism: Vibrio vulnificus strain FDAARGOS_663

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: FOB71_RS15700
• Protein ID: WP_017420621.1
• Coordinates: 1811566..1811865 (+)
• Length: 100 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A0F2HR74
• Locus tag: FOB71_RS15695
• Protein ID: WP_011080384.1
• Coordinates: 1811327..1811569 (+)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FOB71_RS15630	1806370..1806786	-	417	WP_026060790.1	VOC family protein	-
FOB71_RS15635	1806813..1806941	-	129	WP_080586393.1	DUF3265 domain-containing protein	-
FOB71_RS15640	1806895..1807818	-	924	WP_017420366.1	FRG domain-containing protein	-
FOB71_RS15645	1807797..1807904	-	108	WP_100222774.1	iron transporter	-
FOB71_RS15650	1807961..1808495	-	535	Protein_1578	GNAT family N-acetyltransferase	-
FOB71_RS15655	1808455..1808646	-	192	WP_080586391.1	DUF3265 domain-containing protein	-
FOB71_RS15660	1808980..1809108	-	129	WP_115173855.1	DUF3265 domain-containing protein	-
FOB71_RS15665	1809112..1809759	-	648	WP_017420776.1	DUF805 domain-containing protein	-
FOB71_RS15670	1809770..1809931	-	162	WP_081111522.1	DUF3265 domain-containing protein	-
FOB71_RS15675	1810246..1810386	-	141	WP_089529831.1	DUF3265 domain-containing protein	-
FOB71_RS15680	1810401..1810634	-	234	WP_043037921.1	hypothetical protein	-
FOB71_RS15685	1810672..1810794	-	123	WP_017420820.1	DUF3265 domain-containing protein	-
FOB71_RS15690	1810816..1811034	-	219	WP_005527676.1	hypothetical protein	-
FOB71_RS15695	1811327..1811569	+	243	WP_011080384.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
FOB71_RS15700	1811566..1811865	+	300	WP_017420621.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FOB71_RS15705	1811826..1812017	-	192	WP_081111512.1	DUF3265 domain-containing protein	-
FOB71_RS15710	1812005..1812223	-	219	WP_005527676.1	hypothetical protein	-
FOB71_RS15715	1812711..1812932	-	222	WP_017420770.1	DUF3265 domain-containing protein	-
FOB71_RS15720	1812896..1813810	-	915	WP_017420771.1	alpha/beta hydrolase	-
FOB71_RS15725	1813879..1814024	-	146	Protein_1593	DUF3265 domain-containing protein	-
FOB71_RS15730	1814355..1814483	-	129	WP_080722193.1	DUF3265 domain-containing protein	-
FOB71_RS15735	1815088..1816620	+	1533	Protein_1595	IS3 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1799768..1962721	162953
	-	flank	IS/Tn	-	-	1816069..1816620	551
	-	inside	Integron	-	-	1801327..1962721	161394

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-92)

Antitoxin

• Antitoxin ParD (1-78)

Sequences

Toxin

Protein

• Length: 100 a.a.
• Molecular weight: 11669.37 Da
• Isoelectric Point: 9.9572

>T139989 WP_017420621.1 NZ_CP044069:1811566-1811865 [Vibrio vulnificus]
MRPFQLTNKAKSDLRDIALFTSRRWGREQRNIYLKQFDDSFWLLAENPDIGKACDEIRDGYRKFPQGSHVIFYRQIGSQN
IEIIRILHKSMDVNPILGA

