Detailed information of TA system TA139983

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicB(antitoxin)
• Location: 526088..526751
• Replicon: chromosome
• Accession: NZ_CP044065
• Organism: Cupriavidus pauculus strain FDAARGOS_664

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: FOB72_RS02500
• Protein ID: WP_150371085.1
• Coordinates: 526088..526273 (+)
• Length: 62 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: FOB72_RS02505
• Protein ID: WP_150371086.1
• Coordinates: 526332..526751 (+)
• Length: 140 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FOB72_RS02485	521797..523326	+	1530	WP_150371082.1	PLP-dependent aminotransferase family protein	-
FOB72_RS02490	523429..525330	+	1902	WP_150371083.1	molecular chaperone HtpG	-
FOB72_RS02495	525363..525863	+	501	WP_150371084.1	DNA-deoxyinosine glycosylase	-
FOB72_RS02500	526088..526273	+	186	WP_150371085.1	type II toxin-antitoxin system HicA family toxin	Toxin
FOB72_RS02505	526332..526751	+	420	WP_150371086.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
FOB72_RS02510	526759..527994	-	1236	WP_191002178.1	MFS transporter	-
FOB72_RS02515	528044..528325	-	282	WP_150371088.1	hypothetical protein	-
FOB72_RS02520	528596..529087	-	492	WP_150371089.1	hypothetical protein	-
FOB72_RS02525	529293..530054	+	762	WP_150371090.1	tetratricopeptide repeat protein	-
FOB72_RS02530	530091..530987	+	897	WP_191002179.1	spermidine synthase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (3-60)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (4-119)

Sequences

Toxin

Protein

• Length: 62 a.a.
• Molecular weight: 6916.97 Da
• Isoelectric Point: 10.9526

>T139983 WP_150371085.1 NZ_CP044065:526088-526273 [Cupriavidus pauculus]
MKYSEFRRWLARQGATFEKHKAGSSHYRVTLNGKTTIFPDHGAREIGTGLVEAIKKQLGIK

Nucleotide

• Length: 186 bp

>T139983 NZ_CP058867:36312-36782 [Klebsiella pneumoniae]
GTGATCCTCTACAGGCTGACGAAAACAAAGTATCTTTCTACGGCCTGGACCGGATATGGTGCGAAAGAGGCTGGTGGGCG
CTGGAATAGCGTGGGGGTGTCAATGGTATATGTCTCCGAAACGGCATCACTAACGATGCTGGAGACGCTGGTACACCTGC
ATGCGGCACAGATAATGGACTCTTTCACTCTACTGAGTATCGATGTGCCTGATGAACTGATCCAAAGCGCAAACATGGAT
GAATTACCGGGCAACTGGGCTGATGAGGATGCGCCTCAGGAACTGGCTGATTACGGAGATGCCTGGTCATTTACCAGGAG
CTCGGTTGCACTGCGTGTTCCCTCAGCCTTATCGCCGGTAGAGTTCAATTATCTGTTAAATCCTGAGCACCCTGAGTTTT
ACGGGATTGTGCAGAAGGCTCAACAGATACCGTTCCGGTTTGATAGTCGTCTTAAACCTGACAGGAAGTGA

Antitoxin

Protein

• Length: 140 a.a.
• Molecular weight: 15386.86 Da
• Isoelectric Point: 6.4791

>AT139983 WP_150371086.1 NZ_CP044065:526332-526751 [Cupriavidus pauculus]
MFAYPVNLTPDDNGTLLVTFKDVPEAITAGESEDDALTQALDALEAAFEIYFAEKRPIPMPSKPKRGQRVVQLPVLTATK
VLLANEMLAQKVRKSDLARRMGINQVQVDRMLKMNHATRVESLETALGTLGRHLEVSLV

Nucleotide

• Length: 420 bp

>AT139983 NZ_CP058867:35872-36315 [Klebsiella pneumoniae]
ATGAAAACATTTAGTTTGTCCTCAACTCCAGCCAGACCACAGCGCCTCTGGCAGGTTGCCGGGTTAAATAATGCTGATGG
CGTAGCGCTTCTGGGCCAAATCAATGAAGGCCTGGACGGGAAGGTGGCGAACCGGATCACTGACTGGGCCAGAATAACCC
AGAATGACCTGAGAAAAATGTCCGGTATCCCGTCGACCACTTTTAGCCGCAGTGTGAAGGCACGTTTTAACCCGGAACAA
AGTGAACGTCTGGTACGGATTATCCGCGTCATTGATCGGGCGGTAGATTTGTTTGAAGGCGACAAGGAAGCCGCACAGAA
GTGGTTGAACGAACCTAACCGGGCATTGAGCTGGAAAGTGCCAGCAGACCTGATGGCATCCGAGACGGGAGCCTATGAGG
TCATTAAGCTGATTACGCGTCTGGAGCATGGGGTGTACTCGTGA