Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-YafN |
| Location | 1802770..1803298 | Replicon | chromosome |
| Accession | NZ_CP044069 | ||
| Organism | Vibrio vulnificus strain FDAARGOS_663 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | K5TRR0 |
| Locus tag | FOB71_RS15565 | Protein ID | WP_005377002.1 |
| Coordinates | 1803008..1803298 (+) | Length | 97 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | A0A347UR02 |
| Locus tag | FOB71_RS15560 | Protein ID | WP_005377003.1 |
| Coordinates | 1802770..1803018 (+) | Length | 83 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| FOB71_RS15540 | 1799768..1801300 | - | 1533 | Protein_1559 | IS3 family transposase | - |
| FOB71_RS15545 | 1801327..1802088 | - | 762 | WP_089529815.1 | TIM44-like domain-containing protein | - |
| FOB71_RS15550 | 1802115..1802237 | - | 123 | WP_081111495.1 | DUF3265 domain-containing protein | - |
| FOB71_RS15555 | 1802603..1802713 | - | 111 | WP_072599523.1 | DUF3265 domain-containing protein | - |
| FOB71_RS15560 | 1802770..1803018 | + | 249 | WP_005377003.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| FOB71_RS15565 | 1803008..1803298 | + | 291 | WP_005377002.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| FOB71_RS15570 | 1803438..1803851 | - | 414 | WP_017420361.1 | VOC family protein | - |
| FOB71_RS15580 | 1803925..1804017 | - | 93 | WP_017420362.1 | DUF3265 domain-containing protein | - |
| FOB71_RS15585 | 1804053..1804355 | - | 303 | WP_017420363.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| FOB71_RS15590 | 1804343..1804600 | - | 258 | WP_017420364.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| FOB71_RS15595 | 1804671..1804742 | - | 72 | WP_072599534.1 | hypothetical protein | - |
| FOB71_RS15600 | 1804844..1805263 | + | 420 | WP_017420365.1 | BLUF domain-containing protein | - |
| FOB71_RS15610 | 1805399..1805578 | - | 180 | WP_080586392.1 | hypothetical protein | - |
| FOB71_RS15615 | 1805775..1805897 | - | 123 | WP_080586394.1 | DUF3265 domain-containing protein | - |
| FOB71_RS15625 | 1806263..1806373 | - | 111 | WP_017420369.1 | DUF3265 domain-containing protein | - |
| FOB71_RS15630 | 1806370..1806786 | - | 417 | WP_026060790.1 | VOC family protein | - |
| FOB71_RS15635 | 1806813..1806941 | - | 129 | WP_080586393.1 | DUF3265 domain-containing protein | - |
| FOB71_RS15640 | 1806895..1807818 | - | 924 | WP_017420366.1 | FRG domain-containing protein | - |
| FOB71_RS15645 | 1807797..1807904 | - | 108 | WP_100222774.1 | iron transporter | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 1799768..1962721 | 162953 | |
| - | inside | Integron | - | - | 1801327..1962721 | 161394 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 97 a.a. Molecular weight: 11261.25 Da Isoelectric Point: 10.5932
>T139987 WP_005377002.1 NZ_CP044069:1803008-1803298 [Vibrio vulnificus]
MTYKLDFKKSALKEWKKLGSTLQQQFKKKLIERLDNPHVPASKLSGADNMYKIKLRQSGYRLVYKVEDDVIIVTVLAVGK
RERSDVYRKAMKRLDD
MTYKLDFKKSALKEWKKLGSTLQQQFKKKLIERLDNPHVPASKLSGADNMYKIKLRQSGYRLVYKVEDDVIIVTVLAVGK
RERSDVYRKAMKRLDD
Download Length: 291 bp
>T139987 NZ_CP058869:835171-835581 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA
Antitoxin
Download Length: 83 a.a. Molecular weight: 9079.37 Da Isoelectric Point: 3.9610
>AT139987 WP_005377003.1 NZ_CP044069:1802770-1803018 [Vibrio vulnificus]
MTTRILADVAASITELKANPMKVATSAYGEPVAVLNRNEPAFYCVPAEAYEMMMDRLEDLELLAIAKERESEESISVNID
DL
MTTRILADVAASITELKANPMKVATSAYGEPVAVLNRNEPAFYCVPAEAYEMMMDRLEDLELLAIAKERESEESISVNID
DL
Download Length: 249 bp
>AT139987 NZ_CP058869:834924-835190 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A347UR03 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A347UR02 |