139985

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 1440433..1440992 Replicon chromosome
Accession NZ_CP044068
Organism Vibrio vulnificus strain FDAARGOS_663

Toxin (Protein)


Gene name relE Uniprot ID A0A2S3R8G0
Locus tag FOB71_RS06140 Protein ID WP_017420107.1
Coordinates 1440433..1440711 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A3Q0L0M2
Locus tag FOB71_RS06145 Protein ID WP_011082348.1
Coordinates 1440708..1440992 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOB71_RS06110 1436016..1436744 + 729 WP_017420112.1 MipA/OmpV family protein -
FOB71_RS06115 1436994..1437458 + 465 WP_017420111.1 hypothetical protein -
FOB71_RS06120 1437495..1438118 + 624 WP_017420110.1 hypothetical protein -
FOB71_RS06125 1438235..1438750 + 516 WP_017420109.1 lipocalin family protein -
FOB71_RS06130 1439872..1440297 + 426 WP_017420108.1 hypothetical protein -
FOB71_RS06135 1440294..1440404 + 111 WP_080586425.1 DUF3265 domain-containing protein -
FOB71_RS06140 1440433..1440711 - 279 WP_017420107.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
FOB71_RS06145 1440708..1440992 - 285 WP_011082348.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
FOB71_RS06150 1441210..1441818 + 609 WP_017420106.1 hypothetical protein -
FOB71_RS06155 1441953..1442486 + 534 WP_017420105.1 hypothetical protein -
FOB71_RS06160 1442672..1442935 + 264 WP_011082346.1 hypothetical protein -
FOB71_RS06165 1443012..1443512 + 501 WP_017420104.1 hypothetical protein -
FOB71_RS06170 1443592..1444623 - 1032 WP_017420103.1 L-threonine 3-dehydrogenase -
FOB71_RS06175 1444738..1445931 - 1194 WP_011082341.1 glycine C-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-45)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10848.55 Da        Isoelectric Point: 4.2397

>T139985 WP_017420107.1 NZ_CP044068:c1440711-1440433 [Vibrio vulnificus]
MILWEEESLNDREKIFEFLYDFNPDAAEKTDNLIEAKVENLLEQPLMGVQRDGILGRLLIIPEISMVISYWVEGDIIRVM
RVLHQKQKFPTD

Download         Length: 279 bp

>T139985 NZ_CP058869:323149-323517 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCGGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGCGGATGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 11083.43 Da        Isoelectric Point: 9.2167

>AT139985 WP_011082348.1 NZ_CP044068:c1440992-1440708 [Vibrio vulnificus]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKTLSHDAWLTEQVNLAFEKFDSGKSVFIEHQTAKSR
MEERKARIRNRGKQ

Download         Length: 285 bp

>AT139985 NZ_CP058869:322931-323152 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2S3R8G0

Antitoxin

Source ID Structure
AlphaFold DB A0A3Q0L0M2

References