Nucleotide

• Length: 300 bp

>T139989 NZ_CP058869:c2651224-2649902 [Klebsiella pneumoniae]
ATGGCGACGCTTACCACCTGGATGAACAATGTGCGCGTGGGAACCTTAACCCGCCAGGCTAACGGGGCGCACAGTTTTCG
CTATGACGAAGAGTGGCTGCGCAGCCCGCGCGCCAGACCGCTCTCCCTCTCACTGCCGCTGCAGTATGGCAATATCACTG
CCGACGCGGTGTATCACTATTTTGATAACCTGCTGCCCGATAGCCCGCAGGTCCGCGACCGGATCGTCAGGCGCTATCAG
GCGCACTCGAAGCAGCCGTTCGATCTGCTGGCCGAAGTCGGGCGGGATAGCGTAGGGGCGGTGACCCTCCTGCCGCCGGG
GGAAGAGGCGCACCTGGAAGGATTACGCTGGCAGACGCTGGACGAGGCGCAGCTCACCGCTTTGCTGACCGCTTACCAGT
CGGATATCCCCCTCGGGATGATTACCAGCCAGGACGATTTCCGTATCTCGGTGGCCGGCGCCCAGGAGAAAACGGCGCTG
CTGCGGATGGGCGAGCAGTGGTGTATTCCGCAGGGCGCCACGCCGACCACGCATATCATTAAGTTGCCCATCGGCGAGAT
AAAGCAGCCCAATGCGACGCTGGATCTGCGCGAAAGCGTGGATAATGAGTATCTGTGCCTGGCGCTGGCCAGAGAACTGG
GCCTGGCGGTGCCGGAAGCGGAGATCATCACCACCCCGCGGATCCGCGCCCTGGCGGTAACCCGCTTCGACCGGCGCTGG
GCGCAGGAGGGACGGGTGCTGCTGCGTCTGCCGCAGGAGGATCTGTGTCAGGCTTTTGGTCTTCCTTCAGCGATGAAATA
TGAGTCTGACGGCGGGCCGGGTATCGCCGCGATCATGACCTTTCTGCTGGGCTCGAGTGAAGCGCTGAAAGATCGCTATG
ACTTTATGAAGTTCATGGTCTTCCAGTGGCTGACGGGGGCGACGGACGGTCACGCAAAAAACTTCTCAATTTACCTGTTG
CCCGGCGGCAGCTACCGCTTAACACCGTTCTACGACATTATTTCGGCGTTTCCGGTGCTGGGCGGCACGGGACTGCATCT
GCGCGATCTGAAGCTGTCGATGGGGCTCAATGCCACAAAAGGGCGTAAAACAGAGATTAACGCCATCTATCCGCGTCATT
TTCTGGCGACGGCCAAAGCGGTGAACTTTCCCCGGGAGCAGATGCTGGCGATCCTCCAGGAGTTTGCCGGGCATGTGCCG
CAGGCAATCGAAAGCGCTCGCCGGACGCTGCCGGCGGACTTTTCCAGCCACGTCTGGCAGGCTATTACAGAGAACATGCT
GAAGCTGCACGCCCGCCTGCAGCAAGGACTGCAGGCGCTATAG

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8953.88 Da
• Isoelectric Point: 4.2213

>AT139989 WP_011080384.1 NZ_CP044069:1811327-1811569 [Vibrio vulnificus]
MAKNTSITLGDHFDGFIANQIQSGRYGSASEVIRSALRLLETQETKMNTLRQLLVEGEESGVADYDLDSFINELDSEERK

Nucleotide

• Length: 243 bp

>AT139989 NZ_CP058869:c2651490-2651224 [Klebsiella pneumoniae]
ATGAATTCCCCGCAGATATACAGTCCCGTGCAGCTGGCCAATTACCTGAAGCTGCTGCGCCAGCAGAACCACTGGACCCA
GGATGCGCTGGCCAGGCGGATCGGCATTAAGCAGGCCACGCTGTCCAATTTTGAAAATCACCCCGACAAAACCACCTTAA
CCACGCTGTTTAAGATCCTCCAGTCGCTGGGGGTGGTGATGATGCTGAACGCCAAAGCTGCTGAGACGGCGCCGGCTCCC
GATAACAACACGGACCTTGACTGGTAA

Structures

Antitoxin

• AlphaFold DB: A0A0F2HR74