Detailed information of TA system TA139984

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): sanaTA/AbiEii-DUF6088
• Location: 1037022..1038369
• Replicon: chromosome
• Accession: NZ_CP044068
• Organism: Vibrio vulnificus strain FDAARGOS_663

Toxin (Protein)

• Gene name: sanaT
• Uniprot ID: -
• Locus tag: FOB71_RS04435
• Protein ID: WP_017422918.1
• Coordinates: 1037022..1037963 (-)
• Length: 314 a.a.

Antitoxin (Protein)

• Gene name: sanaA
• Uniprot ID: A0A854GL31
• Locus tag: FOB71_RS04440
• Protein ID: WP_017422919.1
• Coordinates: 1037965..1038369 (-)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FOB71_RS04420	1034737..1035303	-	567	WP_017422914.1	hypothetical protein	-
FOB71_RS04435	1037022..1037963	-	942	WP_017422918.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
FOB71_RS04440	1037965..1038369	-	405	WP_017422919.1	hypothetical protein	Antitoxin
FOB71_RS04445	1038703..1040463	+	1761	WP_017422920.1	ABC transporter ATP-binding protein/permease	-
FOB71_RS04450	1040516..1041280	-	765	WP_017422921.1	nucleotidyltransferase domain-containing protein	-
FOB71_RS04455	1041599..1041793	+	195	WP_127891366.1	hypothetical protein	-
FOB71_RS04460	1041780..1042526	-	747	WP_026050861.1	carbon-nitrogen hydrolase family protein	-
FOB71_RS04465	1042716..1043174	-	459	WP_011081157.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (33-300)

Antitoxin

• Protein of unknown function DUF6088 (7-130)

Sequences

Toxin

Protein

• Length: 314 a.a.
• Molecular weight: 36018.40 Da
• Isoelectric Point: 5.3175

>T139984 WP_017422918.1 NZ_CP044068:c1037963-1037022 [Vibrio vulnificus]
MNTLKQKFLEVSDALELGNPAIIEKDFWVVALLAELAKVSPEYHQMVFSGGTALAKSNVKILRMSEDVDIKLIPNQAFDE
LSRAKKKAVRKAWVNEIEQAITHSERFTVETRAVRDEYRYVEFELRYPQQFSQAPCLRPIIKLELIETIPLLDVESRSIQ
SLVAELYQQPHEVSSFDCVSVYATLVEKIISMLRRTMSVKRNTERTDDVALVRHIYDVHCITKLSTTELNSIDGLFKAVL
EEDIARFGNQNAEFVANPKQELQLGLKELEENPIFRQRFQDFVTPMVFNTEPHDFDTCFASFKRIAASLIEKI

Nucleotide

• Length: 942 bp

>T139984 NZ_CP058868:c58043-57627 [Klebsiella pneumoniae]
ATGAAGAAAACCTGGATGCTCGACACCAACATCTGCTCGTTCATCATGCGCGAGCAGCCGGCAGCGGTGCTGAAGCGCCT
GGAGCAGGCGGTGCTGCGCGGTGATCGCATTGTGGTCTCGGCCGTGACGTATGCCGAGATGCGCTTCGGCGCCACCGGCC
CGAAGGCCTCGCCGCGCCATATTCAGCTGGTCGACGCGTTCTGCGCGCGCCTCGATGCCGTCCTGCCCTGGGACCGCGCC
GCGGTGGACGCCACGACGGACATCCGGGTGGCGCTGCGCCTAGCCGGGACGCCGATCGGCCCGAATGACACGGCCATTGC
CGGGCACGCCATCGCGGCGGGCGCCATCCTGGTGACGAACAATGTGAGAGAGTTTGCGCGGGTCCCGGGCCTGGTGCTGG
AAGACTGGGTGAAATAA

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 15115.43 Da
• Isoelectric Point: 10.6258

>AT139984 WP_017422919.1 NZ_CP044068:c1038369-1037965 [Vibrio vulnificus]
MTAVDRICQKIKRSRRYVFERKDFDGFASYDQIGRALRQLVQQGELMKLGYGLYTKARINSLTGKPMPTNPGGTDALVRE
ILKMKGVDFEMDSLSQQSLSGASTQIPSSVHYSWNPKQFNRKLVVGSRVLNLPS

Nucleotide

• Length: 405 bp

>AT139984 NZ_CP058868:c58270-58040 [Klebsiella pneumoniae]
ATGCGCACAGTTTCGATATTTAAAAACGGCAATAACCGCGCCATCCGTCTGCCCCGGGACCTGGATTTTGATGGCGTCAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGCTGG
ACAGGGCCGATCCGGACTTTATGGCGGAGCGTGAGGATGTGGTCAGCGATGAAGGACGCTTTGAGCCATGA

Structures

Antitoxin

• AlphaFold DB: A0A854GL31