Detailed information of TA system TA139986

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-couple_hipB
• Location: 796719..798547
• Replicon: chromosome
• Accession: NZ_CP044069
• Organism: Vibrio vulnificus strain FDAARGOS_663

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: FOB71_RS11050
• Protein ID: WP_026050323.1
• Coordinates: 797186..798547 (-)
• Length: 454 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: FOB71_RS11045
• Protein ID: WP_017420006.1
• Coordinates: 796719..797201 (-)
• Length: 161 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FOB71_RS11025	792732..793286	+	555	WP_011078504.1	hypothetical protein	-
FOB71_RS11030	793288..794043	+	756	WP_017420003.1	NRDE family protein	-
FOB71_RS11035	794058..794495	+	438	WP_017420004.1	YHS domain-containing protein	-
FOB71_RS11040	794538..796280	+	1743	WP_017420005.1	lysophospholipid acyltransferase family protein	-
FOB71_RS11045	796719..797201	-	483	WP_017420006.1	helix-turn-helix domain-containing protein	Antitoxin
FOB71_RS11050	797186..798547	-	1362	WP_026050323.1	type II toxin-antitoxin system HipA family toxin	Toxin
FOB71_RS11060	799443..799928	-	486	WP_017420008.1	SsrA-binding protein SmpB	-
FOB71_RS11065	800045..800476	+	432	WP_026050324.1	ubiquinone-binding protein	-
FOB71_RS11070	800473..800826	+	354	WP_017420009.1	RnfH family protein	-
FOB71_RS11075	800923..801282	-	360	WP_017420010.1	outer membrane protein assembly factor BamE	-
FOB71_RS11080	801460..803124	-	1665	WP_017420011.1	DNA repair protein RecN	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (166-385)

Antitoxin

• Cro/C1-type helix-turn-helix domain (85-140)

Sequences

Toxin

Protein

• Length: 454 a.a.
• Molecular weight: 51419.37 Da
• Isoelectric Point: 5.0596

>T139986 WP_026050323.1 NZ_CP044069:c798547-797186 [Vibrio vulnificus]
MEELTVQAFIRGEWIDIGIISFPKSSQHNFRVTELNYLSDYALEHHDKDDFHAVSLNHPISFFFDDMGKPGWLKFLDDIM
PSGASRRYWIKHLDIEDLSSDEQDYVLLKFGTMSPIGNLRIKDSLPERYEVADNLYFSVDDVKNRAGDFLDYAQQRGAAA
GGATGAGGEAPKLILRCGFDHGSGSEKIWIDPYQDDNSNHDLHYLVKYPRGSRSTIDCNILRAEFYFYHELTEMGVETIA
TEGMRLEEGLNYPSLWLPRFDVQIINQQIKRFGMESVYSILKKGAGVTLDHESTIRTLIEKITESNMVKHQGYRFDIQAF
VIEWVKRDLLNILFGNSDNHGRNTSFLKGDGVIKLAPVYDFAPMKADPEGIPRTTKWKAPLEVGGTYDFVGIADTLSDLV
PKEVLLQELEVTASKCIDLKQRLALRGVPEQILEMPAVGLNHISEKLTKWGLL

Nucleotide

• Length: 1362 bp

>T139986 NZ_CP058869:681622-681963 [Klebsiella pneumoniae]
ATGAAAACTCTACCTGCTATAATTTCGCGGGCGGCGAAGCCCTGTCTGTCGCCCGTTGCAGTCTGGCAAATGCTACTTAC
ACGCCTGCTGGAAAAACACTATGGTCTGACCCTGAACGATACGCCGTTCTGTGATGAAACCGTTATACAGGAACATATCG
ATGCCGGTATTACGCTGGCTGATGCCGTTAATTTTCTGGTGGAAAAATACGGACTGGTTCGTATCGACAGGAATGGATTT
GTCTGGCAGGAACAATCACCTTATCTTCGGGCCGTTGATATTCTGCGAGCGCGGCAGGCAACTGGCTTATTGCGACAAAG
CCGTAACAACGCAATACGTTGA

Antitoxin

Protein

• Length: 161 a.a.
• Molecular weight: 17505.02 Da
• Isoelectric Point: 10.8446

>AT139986 WP_017420006.1 NZ_CP044069:c797201-796719 [Vibrio vulnificus]
MGATMNKPSNKESVQDTVARLRANRNQHQPKAGTDATHSTKERSQLNTPTRSKTSKNAKAVSAAERKTEANKIIKHLLLG
ELTQGQALKSLRINILGLKQDVFARLVDVSRKTLSDIENDRGSYNTEILNKVFKPFGLKVGMLPSSPDVLKSLLIDGEAG

Nucleotide

• Length: 483 bp

>AT139986 NZ_CP058869:681284-681601 [Klebsiella pneumoniae]
ATGAGCAACATTACATGGGGCCTGCAGCGGGATACCACGCCGCGTCTGGGAGCCCGTCTGGTACAGGAGGGGAACCAACT
GCATTATCTGGCTGACCGGGCCAGTATGACCGGTAAATTCAGTGACGCCGAATGCCGGAAGCTGGATGAAACATTCCCGC
ACTTTATCAGCCAGATGGAATCGATGCTGATCACTGGTGAAATGAATCCTCGCCATGCCCACTGTGTCACCCTGTACCAC
AACGGTTTTACCTGCGAAGCCGATACCCTTGGCAGTTGCGGCTACGTATACATCGCCGTTTACCCCATCCAACGATAA